Comparative Metabolism of Intravenously Injected Promethium in Swine and Humans.

Abstract

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ICRP Publication 141: Occupational Intakes of Radionuclides: Part 4

“…The pattern of decline in the urinary excretion rate of promethium over the first several weeks in humans and large laboratory animals suggests a slow return to blood from tissues. A relatively high rate of faecal excretion in humans during the first 2 w but only slow loss from the body thereafter suggests an initially high rate of secretion into the gastrointestinal tract but substantially slower secretion thereafter. (252) McConnon and Cole (1971) compared the behaviour of intravenously injected PmCl 3 in swine and normal human subjects. No major differences were seen in the systemic biokinetics of promethium in the two species. (253) Stuart (1964) studied the biokinetics and adverse effects of 147 Pm in dogs following inhalation or intravenous injection of 147 Pm perchlorate.…”

“…(252) McConnon and Cole (1971) compared the behaviour of intravenously injected PmCl 3 in swine and normal human subjects. No major differences were seen in the systemic biokinetics of promethium in the two species.…”