Comparative outcomes of carotid artery stenting for asymptomatic and symptomatic carotid artery stenosis: a single-center prospective study

Mo, Dapeng; Wang, Bo; Ma, Ning; Gao, Feng; Miao, Zhongrong

doi:10.1136/neurintsurg-2014-011437

Cited by 5 publications

(3 citation statements)

References 17 publications

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“…Sakai et al 10 found that the risk of any stroke was 5.7% within 30 days after CAS, whereas it was only 1.6% from 31 days to 1 year. Mo et al 11 also published the rates of composite vascular event (stroke, AMI, and death) after CAS which were 1.5% within 30 days and 4.5% under mean 18.3 months of follow-up. Long-term outcomes after international carotid stenting study (ICSS trial) demonstrated that cumulative 1-year stroke rate was 9.5%; however, if it only included patients >30 days post-CAS, the rate was found to be 2.9%.…”

Section: Discussionmentioning

confidence: 99%

Is Extended Duration of Dual Antiplatelet Therapy After Carotid Stenting Beneficial?

et al. 2015

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The optimal antithrombotic regimen after carotid artery stenting (CAS) remains uncertain. We aimed to elucidate if long-term duration of aspirin plus clopidogrel after CAS would provide clinically relevant benefit.Patients receiving CAS were identified from the National Health Insurance Research Database, Taiwan. The discharge date following CAS was defined as index date. The study participants were divided into groups according to the prescribed duration of antiplatelet after the index date. They included the insufficient (<30 days), moderate (30–41 days), and considerable (≥42 days) groups. The risk of ischemic stroke, composite vascular outcome, and death were interested outcomes. To eliminate event-related prescription change, all outcomes that occurred within 42 days were excluded. Follow-up started 42 days after the index date and was censored when an event occurred or at 6 months.A total of 4903 patients received CAS from 2004 to 2011. The total participants recruited for analysis (n = 2829) included the insufficient (n = 688), moderate (n = 372), and considerable groups (n = 1769). The event rates of ischemic stroke (3.92, 2.69, and 2.77%, P = 0.30), composite vascular stroke (5.52, 4.03, and 4.41%, P = 0.42), and death (3.05, 2.42, and 2.32%, P = 0.58) were similar for each group. Cox regression did not demonstrate significant associations between antiplatelet duration and the outcomes of interest.Long-term use of aspirin plus clopidorel after CAS did not decrease the risk of ischemic stroke, composite vascular events, or death during 6 months of follow-up. More research on the appropriate duration of post-CAS dual antiplatelet is essential.

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Section: Discussionmentioning

confidence: 99%

Is Extended Duration of Dual Antiplatelet Therapy After Carotid Stenting Beneficial?

et al. 2015

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“…12,13 Moreover, the follow-up time in most of the published studies in China is less than 2 years, and few data has identified the safety of CAS among the older patients. [12][13][14] Therefore, we aimed to compare the demographic and clinical characteristics, and periprocedural and an extending 5-year event rates between younger (<70 years) and older (≥70 years) patients treated by CAS at a single institution to testify the safety of CAS in older patients in China.…”

Section: Introductionmentioning

confidence: 99%

Age and Five-Year Outcomes After Carotid Artery Stenting in Symptomatic Carotid Stenosis: A Retrospective Cohort Study

Liu¹,

Zhu

Ma³

et al. 2022

Vasc Endovascular Surg

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Background Several clinical trials have reported that periprocedural risk of carotid artery stenting (CAS) increase with age. China is experiencing one of the most rapid transitions to an aging society, while the clinical outcomes of CAS in real-world China are still limited. The study aimed to compare the periprocedural and an extending 5-year event rates between younger and older patients treated by CAS to testify the safety of CAS in older patients in China. Methods This is a single center, retrospective cohort study. Symptomatic patients who underwent CAS from Nov 2011 to June 2014 were retrospectively included in this study, The population was divided into two age groups: <70 and ≥70. The main primary endpoint was stroke, myocardial infarction or death occurring at 30 days, or ipsilateral stroke over 5-year after stenting. Results A total of 103 symptomatic patients (<70: 68%; ≥70: 32%) with CAS included in the study. During the 30-day period, the rate of primary outcome was 1.0% with only one stroke in patients younger than 70 years old ( P = 1.000). After five years, the rate of primary outcome was low (10.9%, 10/92) despite some of the patients had major stroke or underwent bilateral C1 stenting. There was no significant difference in the 5-year rates of the primary outcome between the young and old groups (12.3% vs 7.4%, P = .718). Kaplan-Meier estimates of the proportion of study participants with a primary endpoint showed that there was no significant age-dependent difference of the stroke and death outcome in symptomatic patients. Conclusions Age (<70 vs ≥ 70) had no influence on the risk of stroke or death in symptomatic patients either in the short or long term. CAS is an optimal treatment for older patients with cervical carotid artery stenosis, and CAS was safe for those with major stroke or bilateral C1 stenting.

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“…Karotid arter stenozu genel olarak geriatrik hasta grubunda görülen bir hastalıktır [1,2]. Karotid stenozu tedavisinde gerek endarterektomi ve stentleme etkin bir yöntem olup karşılaştırmalı pek çok çalışma mevcuttur [3,4]. Karotid stenozu tedavisinde stent ile tedavinin getirdiği morbidite ve mortalite riskinde yaşa bağlı bir artış olup olmadığı hakkında randomize ve çift kör çalışmalar oldukça kısıtlıdır.…”

Section: Introductionunclassified

Karotis stentlemede yaş ve peroperatif morbidite İlişkisi

Orhan¹,

Dağlıoğlu²

2018

Turkish Journal of Clinics and Laboratory

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Comparative outcomes of carotid artery stenting for asymptomatic and symptomatic carotid artery stenosis: a single-center prospective study

Abstract: Periprocedural and long-term follow-up outcomes of CAS appear similar for ACS and SCS.

Cited by 5 publications

References 17 publications

Is Extended Duration of Dual Antiplatelet Therapy After Carotid Stenting Beneficial?

Is Extended Duration of Dual Antiplatelet Therapy After Carotid Stenting Beneficial?

Age and Five-Year Outcomes After Carotid Artery Stenting in Symptomatic Carotid Stenosis: A Retrospective Cohort Study

Karotis stentlemede yaş ve peroperatif morbidite İlişkisi

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