Comparative pathology of dog and human prostate cancer

Ryman-Tubb, Toby; Lothion-Roy, Jennifer; Metzler, Veronika M.; Harris, Anna E.; Robinson, Brian D.; Rizvanov, Albert A.; Jeyapalan, Jennie N.; James, Victoria; Persson, Jenny L.; Kenner, Lukas; Rubin, Mark A.; Mongan, Nigel P.; Brot, Simone de

doi:10.1002/vms3.642

Cited by 19 publications

(16 citation statements)

References 96 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Human and canine prostate glands share many functional, anatomical and physiological features and BPH is one of the most important problems in both intact male dogs and men [26,27]. Oxidative stress have been considered to play a role in the development of BPH in men [10][11][12][13].…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress biomarkers in dogs with benign prostatic hyperplasia

et al. 2022

View full text Add to dashboard Cite

Background The aim of this study was to evaluate total antioxidant capacity (TAC) and biomarkers of lipid and protein peroxidation in the blood serum of dogs with benign prostatic hyperplasia (BPH). The study was conducted on 36 intact male dogs of various breeds. The dogs were assigned to two groups: BPH group (n = 18) and non-affected group (n = 18). Blood samples were collected from the cephalic vein. The antioxidant status of the serum was assessed using TAC. The levels of bityrosine, formylkynurenine and SH-groups were used as protein peroxidation biomarkers and the level of radical cations of N,N-diethyl-paraphenylene diamine (RC-DEPPD) was used as a marker for lipid peroxidation. TAC and the concentrations of SH-groups and RC-DEPPD in the serum were determined spectrophotometrically, the concentrations of bityrosine and formylokynurenine, were determined using spectrofluorimetric methods. Results The mean value of TAC in the serum was significantly lower (P = 0.01) in BPH dogs than in non-affected dogs (3.10 ± 0.56 vs 4.20 ± 1.60 μmol/g protein). Mean levels of protein and lipid oxidation biomarkers showed a trend towards oxidative imbalance, but there were no statistically significant differences between dogs with BPH and controls (P > 0.05). Conclusion In conclusion, significantly lower serum TAC in dogs with BPH compared to non-affected dogs suggests a potential involvement of oxidative stress in the pathogenesis of BPH in dogs. More studies are needed to clarify the role of oxidative stress in the development of BPH in dogs.

show abstract

Section: Discussionmentioning

confidence: 99%

Oxidative stress biomarkers in dogs with benign prostatic hyperplasia

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The prostate gland is essential for the success of fertilization, and its main role is the production of prostatic fluid, which functions for sperm survival and sperm transport during ejaculation [4,22]. The glandular epithelium of the prostate gland is composed of luminal (secretory), basal, and neuroendocrine (NE) cells [ 8,13,26,38,52]. The luminal cells are the most abundant epithelial cells, which often display cuboidal to columnar shapes and basal nuclei.…”

Section: Introductionmentioning

confidence: 99%

“…In dogs, luminal cells secrete prostatic fluid containing multiple substances, such as cholesterol, citrate, lactate, and canine prostate-specific arginine esterase, which is the homolog of prostate-specific antigen (PSA) [16,18]. Basal cells located on the basement membrane are the second most abundant epithelial cells, which are involved in the survival of luminal cells, express p63 protein, and show the discontinuous layer in dogs, unlike in humans [32,41,52]. NE cells are rare, secrete chromogranin A and synaptophysin, and control the exocrine of secretory cells and prostate differentiation and growth [9,13,26,52].…”

Section: Introductionmentioning

confidence: 99%

“…Basal cells located on the basement membrane are the second most abundant epithelial cells, which are involved in the survival of luminal cells, express p63 protein, and show the discontinuous layer in dogs, unlike in humans [32,41,52]. NE cells are rare, secrete chromogranin A and synaptophysin, and control the exocrine of secretory cells and prostate differentiation and growth [9,13,26,52].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Seasonal changes of the prostate gland in the raccoon (<i>Procyon lotor</i>) inhabiting Hokkaido, Japan

Sasaki

Yamaguchi

Matsumoto

et al. 2023

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

In the prostate gland of the raccoon (Procyon lotor), the morphological appearance of the epithelial cells, such as basal and luminal cells, and the expressions of p63, androgen receptor (AR), and proliferating cell nuclear antigen (PCNA) were examined histologically and immunohistochemically to clarify their seasonal dynamics throughout the year. In this study, the regression with luminal cell defluxion and the regeneration process of the prostatic glandular epithelium was revealed in the seasons with declined spermatogenesis (June to August). The expression of p63 was observed only in the basal cells. AR immunoreactivity in the luminal cells was shown in the developed and regenerating (close to developed) prostates, whereas the basal cells exhibited AR immunoreactivity all year round. PCNA expression was rare in epithelial cells of the developed prostate gland. In the regressed gland, the basal cells demonstrated proliferative ability, whereas PCNA of the luminal cells appeared for the first time in the regenerating phase. This study is the first to clarify the regression with luminal cell defluxion and restoration and the seasonal dynamics of AR expression and proliferative activity in the prostate gland of seasonal breeders.

show abstract

“…According to the World Health Organization, prostate cancer had the highest incidence rate of 1 in 9.3 worldwide, assuming both sexes as the criterion and without the specified range of the criterion [ 8 ]. In prostate cancer, cell growth is a hormonal receptor-stimulated disease [ 9 , 10 ], and it is one of the few types of neoplasms for which no clear etiological factors can be indicated [ 11 , 12 ]. Histopathological examination is the basis for the diagnosis of prostate cancer, in which adenocarcinoma is mainly diagnosed.…”

Section: Introductionmentioning

confidence: 99%

An Analysis of the Effects of In Vitro Photodynamic Therapy on Prostate Cancer Tissue by Histopathological Examination and Magnetic Resonance Imaging

Aebisher

Osuchowski

Bartusik‐Aebisher

et al. 2022

IJMS

View full text Add to dashboard Cite

Prostate cancer can significantly shorten the lifetime of a patient, even if he is diagnosed at an early stage. The development of minimally-invasive focal therapies such as photodynamic therapy to reduce the number of neoplastic cells while sparing delicate structures is extremely advantageous for treating prostate cancer. This study investigates the effect of photodynamic therapy performed in prostate tissue samples in vitro, using quantitative magnetic resonance imaging and histopathological analysis. Prostate tissue samples were treated with oxygenated solutions of Rose Bengal (RB) or protoporphyrin IX disodium salt (PpIX), illuminated with visible light, and then analyzed for changes in morphology by microscopy and by measurement of spin–lattice and spin–spin relaxation times at 1.5 Tesla. In the treated prostate tissue samples, histopathological images revealed chromatin condensation and swelling of the stroma, and in some cases, thrombotic necrosis and swelling of the stroma accompanied by pyknotic nuclei occurred. Several samples had protein fragments in the stroma. Magnetic resonance imaging of the treated prostate tissue samples revealed differences in the spin–lattice and spin–spin relaxation times prior to and post photodynamic action.

show abstract

Comparative pathology of dog and human prostate cancer

Cited by 19 publications

References 96 publications

Oxidative stress biomarkers in dogs with benign prostatic hyperplasia

Oxidative stress biomarkers in dogs with benign prostatic hyperplasia

Seasonal changes of the prostate gland in the raccoon (<i>Procyon lotor</i>) inhabiting Hokkaido, Japan

An Analysis of the Effects of In Vitro Photodynamic Therapy on Prostate Cancer Tissue by Histopathological Examination and Magnetic Resonance Imaging

Contact Info

Product

Resources

About