Comparative Investigation of pH–Dependent Availability of Pancreatic Enzyme Preparations In Vitro
Amy Todd,
Emma Bennett-Huntley,
Jonas Rosendahl
et al.
Abstract:This study aimed to compare different pancreatic enzyme preparations (PEPs) available in Germany regarding particle geometry and size, and to evaluate enzyme activity under physiologically relevant conditions in vitro. Pancreatic endocrine insufficiency is characterized by deficiency of pancreatic enzymes resulting in maldigestion. It is orally treated by pancreatic enzyme replacement therapy. The formulations differ in their physical properties and enzyme release behavior, potentially resulting in inconsisten… Show more
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