The Altaids is generally considered to be the largest Phanerozoic accretionary orogen on Earth, but it is unclear if it was associated with extensive continental crustal growth and whether there is a link between the crustal growth and ore mineralization. This paper reviews whole-rock Nd and zircon Hf isotope data for felsic-intermediate-mafic igneous rocks in the Altaids and presents Nd + Hf isotopic contour maps for this region. The maps highlight the three-dimensional (3D) lithospheric compositional architecture of the Altaids and make it possible to quantitatively evaluate the crustal growth and its relationship to ore deposits. The Altaids hosts ∼4 107 350 km2 and ∼184 830 750 km3 (assuming a crustal thickness of 40-50 km) juvenile crust (ϵNd(t) > 0), accounting for 58% by isotope-mapped area (∼7 010 375 km2) of almost all outcrops of the Altaids (∼8 745 000 km2) and formed during 1000–150 Ma (mainly 600–150 Ma). The juvenile crustal, slightly juvenile-reworked crustal, and slightly reworked crustal provinces controlled the Cu-Au, the Pb-Zn-Ag, and the Li-Be, Nb-Ta, and W-Sn ore deposits. According to the crustal architecture and background of deep compositions, we propose that the ore deposits can be grouped into three types: juvenile crust-related, mixed source (or slightly juvenile crust)-related, and reworked crust-related. This highlights the close relationship between accretion, continental growth, and mineralization and will facilitate exploration for specific ore deposit types in the Altaids.