“…In other words, there is an apparent lack of data from human NMDA receptors. Relatively few studies have described functional properties of heterologously expressed human NMDA receptors (Bednar et al, 2004; Claiborne et al, 2003; Curtis et al, 2003; Daggett et al, 1998; Feuerbach et al, 2010; Grimwood et al, 1996a; Grimwood et al, 1996b; Hess et al, 1996; Hess et al, 1998; Le Bourdelles et al, 1994; Priestley et al, 1996; Priestley et al, 1995; Steinmetz et al, 2002; Steinmetz et al, 2004; Usala et al, 2003; Varney et al, 1996; Wafford et al, 1995). Although the amino acid sequence is highly conserved between rat and human subunits, some variation exist that may nonetheless confer significant pharmacological and functional differences.…”