Comparative material study and synthesis of 4-(4-nitrophenyl)oxazol-2-amine via sonochemical and thermal method

Singh, Balvant Shyam; Lobo, Hyacintha Rennet; Pinjari, Dipak V.; Jarag, Krishna J.; Pandit, Aniruddha B.; Shankarling, Ganapati S.

doi:10.1016/j.ultsonch.2012.09.002

Cited by 37 publications

(14 citation statements)

References 24 publications

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“…This offers a possible explanation for the increase of reaction rate observed for such heterocyclodehydration processes in DES media compared to the longer reaction times needed in VOCs, instead. The role of a DES as a catalytic active species has also been suggested for other reactions [41,43,44,45,46,47,48,49]. A plausible and simple mechanism of formation of 2-AIs 3 from α-chloroketones 1 and guanidines 2 is depicted in Scheme 1.…”

Section: Resultsmentioning

confidence: 85%

“…At the outset of this investigation, we were rather skeptical about the successful outcome of the reaction. In fact, it has been recently reported by Shankarling and co-workers that α-bromoketones are able to react with the urea component of a DES mixture to produce 2-aminooxazole derivatives as the final products [41]. In this case, a DES is a “non-innocent” medium as it becomes an integral part of the starting materials.…”

Section: Resultsmentioning

confidence: 99%

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An Expeditious and Greener Synthesis of 2-Aminoimidazoles in Deep Eutectic Solvents

et al. 2016

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Abstract:A high-yield one-pot two-step synthesis of 2-aminoimidazoles (2-AI), exploiting an under-air heterocyclodehydration process between α-chloroketones and guanidine derivatives, and using deep eutectic solvents (DESs) as nonconventional, "green" and "innocent" reaction media, has been accomplished successfully. The combination of either glycerol or urea with choline chloride (ChCl) proved to be effective for decreasing the reaction time to about 4-6 h in contrast to the 10-12 h usually required for the same reaction run in toxic and volatile organic solvents and under an argon atmosphere. In addition, the use of the ChCl-urea as a DES also enables the direct isolation of triaryl-substituted 2-AI derivatives by means of a simple work-up procedure consisting in filtration and crystallization, and allows the recycle of the DES mixture. A plausible mechanism highlighting the potential role played by hydrogen bonding catalysis has also been illustrated.

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Section: Resultsmentioning

confidence: 85%

Section: Resultsmentioning

confidence: 99%

An Expeditious and Greener Synthesis of 2-Aminoimidazoles in Deep Eutectic Solvents

et al. 2016

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“…[45] The reaction under ultrasound irradiation gave better results in shorter times than when using conventional heating.…”

Section: Des Reagentsmentioning

confidence: 97%

Deep Eutectic Solvents: The Organic Reaction Medium of the Century

et al. 2016

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This microreview summarizes the use of deep eutectic solvents (DES) and related melts in Organic Synthesis. This type of solvents combine the great advantages of other proposed environmentally benign alternative solvents, such as low toxicity, high availability, low inflammability, high recyclability, low volatility and low price, avoiding many disadvantages of these neoteric media. The fact that many of the components of the mixture come directly from Nature assures their biodegradability and renewability. The classification and distribution of the reactions in different sections along this microreview, as well as the emphasis paid to their scope, easily allows a general reader to understand the actual state of art, and the great opportunities opened, not only for academic proposes but also for industry.

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“…95 Thermal synthesis of oxazole derivatives using ChCl-U DES as reaction medium. 96 Esterification of carboxylic acids using ChCl-ZnCl 2 DES. 97 the last three decades to overcome these drawbacks, the incompatibility of starch with hydrophobic phases remains a major problem.…”

Section: Additivesmentioning

confidence: 99%

Deep eutectic solvents: designer fluids for chemical processes

Wazeer

Hayyan

Hadj-Kali

2017

J of Chemical Tech & Biotech

110

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The increasing demand for multi‐task green solvents has spurred the development of next‐generation liquid media such as deep eutectic solvents (DESs), which have recently attracted increased attention. DESs are mixtures of salts and complexing agents, having freezing points lower than those of starting individual components. Similarly to ionic liquids, DESs exhibit distinctive properties such as chemical and thermal stability, biodegradability, non‐flammability, and cost effectiveness. These features account for their wide range of applications, e.g. as extractants, reactants, catalysts, reaction media, additives, and lubricants. This review summarizes the recent research efforts directed at exploring the potential applications of DESs in various chemical processes. With the rapid publication of reports on this new generation of solvents, other roles also are expected to be seen sooner or later. © 2017 Society of Chemical Industry

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Comparative material study and synthesis of 4-(4-nitrophenyl)oxazol-2-amine via sonochemical and thermal method

Cited by 37 publications

References 24 publications

An Expeditious and Greener Synthesis of 2-Aminoimidazoles in Deep Eutectic Solvents

An Expeditious and Greener Synthesis of 2-Aminoimidazoles in Deep Eutectic Solvents

Deep Eutectic Solvents: The Organic Reaction Medium of the Century

Deep eutectic solvents: designer fluids for chemical processes

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