Comparative investigation of in vitro biotransformation of 14 components in Ginkgo biloba extract in normal, diabetes and diabetic nephropathy rat intestinal bacteria matrix

Tang, Daoquan; Yu, Yanyan; Zheng, Xiao-xiao; Wu, Jing; Li, Yinjie; Wu, Xiaowen; Du, Qian; Yin, Xiaoxing

doi:10.1016/j.jpba.2014.07.022

Cited by 31 publications

(19 citation statements)

References 27 publications

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“…The fluorescence intensity of C-dots decreases significantly with the increase in Kae concentration, revealing that the sensing system is sensitive to Kae. The fluorescence quenching data follows the typical Stern-Volmer behavior [58,59]: Table S1 compares the analytical performance of our developed method with some other reported methods for Kae determination [10,15,[60][61][62][63]. The LOD of the proposed method is lower than other methods except the HPLC-chemiluminescence detection method.…”

Section: Analytical Performancementioning

confidence: 93%

Sensitive determination of kaempferol using carbon dots as a fluorescence probe

Liu

Feng

Paau

et al. 2015

Talanta

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Section: Analytical Performancementioning

confidence: 93%

Sensitive determination of kaempferol using carbon dots as a fluorescence probe

Liu

Feng

Paau

et al. 2015

Talanta

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“…In vitro studies permit also to evaluate the active compounds biotransformation process, which greatly influence both compounds bioavability and efficacy. Indeed, some studies revealed that gut microbiota largely influence the anti‐diabetic compound activity (Tang et al ., ). Tang et al .…”

Section: Diabetes Pharmacological Treatmentsmentioning

confidence: 97%

“…Tang et al . () studied the Ginkgo biloba metabolism intestinal bacteria in male Sprague–Dawley rats, after diabetes induction with streptozotocin. A validated LC–ESI(−) MRM method was employed to perform the pharmacokinetic study of 14 active components: their results clearly demonstrated that the biotransformation was different in normal and diabetic rat intestinal bacteria.…”

Section: Diabetes Pharmacological Treatmentsmentioning

confidence: 99%

The role of mass spectrometry in studies of glycation processes and diabetes management

DaRonco

Crotti

Agostini

et al. 2018

Mass Spectrometry Reviews

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In the last decade, mass spectrometry has been widely employed in the study of diabetes. This was mainly due to the development of new, highly sensitive, and specific methods representing powerful tools to go deep into the biochemical and pathogenetic processes typical of the disease. The aim of this review is to give a panorama of the scientifically valid results obtained in this contest. The recent studies on glycation processes, in particular those devoted to the mechanism of production and to the reactivity of advanced glycation end products (AGEs, AGE peptides, glyoxal, methylglyoxal, dicarbonyl compounds) allowed to obtain a different view on short and long term complications of diabetes. These results have been employed in the research of effective markers and mass spectrometry represented a precious tool allowing the monitoring of diabetic nephropathy, cardiovascular complications, and gestational diabetes. The same approaches have been employed to monitor the non‐insulinic diabetes pharmacological treatments, as well as in the discovery and characterization of antidiabetic agents from natural products. © 2018 Wiley Periodicals, Inc. Mass Spec Rev 38:112–146, 2019.

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“…Other studies have focused on the pharmacokinetics of major active components. After metabolism by intestinal bacteria, prototype components decreased within a certain period of time (Tang et al, ). Different components showed different metabolic abilities by intestinal bacteria.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous quantification and semi‐quantification of amentoflavone and its metabolites in human intestinal bacteria by liquid chromatography Orbitrap high‐resolution mass spectrometry

Qian

Jiang

Zhu

et al. 2017

Biomedical Chromatography

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A quick, easy, effective method followed by ultra-high-pressure liquid chromatography coupled with linear ion trap-Orbitrap tandem mass spectrometry (UHPLC-LTQ-Orbitrap MS) was developed for the simultaneous identification and quantification of the metabolites produced by amentoflavone (AMF) in human intestinal bacteria from human feces. The method validated for quantification of AMF concerning precision, accuracy, recovery, matrix effect, stability and limits showed acceptable results. Compared with blank human intestinal bacteria chromatography, three metabolites were identified based on high-accuracy protonated precursors and multi-stage mass spectrometry (MS ) using the proposed strategy. At the same time, a new method was developed for semi-quantification of three metabolites. We describe the trend over 24 h of concentration-time curves for AMF and its metabolites. Moreover, the main metabolic pathway of AMF was clarified in human intestinal bacteria. The method was validated and successfully applied to the detection and quantification of AMF and its metabolites.

show abstract

Comparative investigation of in vitro biotransformation of 14 components in Ginkgo biloba extract in normal, diabetes and diabetic nephropathy rat intestinal bacteria matrix

Cited by 31 publications

References 27 publications

Sensitive determination of kaempferol using carbon dots as a fluorescence probe

Sensitive determination of kaempferol using carbon dots as a fluorescence probe

The role of mass spectrometry in studies of glycation processes and diabetes management

Simultaneous quantification and semi‐quantification of amentoflavone and its metabolites in human intestinal bacteria by liquid chromatography Orbitrap high‐resolution mass spectrometry

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