Comparative mutagenesis of quinolines

Epler, J.L.; Winton, W.; Ho, Ti; Larimer, Frank W.; Rao, T.K.; Hardigree, A.A.

doi:10.1016/0165-1110(77)90009-4

Cited by 46 publications

(5 citation statements)

References 14 publications

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“…The potential mutagenic and carcinogenic hazards posed by heterocyclic compounds have been revealed by various studies conducted in different test systems (Epstein and Pierre 1969, Hirao 1976, Epler et al 1977. The mutagenic activities of quinoline, isoquinoline and many others quinoline derivatives were tested using Salmonella typhimurium tester strains, TA 100 and TA 98 (Nagao et al 1977).…”

Section: Discussionmentioning

confidence: 99%

Clastogenic activity of quinoline, isoquinoline and pyridine.

et al. 1990

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Section: Discussionmentioning

confidence: 99%

Clastogenic activity of quinoline, isoquinoline and pyridine.

et al. 1990

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“…Creosote is a complex mixture consisting of approximately 3% heterocyclic compounds, 12% phenolic compounds, and 85% polycyclic aromatic hydrocarbons (PAHs) [2]. Many of the nitrogen-heterocyclic compounds are toxic [3][4][5], teratogenic [4], mutagenic [6,7], and/or carcinogenic [8].…”

Section: Introductionmentioning

confidence: 99%

Effects of Cations, Temperature, and Creosote on Degradation of Indole by Desulfobacterium Indolicum (Dsm 3383)

Licht¹,

Arvin²,

Ahring³

1997

Environ Toxicol Chem

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Abstract-This work describes the activity of Desulfobacterium indolicum under different conditions. Hydroxylation of indole by the sulfate-reducing marine bacterium D. indolicum was related to the concentration of Na ϩ and Mg 2ϩ , whereas K ϩ and Ca 2ϩ had no influence. Hydroxylation of indole by D. indolicum was possible in normal medium with cation concentrations corresponding to seawater at low temperatures (10-26ЊC). The effect of reduced cation concentrations was most pronounced at high temperatures (29 and 36ЊC) where only an incomplete hydroxylation was observed in the medium with reduced cation concentrations. Desulfobacterium indolicum was more sensitive to the presence of an artificial creosote mixture when depleted for cations. Sixty milligrams of artificial creosote per liter inhibited hydroxylation of indole by 30% in a normal growth medium compared to an 86% inhibition in a medium with low concentrations of cations. Indole and quinoline were the only compounds degraded from a creosote mixture consisting of 25 compounds. It was concluded that D. indolicum is active towards indole and quinoline under growth conditions quite distinct from its optimal laboratory conditions.

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“…Creosote is a complex mixture consisting of approximately 3% heterocyclic compounds, 12% phenolic compounds, and 85% polycyclic aromatic hydrocarbons (PAHs) [2]. Many of the nitrogen‐heterocyclic compounds are toxic [3–5], terato‐genic [4], mutagenic [6,7], and/or carcinogenic [8].…”

Section: Introductionmentioning

confidence: 99%

Effects of cations, temperature, and creosote on degradation of indole by Desulfobacterium indolicum (DSM 3383)

Licht

Arvin

Ahring

1997

Enviro Toxic and Chemistry

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This work describes the activity of Desulfobacterium indolicum under different conditions. Hydroxylation of indole by the sulfate‐reducing marine bacterium D. indolicum was related to the concentration of Na+ and Mg2+, whereas K+ and Ca2+ had no influence. Hydroxylation of indole by D. indolicum was possible in normal medium with cation concentrations corresponding to seawater at low temperatures (10‐26°C). The effect of reduced cation concentrations was most pronounced at high temperatures (29 and 36°C) where only an incomplete hydroxylation was observed in the medium with reduced cation concentrations. Desul‐fobacterium indolicum was more sensitive to the presence of an artificial creosote mixture when depleted for cations. Sixty milligrams of artificial creosote per liter inhibited hydroxylation of indole by 30% in a normal growth medium compared to an 86% inhibition in a medium with low concentrations of cations. Indole and quinoline were the only compounds degraded from a creosote mixture consisting of 25 compounds. It was concluded that D. indolicum is active towards indole and quinoline under growth conditions quite distinct from its optimal laboratory conditions.

show abstract

Comparative mutagenesis of quinolines

Cited by 46 publications

References 14 publications

Clastogenic activity of quinoline, isoquinoline and pyridine.

Clastogenic activity of quinoline, isoquinoline and pyridine.

Effects of Cations, Temperature, and Creosote on Degradation of Indole by Desulfobacterium Indolicum (Dsm 3383)

Effects of cations, temperature, and creosote on degradation of indole by Desulfobacterium indolicum (DSM 3383)

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