Comparative pharmacognostical studies on three different plant sources of Pashanbhed

Abstract

Background:Pashanbhed is a commercially available diuretic and lithotropic drug, used to treat renal problems. It is a controversial name as it is assigned to various plants such as Bergenia ligulata, Kalanchoe pinnata, Coleus aromaticus and Rotula aquatica.Objective:To perform the comparative preliminary phytochemical screening, diuretic activity, and thin layer chromatography (TLC) finger printing profile of three plants (B. ligulata, C. aromaticus, and K. pinnata), most commonly used as Pashanbhed.Materials and Methods:Diuretic potential of methanolic extract (ME) of three plants were evaluated at two dose levels (500 and 1,000 mg/kg p.o.), using normal Wistar rats (Lipschitz method). Furosemide (20 mg/kg p.o.) was used as a standard drug. The effect on urine output and electrolyte changes were measured for 24 h and compared. All MEs were screened preliminarily for their constituents and their TLC finger printing profiles were prepared. One-way analysis of variance (ANOVA) followed by Bonferroni's multiple comparison test. P < 0.05 was considered statistically significant.Results:The MEs of all three plants have shown diuresis in normal rats. However, in intercomparison of the ME C. aromaticus (1,000 mg/kg p.o.) produced more significant diuresis (P < 0.05) and electrolyte excretion compared to other test groups, the effect was at par with furosemide. The ME of these plants showed presence of alkaloids, glycosides, steroids, terpenoids, saponins, flavonoids, etc.Conclusion:The ME of C. aromaticus (1,000 mg/kg p.o.) has showed highest diuretic action (4.2) among the tested extracts. This suggests the use of C. aromaticus leaves as “Pashanbhed”; the most effective diuretic drug.

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“…merupakan salah satu tanaman dari suku Crassulaceae yang tumbuh dengan baik didaerah beriklim sedang dan tropis. Cocor bebek umumnya digunakan sebagai tanaman hias (Pinilih & Hidayat, 2014;Kistanti H, 2012), namun juga berkhasiat mengobati bisul, penyembuhan luka, rematik, penyakit kulit, batu empedu, batu ginjal, diabetes (Okwu & Nnamdi, 2011;Prasad et al, 2014;Sharker et al, 2012;Verma et al, 2014). Aktivitas farmakologi dari daun cocor bebek juga telah dilaporkan sebagai antikanker, antivirus, antimikroba, antiinflamasi dan antioksidan (Bhatti et al, 2012;Okwu & Nnamdi, 2011;Rajsekhar et al, 2016;Singh et al, 2019).…”

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“…merupakan salah satu tanaman dari suku Crassulaceae yang tumbuh dengan baik didaerah beriklim sedang dan tropis. Cocor bebek umumnya digunakan sebagai tanaman hias (Pinilih & Hidayat, 2014;Kistanti H, 2012), namun juga berkhasiat mengobati bisul, penyembuhan luka, rematik, penyakit kulit, batu empedu, batu ginjal, diabetes (Okwu & Nnamdi, 2011;Prasad et al, 2014;Sharker et al, 2012;Verma et al, 2014). Aktivitas farmakologi dari daun cocor bebek juga telah dilaporkan sebagai antikanker, antivirus, antimikroba, antiinflamasi dan antioksidan (Bhatti et al, 2012;Okwu & Nnamdi, 2011;Rajsekhar et al, 2016;Singh et al, 2019).…”

Investigation of potential anti-urolithiatic activity from different types of Musa pseudo-stem extracts in inhibition of calcium oxalate crystallization

“…Most of the remedies used in traditional medicine systems are taken from plants although they do not have strong clinical evidences to support their causes. However, many remedies produced from plants have a positive effect on patients, especially some composite plants and herbal drugs such as Herniaria hirsuta where the extract can reduce the crystal size [ 3 ], Bergenia ligulata [ 40 ], Piper nigrum [ 23 ], Dolichos biflorus [ 12 ], Plantago major [ 45 ] etc. Previously, most of the studies were carried out in vivo using animal or human [ 27 ].…”