Comparative Ontogensis of Structure-Function Relations in Cerebral and Cerebeller Cortex

Purpura, Dominick P.; Shofer, R.J.; Housepian, Edgar M.; Noback, Charles R.

doi:10.1016/s0079-6123(08)61277-7

Cited by 99 publications

(43 citation statements)

References 38 publications

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“…This study has confirmed previous studies on changes of cranial capacity up to adulthood in various primates [Z u c k erm a n, 1926, 1928G a u l , 1933;Z uckerman and F isher, 1937;D a v en po rt, 1940;Sc h u l t z , 1940bSc h u l t z , , 1941. Ontogenetic studies [Purpura et al" 1964] further confirm the conclusion that brain growth can continue up to adulthood even though it is generally assumed that an individual is born with a fixed, irreplaceable number of neurons.…”

Section: Growth O F the Brainmentioning

confidence: 79%

Relationship between Growth of Brain and Skull of <i>Macaca mulatta,</i>and its Importance for the Stereotaxic Technique

1975

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An analysis of the brain weight of 196 rhesus monkeys and lateral X-rays of 91 more was made to determine and correct the effect of growth and development on stereotaxic variability. A comparison of body weight to brain weight shows that the brain grows rapidly initially in a linear relationship with body weight and can increase in weight even into adulthood, with a significant amount of variability found throughout its development. The examination of the cranial base and stereotaxic reference points indicates that the brain rotates during growth in a forward and downward direction in relation to the stereotaxic planes. The distance between the anterior clinoid process and AP-0 shows an increase of little variability from linearity during growth. This distance can be used to correct for the anterior-posterior plane found in standard stereotaxic atlases. The flattening out of the cranial base results in a horizontal plane readjustment during growth. A horizontal correction can be made by measuring the distance between the base of the pituitary fossa and H-10 plane.

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Section: Growth O F the Brainmentioning

confidence: 79%

Relationship between Growth of Brain and Skull of <i>Macaca mulatta,</i>and its Importance for the Stereotaxic Technique

1975

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“…Purpura et al (26) found that Purkinje cell dendrites expand greatly in the 8-to 12-day period. Schapiro and Vukovich (27) found that dendritic spine density in pyramidal cells of the visual cortex increases sharply starting around day 8 or 9.…”

Section: Brain Growth Datamentioning

confidence: 99%

Rodent Brain Growth Stages: An Analytical Review

Gottlieb¹,

Keydar²,

Epstein³

1977

Neonatology

174

101

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Study of data in the literature on rat and mouse brain growth from birth to weaning reveals a stagewise growth in average brain weight. Rapid growth occurs in the intervals between days 0–6, 8–12, and 17–23 after birth. Slow growth periods then lie in the intervals 6–8, 12–17, and after 23 days. The first slow growth period is signalled by events occurring at its end: substantial acceleration of synthesis of RNA, DNA, protein, and myelin. The second slow growth period is characterized by at least a 3-day interval during which there is very little increase in average brain weight compared with what occurs just before and just after that period; the correlation among 12 studies is highly significant. Implications are discussed for cross-species’ extrapolation of findings about brain development.

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“…Purkinje cell development and afferent input have been studied extensively in mice [29,30], rats [31][32][33][34][35], kittens [36][37][38][39][40] and primates [41,42]. The distal dendritic branchlets are covered with spines, which are contacted by parallel fiber axons of granule cells [41].…”

Section: Discussionmentioning

confidence: 99%

Dendritic Alterations of Cerebellar Purkinje Neurons in Postnatally Lead-Exposed Kittens

Patrick

Anderson²

2000

Dev Neurosci

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Many investigations have sought to determine the effect of lead exposure on the development of the cerebellum. This study addresses the effects of postnatal lead exposure in kittens on dendritic development of Purkinje cells. Golgi-Cox filled cells were used to measure dendritic branching patterns, spine density, height, width and distance from the cerebellar surface. The results revealed a significant increase in spine density and altered patterns of dendritic branching. Complex dendritic branching was evident with a progressive shift in peak branching peripherally. Lead-exposed Purkinje cells showed early sprouting with subsequent pruning. At 5 weeks of age dendritic branches on experimental cells were increased along the entire dendritic extent. Control Purkinje cells showed initial sprouting with subsequent pruning. Normal developmental growth spurts and lead-induced effects were evident on dendritic height, width and distance from the surface. Cerebella stained with hematoxylin and eosin and cresyl violet acetate showed no evidence of vascular damage or other pathologies. These findings corroborate the evidence of hyperspiny dendritic formation representing an important mechanism of neuronal plasticity. In regard to morphological effects of lead on rodents, the hyperspiny Purkinje cell dendrites and patterns of dendritic growth in lead-treated kittens offer an alternative interpretation of neurobehavioral findings of lead-burdened children. The results are discussed with reference to other aspects of lead exposure and neural development.

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Comparative Ontogensis of Structure-Function Relations in Cerebral and Cerebeller Cortex

Cited by 99 publications

References 38 publications

Relationship between Growth of Brain and Skull of <i>Macaca mulatta,</i>and its Importance for the Stereotaxic Technique

Relationship between Growth of Brain and Skull of <i>Macaca mulatta,</i>and its Importance for the Stereotaxic Technique

Rodent Brain Growth Stages: An Analytical Review

Dendritic Alterations of Cerebellar Purkinje Neurons in Postnatally Lead-Exposed Kittens

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