Comparative investigations on different polymers for the preparation of fast-dissolving oral films

Abstract

This case study showed that hydroxypropyl methyl cellulose was the most suitable film-forming material for drug-free and caffeine-loaded films, providing fast dissolution films that were not sticky and were easy to handle.

Using USP I and USP IV for Discriminating Dissolution Rates of Nano- and Microparticle-Loaded Pharmaceutical Strip-Films

“…One of these new solid dosage forms, pharmaceutical strip-film products, has received much attention because of several advantages including rapid disintegration and dissolution in the oral cavity and increased bioavailability (32)(33)(34)(35). In this work, we present a comparison between the basket method and the flow-through cell dissolution apparatus for the dissolution analysis of polymer strip-films containing dispersed particles of griseofulvin (GF), taken as a model Biopharmaceutical Classification System (BCS) class II drug, with the ultimate goal of discriminating drug dissolution with respect to drug particle size.…”

Orodispersible dosage forms: biopharmaceutical improvements and regulatory requirements

“…For 278 example, the medium volume generally used is significantly larger (up to 0.5 L) than the few millilitres of 279 saliva present in the buccal cavity. Hence, several strategies were proposed to evaluate the ODx 280 disintegration in static or dynamic conditions (e.g.¸ shaking or swirling) [65], or using small volumes (from 2 281 to 25 mL) in Petri dish instead of the common vessels and sample holders as supports [66]. [61,62,[65][66][67][68][69].…”

“…Hence, several strategies were proposed to evaluate the ODx 280 disintegration in static or dynamic conditions (e.g.¸ shaking or swirling) [65], or using small volumes (from 2 281 to 25 mL) in Petri dish instead of the common vessels and sample holders as supports [66]. [61,62,[65][66][67][68][69]. In this context, it is noteworthy that pH 6.0 phosphate buffer solution is proposed as 290 dissolution medium as it is already reported for medicated chewing gums by the Ph.…”

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“…Besides, it is necessary to explain the role of each auxiliary element participating in forming the basis for the future film. [3,18] When creating a dosage form of a biodegradable film, such film-forming components as sodium carboxymethylcellulose and polyvinyl alcohol are most often used. Polyethylene oxide-400 and glycerol are used as dispersing agents and plasticizers.…”

“…While applying dental films, the polymeric base is gradually dissolved under the influence of saliva, and there is prolonged release and diffusion of the active pharmaceutical ingredient to the tissue of the mucous membrane of the oral cavity and paradontium. [18] Dental films have advantages over other traditional dental forms: They increase the bioavailability and effectiveness of active pharmaceutical ingredients, protect them from washing off with saliva, and at the same time allow using different therapeutic and physicochemical properties of the substance.…”