Comparative inhibition of influenza and parainfluenza virus replication by ribavirin in MDCK cells

Browne, Michael

doi:10.1128/aac.19.5.712

Cited by 17 publications

(10 citation statements)

References 15 publications

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“…Amantadine did not decrease URI disease severity in adult volunteers challenged with HPIV-1 even though it has some anti-HPIV activity at very high concentrations (330). Similarly, ribavirin has both in vitro and in vivo activity against HPIV (32,326). Furthermore, there have been anecdotal reports of decreased HPIV shedding and clinical improvement when infected immunocompromised patients were treated with aerosolized and oral ribavirin (41,42,227,336).…”

Section: Prevention and Treatmentmentioning

confidence: 99%

Parainfluenza Viruses

2003

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Human parainfluenza viruses (HPIV) were first discovered in the late 1950s. Over the last decade, considerable knowledge about their molecular structure and function has been accumulated. This has led to significant changes in both the nomenclature and taxonomic relationships of these viruses. HPIV is genetically and antigenically divided into types 1 to 4. Further major subtypes of HPIV-4 (A and B) and subgroups/genotypes of HPIV-1 and HPIV-3 have been described. HPIV-1 to HPIV-3 are major causes of lower respiratory infections in infants, young children, the immunocompromised, the chronically ill, and the elderly. Each subtype can cause somewhat unique clinical diseases in different hosts. HPIV are enveloped and of medium size (150 to 250 nm), and their RNA genome is in the negative sense. These viruses belong to the Paramyxoviridae family, one of the largest and most rapidly growing groups of viruses causing significant human and veterinary disease. HPIV are closely related to recently discovered megamyxoviruses (Hendra and Nipah viruses) and metapneumovirus

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Section: Prevention and Treatmentmentioning

confidence: 99%

Parainfluenza Viruses

2003

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“…Ribavirin, a related ribofuranosylcarboxamide, has a broad spectrum of antiviral activity (32), both in vitro (2,14,20,24) and in vivo (13,16,19,31,37), and is currently under clinical evaluation for safety and efficacy in humans. Recent studies have shown that ribavirin is remarkably effective clinically against influenza A and B (17,21), hepatitis (23), and respiratory syncytial virus infection (11).…”

mentioning

confidence: 99%

Broad-spectrum antiviral activity of 2-beta-D-ribofuranosylselenazole-4-carboxamide, a new antiviral agent

Kirsi¹,

North²,

McKernan³

et al. 1983

Antimicrob Agents Chemother

155

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The relative in vitro antiviral activities of three related nucleoside carboxamides, ribavirin (1-3-D-ribofuranosyl-1,2,4-triazole-3-carboxamide), tiazofurin (2-3-D-ribofuranosylthiazole-4-carboxamide), and selenazole (2-p-D-ribofuranosylselenazole-4-carboxamide), were studied against selected DNA and RNA viruses. Although the activity of selenazole against different viruses varied, it was significantly more potent than ribavirin and tiazofurin against all tested representatives of the families Paramyxoviridae (parainfluenza virus type 3, mumps virus, measles virus), Reoviridae (reovirus type 3), Poxviridae (vaccinia virus), Herpesviridae (herpes simplex virus types 1 and 2), Togaviridae (Venezuelan equine encephalomyelitis virus, yellow fever virus, Japanese encephalitis virus), Bunyaviridae (Rift Valley fever virus, sandfly fever virus [strain Sicilian], Korean hemorrhagic fever virus), Arenaviridae (Pichinde virus), Picornaviridae (coxsackieviruses B1 and B4, echovirus type 6, encephalomyocarditis virus), Adenoviridae (adenovirus type 2), and Rhabdoviridae (vesicular stomatitis virus). The antiviral activity of selenazole was also cell line dependent, being greatest in HeLa, Vero-76, and Vero E6 cells. Selenazole was relatively nontoxic for Vero, Vero-76, Vero E6, and HeLa cells at concentrations of up to 1,000 ,g/ml. The relative plating efficiency at that concentration was over 90%. The effects of selenazole on viral replication were greatest when this agent was present at the time of viral infection. The removal of selenazole from the medium of infected cells did not reverse the antiviral effect against vaccinia virus, but there was a gradual resumption of viral replication in cells infected with parainfluenza type 3 or herpes simplex virus type 1 (strain KOS). However, the antiviral activity of ribavirin against the same viruses was reversible when the drig was removed.

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“…As in the case of other paramyxoviruses, HPIV are susceptible to ribavirin, which is the commonest antiviral agent used clinically for severe infections. In vitro and in animal studies, ribavirin suppresses viral multiplication and improves survival of animals 259–261 . Immunocompromised patients with serious HPIV infections are treated with ribavirin given by the intravenous or aerosolized routes, though its efficacy has not been studied in randomized controlled trials 251,252,254,262 .…”

Section: Antiviral Therapy For Specific Pathogensmentioning

confidence: 99%