Comparative kinetics of oral benz(a)anthracene, chrysene and triphenylene in rats: Study with hydrocarbon mixtures

The Gulf Oil Spill

“…In general, tissue distribution of benzo [a]pyrene following inhalation exposure is qualitatively similar for different species Weyand and Bevan 1986Wolff et al 1989c). In general, orally absorbed PAHs were rapidly and widely distributed in the rat (Bartosek et al 1984;Withey et al 1991;Yamazaki and Kakiuchi 1989). Qualitative similarities in distribution among species suggest that distribution in humans would also be similar.…”

“…In general, orally absorbed benz[a]anthracene, chrysene, and pyrene were rapidly and widely distributed in the rat (Bartosek et al 1984;Withey et al 1991). Maximum concentrations of benz [a]anthracene and chrysene in perfused tissues, like the liver, blood, and brain, were achieved within l-2 hours after administration of high doses (76 and 152 mg/kg) (Bartosek et al 1984).…”

“…Maximum concentrations of benz [a]anthracene and chrysene in perfused tissues, like the liver, blood, and brain, were achieved within l-2 hours after administration of high doses (76 and 152 mg/kg) (Bartosek et al 1984).…”

“…Therefore, PAHs reach more-perfused tissues rapidly following exposure and are eliminated more slowly from less perfused tissues (Bartosek et al 1984). A large fraction of orally absorbed benzo[a]pyrene is believedto be transported by lipoproteins from the gastrointestinal tract to the blood via the thoracic duct lymph flow (Busbee et al 1990).…”

Absorption adjustment factor (AAF) distributions for polycyclic aromatic hydrocarbons (PAHS)

“…Bartosek and coworkers (Bartosek et al, 1984) administered benz(a)anthracene, chrysene, or triphenylene to female CD-COBS rats by stomach tube in an aqueous emulsion of 10% Pluronic F68 emulsifier and 90% olive oil. Animals were fasted for 24 hours prior to being given a single oral dose of the PAH.…”