Comparative pathology of canine mammary tumours

Nerurkar, Vivek R.; Chitale, Arun R.; Jalnapurkar, B.V.; Naik, Sujata; Lalitha, V.

doi:10.1016/0021-9975(89)90022-4

Cited by 59 publications

(51 citation statements)

References 13 publications

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“…Canine mammary gland carcinomas have epidemiological, clinical, and morphologic features that are similar to those of human breast carcinoma, for which they are suitable natural models (19,24). Although accumulating evidence indicates that mammary carcinomas in genetically modified mice provide good models of similarities to human mammary carcinomas (2), mouse models have some limitations when exploring the precise mechanisms of tumorigenesis.…”

Section: Discussionmentioning

confidence: 99%

“…Chromosomal aneuploidy is found in canine mammary tumors (25), and it is very likely that repair proteins, such as BRCA2 and Rad51, are involved in the etiology of canine mammary tumors. As mammary tumors in dogs resemble human adenocarcinoma more closely than experimentally induced cancer in inbred laboratory animals, the dog is a suitable animal for studying human breast cancer (19,24). In addition, recent advances in the analysis of the dog genome emphasize the value of dogs as experimental models (13,22).…”

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confidence: 99%

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Insertion/deletion polymorphism in the BRCA2 nuclear localization signal

et al. 2005

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Mutations in human BRCA2 confer an increased risk of female breast cancer. In this study, we found a novel insertion/deletion polymorphism (10204insAAA causing amino acid change M3332IK) in canine BRCA2, which is located in the putative second nuclear localization signal (NLS2) and C-terminal Rad51-binding region. The nuclear localization of the insAAA C-terminus was more efficient than localization of the delAAA sequence when NLS1 was mutated. Strong, comparable Rad51 binding was observed for both the insAAA and delAAA C-termini. Dogs with the insertion/deletion polymorphism will provide a new model for studying the function of BRCA2.The human breast cancer susceptibility gene BRCA2 encodes a large tumor-suppressor protein of 3,418 amino acids (1, 27, 31). The BRCA2 protein plays important roles in the maintenance of genomic stability in DNA recombination and double strandbreak repair through its interaction with Rad51 recombinase (4,17,27,28,31,33). BRCA2 interacts with Rad51 via eight BRC repeats in the central region (4, 27, 31). An independent interaction with Rad51 via the extreme C-terminus of Brca2 was believed to be a mouse-specific event (4, 16, 28), but a recent study of human BRCA2 demonstrated an interaction via the C-terminus (8). This interaction has been shown to regulate Rad51 nucleoprotein filament formation and the nuclear transport of Rad51 (6,29,33,35). Loss of BRCA2 function via mutation leads to genomic instability and tumorigenesis (1,18,27,31).The BRCA2 protein is localized to the nucleus, which is consistent with its role in DNA recombination and repair (4, 26). In human BRCA2, three nuclear localization signals (NLSs) have been identified and named NLS1, NLS2, and NLS3. Spain et al. (30) and Yano et al. (34) demonstrated the roles of these NLSs in human BRCA2 using GFP-tagged sequences, and suggested a relationship between the mislocalization of BRCA2 and tumorigenesis. In fact, the smallest reported cancer-associated mutation is a truncation that removes 224 residues containing the three NLSs from the C-terminal (11). Therefore, truncation mutations, which constitute the majority of tumorigenic mutations of BRCA2, prevent localization of BRCA2 to the nucleus and consequently result in dysfunction (10,30,34).

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Insertion/deletion polymorphism in the BRCA2 nuclear localization signal

et al. 2005

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“…Virchow postulated that osseous metaplasia arises from fibroblasts, i.e., osteoblasts are modified fibroblasts. Osseous metaplasia may arise directly from fibroblasts or from cartilage [6,7].…”

Section: Discussionmentioning

confidence: 99%

“…malignant mesenchymoma, osteoid sarcoma [9], osteogenic sarcoma [10], and osteochondrosarcoma [1]. Very few cases of osseous sarcoma are reported in benign lesions such as fibroadenoma, pleomorphic adenoma, benign mesenchymoma [11], phyllodes tumor [12], and amyloid tumor of the breast [7]. Approximately 200 cases of osseous metaplasia have been reported, most of which were reported as arising in fibroadenomas, phyllodes tumors, and sarcomas [13].…”

Section: Discussionmentioning

confidence: 99%

Benign osseous metaplasia of the breast: Case report

Alyami

AL-Osail

Harbi

et al. 2018

International Journal of Surgery

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“…In comparative research on human and canine mammary tumours (CMTs), it was reported that CMTs are better suited than rodent models to the evaluation of the molecular mechanism of carcinogenesis (10,11,19).…”

Section: Introductionmentioning

confidence: 99%

Investigation of human papillomaviruses (HPV), mouse mammary tumour virus (MMTV), Epstein–Barr virus (EBV), and human polyomavirus entities in canine mammary tumours

Sönmez¹,

Altan

Yıldırım³

et al. 2016

Journal of Veterinary Research

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Introduction: The aim of the study was to investigate the presence of human papillomaviruses (HPV), mouse mammary tumour virus (MMTV), Epstein-Barr virus (EBV), and human polyomavirus BK in canine mammary tumours (CMTs) and to correlate the results of histopathological classification with the results of virological examination. Material and Methods: Eighty CMTs and ten normal canine mammary gland samples were evaluated using histopathological methods and TaqMan real-time PCR analysis. Results: The results indicated that all mammary tumours and normal mammary tissue samples were negative for HPV16 and other HPV, EBV, human polyomavirus, and human mammary tumour virus strains. Conclusion: Further studies should be performed to investigate the existence of other strains of HPV, EBV, and human polyomavirus in CMTs.

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Comparative pathology of canine mammary tumours

Cited by 59 publications

References 13 publications

Insertion/deletion polymorphism in the BRCA2 nuclear localization signal

Insertion/deletion polymorphism in the BRCA2 nuclear localization signal

Benign osseous metaplasia of the breast: Case report

Investigation of human papillomaviruses (HPV), mouse mammary tumour virus (MMTV), Epstein–Barr virus (EBV), and human polyomavirus entities in canine mammary tumours

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