Comparative pharmacokinetics of doxycycline in crayfish (Procambarus clarkii) following oral, intramuscular, and intrasinus administrations

Xu, Ning; Sun, Weiyu; Gong, Lve; Liu, Yongtao; Dong, Jing; Yang, Yibin; Zhou, Shun; Ai, Xiaohui

doi:10.1016/j.aquaculture.2022.737941

Cited by 3 publications

(2 citation statements)

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“…In this study, we investigated the PK and PD properties (MIC value) of DO administered by IV, IM and OR administration routes in rainbow trout. The PK/PD integration of DO has been conducted in fish (Xu et al., 2022). However, to our knowledge, this is the first study to determine the PK and PD characteristics of DO in rainbow trout ( O. mykiss ) after OR, IM and IV administrations.…”

Section: Discussionmentioning

confidence: 99%

“…There are a few studies on the PKs of DO in aquatic animals, including grass crap (Xu et al., 2020b), crayfish (Xu et al., 2022), catfish (Xu et al., 2021) and tilapia (Yang et al., 2014), and other animal species, such as goat. In these studies, it was determined that DO has advantages such as a wide volume of distribution and long elimination half‐life in fish.…”

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetic behaviour and pharmacokinetic–pharmacodynamic integration of doxycycline in rainbow trout (Oncorhynchus mykiss) after intravascular, intramuscular and oral administrations

Altan,

Corum,

Durna Corum

et al. 2024

Veterinary Medicine & Sci

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ObjectiveDoxycycline (DO) has been used in fish for a long time, but there are some factors that have not yet been clarified regarding its pharmacokinetic (PK) and pharmacodynamic (PD) properties. Therefore, the aim of this study was to investigate the PK and PK/PD targets of DO after 20 mg/kg intravascular (IV), intramuscular (IM) and oral (OR) gavage administration in rainbow trout (Oncorhynchus mykiss).MethodsPlasma samples were collected at specific time points and subsequently analysed by HPLC‐ultraviolet. The PK/PD indices were calculated based on the MIC90 (Aeromonas hydrophila and Aeromonas sobria) values obtained for the respective bacteria and the PK parameters obtained for DO following both IM and OR administration.ResultsAfter IV administration, the elimination half‐life (t1/2ʎz), area under the concentration vs. time curve (AUC), apparent volume of distribution at steady‐state and total body clearance of DO were 34.81 h, 723.82 h µg/mL, 1.24 L/kg and 0.03 L/kg/h, respectively. The t1/2λz of the DO was found to be 37.39 and 39.78 h after IM, and OR administration, respectively. The bioavailability was calculated 57.02% and 32.29%, respectively, after IM and OR administration. The MIC90 of DO against A. hydrophila and A. sobria was 4 µg/mL. The PK/PD integration showed that DO (20 mg/kg dose) for A. hydrophila and A. sobria with MIC90 ≤4 µg/mL achieved target AUC/MIC value after IM administration.ConclusionsThese results suggest that when rainbow trout was treated with 20 mg/kg IV and IM administered DO, therapeutically effective concentrations were reached in the control of infections caused by A. hydrophila and A. sobria.

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Section: Discussionmentioning

confidence: 99%