Comparative pharmacokinetics of baicalin in normal and the type 2 diabetic rats after oral administration of the Radix scutellariae extract

Simultaneous determination of five isoflavones in rat plasma by LC‐MS/MS: Comparative pharmacokinetic characteristics of Puerariae lobatae radix in normal and type 2 diabetic rats

“…Daidzein and genistein are isoflavone aglycones, which can be produced by the metabolic transformation of puerarin, daidzin, and other isoflavone glycosides in PLR extract by enzymes or gut microbiota before they are absorbed into circulation. It has been reported that the function of many transporters and enzymes related to intestinal transportation and metabolism of drugs could be affected in pathological state [29][30][31]. Additionally, several studies have confirmed that the composition of the gut microbiota is changed in high-fat diet and low dose STZ-induced type 2 diabetic rats [32,33].…”

Comparative pharmacokinetic and tissue distribution profiles of four major bioactive components in normal and hepatic fibrosis rats after oral administration of Fuzheng Huayu recipe

“…It has been reported that pharmacokinetics and biodistribution may be influenced by pathological status [8], such as type 2 diabetes [9] and non-alcoholic fatty liver disease [10]. Liver fibrosis is a common pathological process in almost all chronic liver diseases, and is characterized as overproduction and abnormal distribution of extracellular matrix (ECM) in the liver [7].…”

Comparative pharmacokinetics of three alkaloids in normal and acute hepatitis rats after oral administration of Yanhuanglian total alkaloids extract

“…It has been reported that pharmacokinetics may be influenced by pathological status (Shi et al, ), such as type 2 diabetes (Deng et al, ) and non‐alcoholic fatty liver disease (Yang et al, ). Acute hepatitis is a common pathological process in almost all liver diseases, and is characterized as ballooning degeneration of cytoplasm in the liver (Fonseca, Dias, Gonçalves, Albuquerque, & Gama, ).…”