Comparative mutagenic and genotoxic effects of three propionic acid derivatives ibuprofen, ketoprofen and naproxen

Philipose, B; Singh, R. P.; Khan, K.A.; Giri, Ashok K.

doi:10.1016/s1383-5718(97)00095-8

Cited by 37 publications

(12 citation statements)

References 26 publications

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“…According to the EPA and GenPharmTox guidelines, the over twofold increase in mutant frequency in the same experiment indicates the mutagenic potential of the compound (Lah et al 2005). In our study, similarly to Philipose et al (1997), no mutagenic activity of ibuprofen was demonstrated in tests with Salmonella strains (Table 5). …”

Section: Resultssupporting

confidence: 90%

Toxicity and biodegradation of ibuprofen by Bacillus thuringiensis B1(2015b)

Marchlewicz

Guzik

Hupert-Kocurek

et al. 2017

Environ Sci Pollut Res

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In recent years, the increased intake of ibuprofen has resulted in the presence of the drug in the environment. This work presents results of a study on degradation of ibuprofen at 25 mg L−1 in the presence of glucose, as an additional carbon source by Bacillus thuringiensis B1(2015b). In the cometabolic system, the maximum specific growth rate of the bacterial strain was 0.07 ± 0.01 mg mL−1 h−1 and K sμ 0.27 ± 0.15 mg L−1. The maximum specific ibuprofen removal rate and the value of the half-saturation constant were q max = 0.24 ± 0.02 mg mL−1 h−1 and K s = 2.12 ± 0.56 mg L−1, respectively. It has been suggested that monooxygenase and catechol 1,2-dioxygenase are involved in ibuprofen degradation by B. thuringiensis B1(2015b). Toxicity studies showed that B. thuringiensis B1(2015b) is more resistant to ibuprofen than other tested organisms. The EC50 of ibuprofen on the B1 strain is 809.3 mg L−1, and it is 1.5 times higher than the value of the microbial toxic concentration (MTCavg). The obtained results indicate that B. thuringiensis B1(2015b) could be a useful tool in biodegradation/bioremediation processes.

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Section: Resultssupporting

confidence: 90%

Toxicity and biodegradation of ibuprofen by Bacillus thuringiensis B1(2015b)

Marchlewicz

Guzik

Hupert-Kocurek

et al. 2017

Environ Sci Pollut Res

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“…In our study, none of the results of the Ames test exceeded the critical value, 2.0., and no mutagenic activity of diclofenac in Salmonella strains TA98 and TA100 was observed. These results are in accordance with the results of Philipose et al [24].…”

Section: Toxicity Of Diclofenacsupporting

confidence: 94%

Toxicity of Diclofenac and its Biotransformation by Raoultella sp. DD4

Domaradzka¹,

Hupert-Kocurek²,

Wojcieszyńska³

2016

Pol. J. Environ. Stud.

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“…[Parry and Sors, 1993;Gibson et al, 1995;Parry et al, 2002a,b]. The results of this micronucleus assay in vitro demonstrate the aneugenic activity of ibuprofen-DG, Ibuprofen itself has been found nonmutagenic in earlier studies using Ames test and weakly genotoxic in vivo in mice [Oldham et al, 1986;Philipose et al, 1997], and did not increase chromosomal aberrations in blood lymphocytes [Shvarts et al, 1984] which means this drug is nongenotoxic but when it is present in the form of xenobiotic diacylglycerols, then these conjugates can produce genotoxic effects.…”

Section: Discussionmentioning

confidence: 78%

In vitro genotoxic assessment of xenobiotic diacylglycerols in an in vitro micronucleus assay

Kayani

Parry

Vickery

et al. 2009

Environ and Mol Mutagen

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Xenobiotic diacylglycerols (DG) may induce pathological disorders by causing abnormal chromosomal segregation, which could be aneuploid. In this study, seven xenobiotic-diacylglycerols (four of drug origin and three of pesticide origin) were evaluated for their ability to induce aneuploidy in mammalian cultures using in vitro cytokinesis blocked micronucleus (CBMN) assay coupled with kinetochore labeling and interphase fluorescent in situ hybridization. Out of seven xeno-DGs, two (ibuprofen-DG and fenbufen-DG) induced statistically significant (P < 0.001) and dose-dependent increase in micronucleus induction, but this apparent micronucleus induction was very weak in case of fenbufen-DG. These MN were produced predominantly by aneugenic and clastogenic mechanisms, respectively, confirmed by immunofluorescent labeling of kinetochores. Fluorescent in situ hybridization analysis revealed that ibuprofen-DG induced significantly higher nondisjunction for chromosomes 10, 17, and 18. Other xenobiotic diacylglycerols (indomethacin-DG, salicylic acid-DG, 4-(2-methyl-4-chlorophenoxy) butanoic acid-DG (MCPB-DG), 2-(2-methyl-4-chlorophenoxy) propanoic acid-DG (MCPP-DG) and 2-(4-dichlorophenoxy)-butanoic acid-DG (2,4 DB-DG) did not induce micronuclei, but the concentrations tested did not reach levels that caused the marked growth suppression typically required for testing for regulatory testing purposes. However, the levels of growth suppression achieved were similar to that seen with ibuprofen-DG, which was positive. This study shows that xeno-DGs, which have been neglected in the past for their possible link to any pathological disorders, need serious assessment of their mutagenic potential.

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Comparative mutagenic and genotoxic effects of three propionic acid derivatives ibuprofen, ketoprofen and naproxen

Cited by 37 publications

References 26 publications

Toxicity and biodegradation of ibuprofen by Bacillus thuringiensis B1(2015b)

Toxicity and biodegradation of ibuprofen by Bacillus thuringiensis B1(2015b)

Toxicity of Diclofenac and its Biotransformation by Raoultella sp. DD4

In vitro genotoxic assessment of xenobiotic diacylglycerols in an in vitro micronucleus assay

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