Comparative pathogenesis of three Mayaro virus genotypes in the cynomolgus macaque
Melissa M. Hamilton,
Emily M. Webb,
Max C. Peterson
et al.
Abstract:Mayaro virus (MAYV), a mosquito-borne alphavirus, is considered an emerging threat to public health with epidemic potential. Phylogenetic studies show the existence of three MAYV genotypes. In this study, we provide a preliminary analysis of the pathogenesis of all three MAYV genotypes in cynomolgus macaques (Macaca facicularis, Mauritian origin). Significant MAYV-specific RNAemia and viremia were detected during acute infection in animals challenged intravenously with the three MAYV genotypes, and strong neut… Show more
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