“…However, hepatic microscopical lesions were more severe (degeneration and necrosis of hepatocytes, substantial infiltration of inflammatory and red blood cells) compared to the current study. The findings of pathogenicity study in Muscovy ducklings are consistent with previous studies declaring recent alteration of pathogenicity criteria of DHAV-1 (31,35,39,40). Differences in the severity of gross and microscopic lesions between duckling species could be attributed to the degree of host adaptability considering that both tested DHAV-1 strains were isolated from Pekin ducklings.…”
Section: Discussionsupporting
confidence: 89%
“…Interestingly, recent variant strains belonging to the genetic group 3 were associated with pancreatitis and encephalitis, accompanied by 25-40% mortalities with no significant liver lesions (20,21,24). The pancreatitis-type DHAV-1 in Muscovy ducklings is now defined to be a distinct type from conventional hepatitis type (22,23,35). Other variant viruses also caused hepatitis in pigeons and egg drop syndrome in laying ducks (36,37).…”
Hisham et al. Pathogenicity of Egyptian DHAV-1 Strains these data provide updated information on the genetic diversity and pathotyping of Egyptian DHAV-1 strains. To the best of our knowledge, this is the first report of comparative pathogenicity of recent DHAV-1 strains in Pekin and Muscovy ducklings in Egypt and the Middle East region.
“…However, hepatic microscopical lesions were more severe (degeneration and necrosis of hepatocytes, substantial infiltration of inflammatory and red blood cells) compared to the current study. The findings of pathogenicity study in Muscovy ducklings are consistent with previous studies declaring recent alteration of pathogenicity criteria of DHAV-1 (31,35,39,40). Differences in the severity of gross and microscopic lesions between duckling species could be attributed to the degree of host adaptability considering that both tested DHAV-1 strains were isolated from Pekin ducklings.…”
Section: Discussionsupporting
confidence: 89%
“…Interestingly, recent variant strains belonging to the genetic group 3 were associated with pancreatitis and encephalitis, accompanied by 25-40% mortalities with no significant liver lesions (20,21,24). The pancreatitis-type DHAV-1 in Muscovy ducklings is now defined to be a distinct type from conventional hepatitis type (22,23,35). Other variant viruses also caused hepatitis in pigeons and egg drop syndrome in laying ducks (36,37).…”
Hisham et al. Pathogenicity of Egyptian DHAV-1 Strains these data provide updated information on the genetic diversity and pathotyping of Egyptian DHAV-1 strains. To the best of our knowledge, this is the first report of comparative pathogenicity of recent DHAV-1 strains in Pekin and Muscovy ducklings in Egypt and the Middle East region.
“…Previous studies performed on DHAV have focused only on the pathogenicity and the host response to DHAV-1 infection. The comparative pathogenicity of DHAV-1 and DHAV-1s strains in the ducklings of different species has been well documented [14,15]. However, the different mechanisms between DHAV-1 and DHAV-1s strains remain unknown.…”
Background: Duck hepatitis A virus type 1 (DHAV-1) causes a highly contagious disease in domestic ducklings, which is traditionally characterized by lesions in the liver and rarely in the pancreas. However, several outbreaks of DHAV-1, which were characterized by yellow coloration and hemorrhage in pancreatic tissues, have occurred in China. Genomic sequencing indicated variation rates of 3.4-6.5% in the genome of the novel DHAV-1 compared with those of DHAV-1. The antigenic relationship between the novel DHAV-1 and DHAV-1 indicated large variation. Therefore, the novel DHAV-1 was named as DHAV-1 subtype (DHAV-1s). However, the mechanism involved in infection of DHAV-1s is still unclear. Results: In the present study, transcriptome analysis of duck pancreas infected with DHAV-1 and DHAV-1s was carried out. Following deep sequencing with Illumina-Solexa, a total of 53.9 Gb clean data were obtained from the cDNA library of the pancreas and a total of 29,597 unigenes with an average length of 993.43 bp were generated following de novo sequence assembly. The expression levels of D-3-phosphoglyceratedehydrogenase, phosphoserine aminotransferase, phosphoserine phosphatase, which are involved in glycine, serine and threonine metabolism pathway, were significantly downregulated in the DHAV-1s-infected group compared with those of the DHAV-1-infected group.Conclusion: These findings provide information regarding differential expression levels of metabolism-associated genes between the novel DHAV-1s and DHAV-1, indicating that intensive metabolism disorders may contribute to different phenotypes of DHAV-1-infection.
“…In 2015, several strains of human HAV have been found in seals, which may indicate that the first natural nonprimate HAV to be discovered, and provide further understanding for the evolutionary history and pathogenicity of HAV [98]. Moreover, in recent years, HAV-associated hepatoviruses have been found in bats, rodents, hedgehogs [38], duck [99][100][101], and woodchucks [102,103], which suggested that there may be more candidate animals potentially used as animal models of HAV. On the contrary, some scholars believed that these new viruses are substantially more divergent from each other and from human HAV (including simian HAV), which is in accordance with them being assigned to several additional species in taxonomy [78].…”
Hepatitis diseases are remaining in the list of significant threats to human health. Human hepatitis viruses are basically classified into six major hepatotropic pathogens-hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), hepatitis E virus (HEV), and hepatitis G virus (HGV). Among these different forms of hepatotropic viruses, HAV as the leading cause of acute viral hepatitis is characterized as a kind of tiny ribonucleic acid virus that is linked to atopic disease. As we know, animal models have been instrumental in promoting understanding of complex host-virus interactions and boosting the advancement of immune therapies. So far, animal models such as nonhuman primates (NHPs) have enabled scientists to mimic and study the pathogenicities and host immune responses for hepatitis A infection. With the exception of chimpanzees and marmosets, animals like mice, pigs, guinea pigs, and tree shrews can also be selected as alternative animal models infected with HAV under laboratory conditions. In order to gain a better insight into hepatitis A pathogenesis and relevant contents, this chapter is mainly focused on the research progress in animal models of hepatitis A, and discusses the merits and demerits of these alternative models.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.