Comparative nasal absorption of allergens in atopic and nonatopic subjects

Kontou-Karakitsos, Kalliopi; Salvaggio, John E.; Mathews, Kenneth P.

doi:10.1016/0091-6749(75)90143-8

Cited by 37 publications

(17 citation statements)

References 17 publications

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“…It has been postulated that the entry of allergens is prevented by nasal impermeability (16,38) or by specific nasal IgA ab (13)(14)(15)(16). Our own data make it most unlikely that nonallergic persons are prevented from becoming allergic by the presence of nasal ab Although some experiments had suggested that nasal permeability was lower in nonallergic individuals (38,39), this has not been confirmed by direct experiments (40). Animal experiments generally show that optimal antigen doses for IgE ab formation will also produce other classes of ab in responding strains (9,41) but will produce no response of any class in nonresponding strains (9).…”

Section: Discussioncontrasting

confidence: 45%

IgA and IgG anti-ragweed antibodies in nasal secretions. Quantitative measurements of antibodies and correlation with inhibition of histamine release.

Platts‐Mills¹,

Maur²,

Ishizaka³

et al. 1976

J. Clin. Invest.

156

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A B S T R A C T Total secretory IgA and specific antiantigen E (AgE) antibodies (ab) Blocking activity in the nasal washings was measured by inhibition of histamine release and was found to correlate directly (ra + 0.85, P <0.001) with binding activity for AgE. Some washings from normal persons caused slight inhibition of histamine release but others caused enhancement. Nasal washings were fractionated by passage over Sephadex G-200.

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Section: Discussioncontrasting

confidence: 45%

IgA and IgG anti-ragweed antibodies in nasal secretions. Quantitative measurements of antibodies and correlation with inhibition of histamine release.

Platts‐Mills¹,

Maur²,

Ishizaka³

et al. 1976

J. Clin. Invest.

156

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“…Similarly, already in 1975, indications of reduced nasal airway absorption in patients with allergic rhinitis had been demonstrated. 9 In accord with this, significantly reduced absorption permeability was observed in patients with seasonal rhinitis along with plasma exudation and allergic symptoms. In these studies absorption tracer concentration, influence of mucociliary clearance, exposed airway surface area, and exposure time were controlled.…”

Section: Airway Plasma Exudation and Absorption In Patients With Asthmentioning

confidence: 62%

“…[2][3][4][5][6] Similarly, nasal absorption permeability has not been increased in patients with seasonal or perennial rhinitis. [7][8][9][10] This in vitro-in vivo dichotomy ought to have some bearing on several areas of research. However, the iconoclastic in vivo data demonstrating maintained epithelial barrier function in patients with asthma or allergic rhinitis are not extensively noted in the current literature.…”

mentioning

confidence: 99%

Airways exudation of plasma macromolecules: Innate defense, epithelial regeneration, and asthma

Persson

2019

Journal of Allergy and Clinical Immunology

107

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This review discusses in vivo airway aspects of plasma exudation in relation to current views on epithelial permeability and epithelial regeneration in health and disease. Microvascular-epithelial exudation of bulk plasma proteins characteristically occurs in asthmatic patients, being especially pronounced in those with severe and exacerbating asthma. Healthy human and guinea pig airways challenged by noninjurious histamine-leukotriene-type autacoids also respond through prompt mucosal exudation of nonsieved plasma macromolecules. Contrary to current beliefs, epithelial permeability in the opposite direction (ie, absorption of inhaled molecules) has not been increased in patients with asthma and allergic rhinitis or in acutely exuding healthy airways. A slightly increased subepithelial hydrostatic pressure produces such unidirectional outward perviousness to macromolecules. Lack of increased absorption permeability in asthmatic patients can further be reconciled with occurrence of epithelial shedding, leaving small patches of denuded basement membrane. Counteracting escalating barrier breaks, plasma exudation promptly covers the denuded patches. Here it creates and sustains a biologically active barrier involving a neutrophil-rich, fibrin-fibronectin net. Furthermore, in the plasma-derived milieu, all epithelial cell types bordering the denuded patch dedifferentiate and migrate from all sides to cover the denuded basement membrane. However, this speedy epithelial regeneration can come at a cost. Guinea pig in vivo studies demonstrate that patches of epithelial denudation regeneration are exudation hot spots evoking asthma-like features, including recruitment/activation of granulocytes, proliferation of fibrocytes/smooth muscle cells, and basement membrane thickening. In conclusion, nonsieved plasma macromolecules can operate on the intact airway mucosa as potent components of first-line innate immunity responses. Exuded plasma also takes center stage in epithelial regeneration. When exaggerated, epithelial regeneration can contribute to the inception and development of asthma.

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“…Among the asthmatic children, increased intestinal permeability did not correlate with asthma severity, treatment with inhaled steroids, associated eczema, or allergy as indicated by positive SPT. Although many investigators have studied the permeability of nasal and respiratory mucosa in atopy, 17 reports of evaluation of the intestinal permeability in bronchial asthma are scarce. To our knowledge, the only study in the literature on intestinal permeability in asthma is that of Benard and colleagues 6 in France.…”

Section: Discussionmentioning

confidence: 99%

Intestinal permeability is increased in bronchial asthma

Hijazi

Molla²,

Al-Habashi³

et al. 2004

Archives of Disease in Childhood

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Background: Increased intestinal permeability has been reported in one study of adult asthmatics. Aim: To determine whether children with asthma have altered intestinal permeability. Methods: Thirty two asthmatic children, and 32 sex and age matched controls were recruited. The dual sugar (lactulose and mannitol) test was used to evaluate intestinal permeability, and the percentage of ingested lactulose (L) and mannitol (M) in the urine, and the L:M ratio were determined. All patients were skin prick tested for common aeroallergens, and specific IgE to some food items was determined. Results: The median value of L in asthmatic children (2.29, IQR 0.91-4.07) was significantly higher than that in controls (0.69, IQR 0.45-1.08), and that of M was almost similar. The ratio L:M was significantly higher in asthmatic children (0.20, IQR 0.11-0.40) than in controls (0.06, IQR 0.04-0.09). Intestinal permeability did not correlate with eczema, inhaled steroids, positive skin prick test to aeroallergens, or severity of asthma. Conclusions: Intestinal permeability is increased in children with asthma, suggesting that the whole mucosal system may be affected.

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Comparative nasal absorption of allergens in atopic and nonatopic subjects

Cited by 37 publications

References 17 publications

IgA and IgG anti-ragweed antibodies in nasal secretions. Quantitative measurements of antibodies and correlation with inhibition of histamine release.

IgA and IgG anti-ragweed antibodies in nasal secretions. Quantitative measurements of antibodies and correlation with inhibition of histamine release.

Airways exudation of plasma macromolecules: Innate defense, epithelial regeneration, and asthma

Intestinal permeability is increased in bronchial asthma

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