Comparative performance of lab tests and blood testing device to monitor glucose, total cholesterol and triacylglycerol in type 2 diabetic patients

Abstract

The performance of lab tests (LT) and blood testing devices (BTD) to monitor glycemia vs. glycated hemoglobin A1c (A1c) were compared. In addition, the performance of blood glucose, total cholesterol (TC) and triacylglycerol measured by LT and BDT were compared. All parameters were measured based on the same blood samples from overnight fasted type 2 diabetic patients (T2DP). Linear regression analysis was used for all comparisons. The results showed that A1c correlated better with LT-glucose (r = 0.58) than BTD-glucose (r = 0.42). Moreover, LT vs. BTD showed r values of 0.90, 0.82 and 0.92 for glucose, TC and triacylglycerol, respectively. It was concluded that the performance of LT-glucose was better than BDT-glucose. Moreover, since triacylycerol and TC measured by BTD correlated better with LT compared to BDT-glucose vs. LT-glucose, the inclusion of BTD-TC and BTD-triacylglycerol for detecting and monitoring hyperlipidemia in T2DP should be considered.Uniterms: Laboratory tests. Glycated hemoglobin. Glycemia. Total cholesterol. Triacylglycerol. Type 2 diabetes.Comparou-se a performance de avaliação da glicemia através de dosagens laboratoriais (DL) ou dispositivo para teste de sangue capilar (DTSC) vs. hemoglobina glicada A1c (A1c). Comparou-se ainda a performance de avaliação da glicemia, colesterol total (CT) e triacilglicerol (DL vs. DTSC). Avaliou-se estes parametros a partir das mesmas amostras de sangue coletadas em pacientes diabéticos tipo 2 (PDT2) em jejum noturno, sendo as comparações realizadas através de análise de regressão linear. A A1c correlacionou-se melhor com a glicemia-DL (r = 0,58) em relação a glicemia-DTSC (r = 0,42). Comparou-se DL vs. DTSC obtendo se r = 0,90, 0,82 e 0,92 para glicemia, CT e triacilglicerol, respectivamente. Concluiu-se que houve melhor performance da glicose-DL em relação a glicose-DTSC. Além disso, considerando que o triacilglicerol e TC avaliado através de DTSC correlaciona-se melhor com DL em comparação a DTSC-glicose vs. DL-glicose, a inclusão de DTSC-TC e DTSC-triacilglicerol visando detectar e monitorar hyperlipidemia in PDT2 deve ser considerada.

Pharmaceutical consultation as a tool to improve health outcomes for patients with type 2 diabetes

“…The contribution made by each strategy cannot be evaluated, but results showed that providing diabetes education and reinforcing lifestyle changes can help patients optimize metabolic control in a country where only 0.2% of T2DP simultaneously reach targets for glycemia, lipidemia, and blood pressure (Gomes et al, 2006). Additional details on the contribution by each method can be found in Zubioli (2011).…”

“…For this reason, we adopted T2D as a model of disease where the pharmacist could help improve standard medical care (Silva, Bazotte, 2011;Zubioli et al, 2011). In this context, the Dader method could provide adjustments for improving glycemic control (Fornos et al, 2006).…”

Blood levels of pro-inflammatory and anti-inflammatory cytokines during an oral glucose tolerance test in patients with symptoms suggesting reactive hypoglycemia

“…Blood glucose, glycated hemoglobin A1c, total cholesterol and triacylglycerol were determined as previously described ( 16 ). Quantitative measurement of cortisol, ACTH, C-peptide and insulin were done using chemiluminescence enzyme immunoassay kits for use on the Immulite® and Immulite® 1000 systems (Siemens, USA).…”