Comparative Metagenomic Screening of Aromatic Hydrocarbon Degradation and Secondary Metabolite-Producing Genes in the Red Sea, the Suez Canal, and the Mediterranean Sea

Elsaeed, Esraa; Enany, Shymaa; Hanora, Amro; Mahmoud, Nora F.

doi:10.1089/omi.2020.0070

Cited by 4 publications

(1 citation statement)

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“…For this purpose, bioinformatic programs have been used to analyse the DNA within an environmental or a microbiota sample, looking for BGCs in the context of metagenomic studies. Metagenomes offer the possibility of collecting a large amount of genetic information on the NRPS-PKS that can be found in a given ecosystem [72,73]. Beyond the constraints of culture, metagenomics allow for the exploration of the potential of yet uncultured, unknown species, giving a more accurate view of the entire reservoir of BGCs in a community [74].…”

Section: Metagenomic Strategy For Harnessing the Chemical Repertoire In The Environmentmentioning

confidence: 99%

In Silico/In Vitro Strategies Leading to the Discovery of New Nonribosomal Peptide and Polyketide Antibiotics Active against Human Pathogens

2021

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Antibiotics are majorly important molecules for human health. Following the golden age of antibiotic discovery, a period of decline ensued, characterised by the rediscovery of the same molecules. At the same time, new culture techniques and high-throughput sequencing enabled the discovery of new microorganisms that represent a potential source of interesting new antimicrobial substances to explore. The aim of this review is to present recently discovered nonribosomal peptide (NRP) and polyketide (PK) molecules with antimicrobial activity against human pathogens. We highlight the different in silico/in vitro strategies and approaches that led to their discovery. As a result of technological progress and a better understanding of the NRP and PK synthesis mechanisms, these new antibiotic compounds provide an additional option in human medical treatment and a potential way out of the impasse of antibiotic resistance.

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Section: Metagenomic Strategy For Harnessing the Chemical Repertoire In The Environmentmentioning

confidence: 99%