Comparative Mortality after 24-Hour, Whole-Body, Exposures of Mice to Fission Neutrons and Cobalt-60 Gamma-Rays

Vogel, Howard H.; Clark, John W.; Jordan, Donn L.

doi:10.2307/3570512

Cited by 25 publications

(1 citation statement)

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“…ber of studies (1)(2)(3)(4) have shown that for many short term biological responses in rats and mice (including acute lethality), irradiation with fast neutrons has an RBE of about 1.5 to 3.0, compared to X and y-irradiation. There has further been an opinion that for delayed or residual radiation effects the RBE for neutrons as compared to X and T-irradiation is much higher-perhaps as high as 13 or more (5).…”

Section: Introductionmentioning

confidence: 99%

Residual Injury Caused by Irradiation with Fast Neutrons

Krebs¹,

Bräuer²

1962

Radiation Research

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The LD50 of C 3H female mice for fission-spectrum neutrons was found to be 274.5 + 4.2 rad. The previously reported* value in the same mice for 250 kvp X-ray was 632 rad, giving an RM3 of 2.30.Conditioning exposure of the mice to a total neutron dose of 482.3 + 7.2 rad over an interval of 8-10 weeks resulted in lowering the LID for neutrons by 41.8 + 5.9 rad, or 8.67 + 1.23 percent of the total conditioning dose. The previously reported* value in the same mice for 250 kvp X-ray was 9.58 percent of the conditioning dose. Continued exposure of the mce to 166 rad doses of neutrons at intervals of 4-5 weeks gave a median survival time of 22 weeks. This was greater than that produced by exposure to 4 20 rad and less than that produced by exposure to 280 rad of 250 kvp X-ray given at the same time. It is concluded that the RBE of the mice for residual radiation injury and the RBE for chronic radiation tolerance over short time intervals are the same as that for acute injury tolerance.

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Section: Introductionmentioning

confidence: 99%