Comparative performance of QuantiFERON-TB Gold versus skin test with tuberculosis recombinant allergen (Diaskintest) among patients with suspected pulmonary tuberculosis in Russia

Nikitina, I. Yu.; Karpina, Natalya; Kasimceva, Olga V.; Gergert, V. Ya.; Ergeshov, Atadzhan; Lyadova, Irina V.

doi:10.1016/j.ijid.2019.06.014

Cited by 20 publications

(15 citation statements)

References 20 publications

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“…The accuracy of QFT-Plus and PPD-based TST was estimated from meta-analyses 15 , 25 , 26 . The sensitivity and specificity of the two recombinant tuberculin proteins were considered to be similar to QFT-Plus, as the same antigens are used and head-to-head studies show similar test-positivity rates 19 , 27 , 28 . Although no studies have been performed comparing the tests on people living with HIV, this similarity is likely to be maintained.…”

Section: Methodsmentioning

confidence: 99%

Cost-effectiveness of newer technologies for the diagnosis of Mycobacterium tuberculosis infection in Brazilian people living with HIV

Steffen

Pinto

Kritski

et al. 2020

Sci Rep

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Tuberculosis is the leading cause of death among people living with HIV (PLH). Preventive tuberculosis therapy reduces mortality in PLH, especially in those with a positive tuberculin skin test (TST). New, more specific technologies for detecting latent tuberculosis infection (LTBI) are now commercially available. We sought to analyse the cost-effectiveness of four different strategies for the diagnosis of LTBI in PLH in Brazil, from the Brazilian public health care system perspective. We developed a Markov state-transition model comparing four strategies for the diagnosis of LTBI over 20 years. The strategies consisted of TST with the currently used protein purified derivative (PPD RT 23), two novel skin tests using recombinant allergens (Diaskintest [Generium Pharmaceutical, Moscow, Russia] and EC [Zhifei Longcom Biologic Pharmacy Co., Anhui, China]), and the QuantiFERON-TB-Gold-Plus (Qiagen, Hilden, Germany). The main outcome was cost (in 2020 US dollars) per quality-adjusted life years (QALY). For the base case scenario, the Diaskintest was dominant over all other examined strategies. The cost saving estimate per QALY was US $1375. In sensitivity analyses, the Diaskintest and other newer tests remained cost-saving compared to TST. For PLH, TST could be replaced by more specific tests in Brazil, considering the current national recommendations.

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Section: Methodsmentioning

confidence: 99%

Cost-effectiveness of newer technologies for the diagnosis of Mycobacterium tuberculosis infection in Brazilian people living with HIV

Steffen

Pinto

Kritski

et al. 2020

Sci Rep

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“…Therefore, like IGRAs, they are unaffected by a prior BCG vaccination or contacts with environmental mycobacteria [ 46 ]. Moreover, their accuracy for the diagnosis of TB infection is similar to that of IGRAs [ 39 , 47 , 48 ]. Like TST, the Diaskin test, EC-skin test and c-Tb tests can be used in large-scale screening settings, are cost-effective and do not need the infrastructure of a laboratory.…”

Section: What New Tests Are Available To Diagnose Tb Infection?mentioning

confidence: 99%

The definition of tuberculosis infection based on the spectrum of tuberculosis disease

Migliori

Ong

Petrone

et al. 2021

Breathe

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Latent tuberculosis infection was the term traditionally used to indicate tuberculosis (TB) infection. This term was used to define “a state of persistent immune response to stimulation by Mycobacterium tuberculosis antigens through tests such as the tuberculin skin test (TST) or an interferon-γ release assay (IGRA) without clinically active TB”. Recent evidence indicates that the spectrum from TB infection to TB disease is much more complex, including a “continuum” of situations didactically reported as uninfected individual, TB infection, incipient TB, subclinical TB without signs/symptoms, subclinical TB with unrecognised signs/symptoms, and TB disease with signs/symptoms. Recent evidence suggests that subclinical TB is responsible for important M. tuberculosis transmission. This review describes the different stages described above and their relationships. It also summarises the new developments in prevention, diagnosis and treatment of TB infection as well as their public health and policy implications.Educational aimsTo describe the evolution of the definition of “tuberculosis infection” and didactically describe the continuum of stages existing between TB infection and disease.To discuss the recommended approaches to prevent, diagnose and treat TB infection.

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“…The Diaskin test indicates the accuracy of the diagnosis and the severity of tuberculosis [ 23 ]. Our study shows the association between the positive Diaskin test and the ADR occurrence, which might be due to the severity of the disease.…”

Section: Discussionmentioning

confidence: 99%

Adverse Drug Reactions among Children with Tuberculosis in Tashkent, Uzbekistan, 2019

Abdusalomova

Denisiuk

Davtyan³

et al. 2021

IJERPH

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The treatment of childhood tuberculosis can be challenging due to the lack of pediatric drug formulations and monitoring of drug-toxicity in routine settings. There are no published studies from Uzbekistan on the adverse drug reactions (ADR) associated with anti-tuberculosis treatment in children. In this study, we aimed to investigate the ADR associated with anti-tuberculosis treatment in children. This was a cohort study using secondary program data of children treated at the city and regional tuberculosis clinics in Tashkent, Uzbekistan. Of the 302 patients evaluated, 135 (44.7%) reported ADR. New tuberculosis was registered in 277 (92%) patients and 262 (87%) had extrapulmonary tuberculosis. Factors associated with ADR included treatment at a regional hospital (adjusted odds ratio, aOR = 1.75; p = 0.026), female sex (aOR = 2.2; p = 0.004), and treatment with second-line drugs (aOR = 8.82; p < 0.001). The most common ADRs were gastrointestinal disorders (28.5%) followed by hepatitis (8.9%) and dermatologic reactions (8.6%). Most of the ADRs were mild (55.6%) or moderate (43.7%), only one child had severe ADR. Patients with the identified risk factors should be closely monitored during the treatment. We also recommend expansion of ADR surveillance throughout the country for more representative data in the future.

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Comparative performance of QuantiFERON-TB Gold versus skin test with tuberculosis recombinant allergen (Diaskintest) among patients with suspected pulmonary tuberculosis in Russia

Cited by 20 publications

References 20 publications

Cost-effectiveness of newer technologies for the diagnosis of Mycobacterium tuberculosis infection in Brazilian people living with HIV

Cost-effectiveness of newer technologies for the diagnosis of Mycobacterium tuberculosis infection in Brazilian people living with HIV

The definition of tuberculosis infection based on the spectrum of tuberculosis disease

Adverse Drug Reactions among Children with Tuberculosis in Tashkent, Uzbekistan, 2019

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