Comparative in vivo evaluation of propranolol hydrochloride after oral and transdermal administration in rabbits

Rao, P. Rama; Reddy, M. M.; Sistla, Ramakrishna; Diwan, Prakash V.

doi:10.1016/s0939-6411(03)00038-9

Cited by 32 publications

(8 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results are consistent with the previous findings where PNIPAM microgels and PLGA microparticles were able to increase drug retention in the epidermis and decrease the drug permeation through the skin; however, the mechanism for this effect remains unclear . Several studies have shown sustained and controlled release of drugs from transdermal patches that contained EC .…”

Section: Resultssupporting

confidence: 92%

Development and characterization of skin permeation retardants and enhancers: A comparative study of levothyroxine-loaded PNIPAM, PLA, PLGA and EC microparticles

Azarbayjani¹,

Khu

Chan

et al. 2011

Biopharm. Drug Dispos.

View full text Add to dashboard Cite

Polymeric microparticles suitable for topical and transdermal delivery systems were studied using poly D,L lactide (PLA), poly D,L lactide co glycoside (PLGA), poly (N-isopropylacrylamide) (PNIPAM) and ethyl cellulose (EC). Drug encapsulation efficacy, microparticle stability and skin permeation studies of levothyroxine loaded microparticles were carried out using excised human skin, and the skin permeation pattern was observed using confocal laser scanning microscopy. It was found that ethyl cellulose microparticles had the highest drug encapsulation and minimal drug leakage during the 14 week storage period. The PNIPAM microparticles had the lowest drug encapsulation efficiency and a fast degradation rate. The PLGA microparticles exhibited a temperature dependent drug leakage. Permeation studies using a flow-through diffusion cell indicated that the polymer transition temperature (T(g)) may influence the skin permeation rate of levothyroxine. Polyesters (PLA and PLGA) and PNIPAM acted as a skin penetration retardant and caused skin accumulation of the drug. These microparticles have potential use in skin formulations containing sunscreens and other active ingredients that are meant to be concentrated on the skin surface. However, skin permeation was observed from EC microparticles, therefore such polymers may be used as carriers in transdermal formulations to help achieve therapeutic concentrations of the drug in the plasma.

show abstract

Section: Resultssupporting

confidence: 92%

Development and characterization of skin permeation retardants and enhancers: A comparative study of levothyroxine-loaded PNIPAM, PLA, PLGA and EC microparticles

Azarbayjani¹,

Khu

Chan

et al. 2011

Biopharm. Drug Dispos.

View full text Add to dashboard Cite

show abstract

“…As a result, the PDGW matrix provides not only excellent adhesive performance and drug loading capacity, but also free interspace for drug diffusion. In addition, the PVP in PDGW matrix also can improve the drug flux because the anti-nucleating effect of PVP can convert the crystalline drug into amorphous state, which generally possesses a high thermodynamic activity that facilitates the permeation rate of drug through the skin (36). Moreover, the glycerol also acts as an enhancer in PDGW matrix because of its considerable role in changing the properties of the skin, which induces consequent swelling of corneocytes and enhances the drug penetration across the rat skin (37,38).…”

Section: Discussionmentioning

confidence: 99%

A Novel Hydrophilic Adhesive Matrix with Self-Enhancement for Drug Percutaneous Permeation Through Rat Skin

Zhang

Liu

et al. 2009

Pharm Res

View full text Add to dashboard Cite

show abstract

“…Fresh rabbit skin was always employed for the transdermal drug delivery experiment in vivo [ 50 – 52 ]. A New Zealand rabbit (male, 3 months old, 3.0 Kg) was purchased from XinHua experimental animal farms (Huadu District, Guangzhou City, China).…”

Section: Methodsmentioning

confidence: 99%

Fabrication of a Ti porous microneedle array by metal injection molding for transdermal drug delivery

Liu

Zhou

et al. 2017

PLoS ONE

View full text Add to dashboard Cite

Microneedle arrays (MA) have been extensively investigated in recent decades for transdermal drug delivery due to their pain-free delivery, minimal skin trauma, and reduced risk of infection. However, porous MA received relatively less attention due to their complex fabrication process and ease of fracturing. Here, we present a titanium porous microneedle array (TPMA) fabricated by modified metal injection molding (MIM) technology. The sintering process is simple and suitable for mass production. TPMA was sintered at a sintering temperature of 1250°C for 2 h. The porosity of TPMA was approximately 30.1% and its average pore diameter was about 1.3 μm. The elements distributed on the surface of TPMA were only Ti and O, which may guarantee the biocompatibility of TPMA. TPMA could easily penetrate the skin of a human forearm without fracture. TPMA could diffuse dry Rhodamine B stored in micropores into rabbit skin. The cumulative permeated flux of calcein across TPMA with punctured skin was 27 times greater than that across intact skin. Thus, TPMA can continually and efficiently deliver a liquid drug through open micropores in skin.

show abstract

Comparative in vivo evaluation of propranolol hydrochloride after oral and transdermal administration in rabbits

Cited by 32 publications

References 8 publications

Development and characterization of skin permeation retardants and enhancers: A comparative study of levothyroxine-loaded PNIPAM, PLA, PLGA and EC microparticles

Development and characterization of skin permeation retardants and enhancers: A comparative study of levothyroxine-loaded PNIPAM, PLA, PLGA and EC microparticles

A Novel Hydrophilic Adhesive Matrix with Self-Enhancement for Drug Percutaneous Permeation Through Rat Skin

Fabrication of a Ti porous microneedle array by metal injection molding for transdermal drug delivery

Contact Info

Product

Resources

About