Comparative pharmacokinetics of coumarin anticoagulants XLVI: Effect of treatment with phenobarbital on pharmacokinetics of (S)-(−)-warfarin in rats

The effect of Fluosol-DA and Hespan haemodilution on S-warfarin elimination in the rat

“…Separating the blood sample collection into three periods would allow any isoenzymeenhancement to beclearly identified. S-Warfarin tf reportedly ranges from 10 to 48 h with a mean of 22.4 h in the rat (Yacobi & Levy 1977;Yacobi et al 1980). The control t)data in Table 1 wereconsistent with these reports.…”

“…It was not possible to measure Vd in this study because ofits design, but the result was not unexpected. An increased S-warfarin free fraction has been shown to increase the S-warfarin Vd (Yacobi et al 1980). An increased free fraction could result from the decreased serum protein concentration following haemodilution, or a displacement of S-warfarin from serum protein binding sites by either Fluosol or Hespan or an endogenous substance released secondary to haemodilution.…”