Comparative in vitro genotoxicity study of ZnO nanoparticles, ZnO macroparticles and ZnCl2 to MDCK kidney cells: Size matters

Kononenko, Veno; Repar, Neža; Marušič, Nika; Drašler, Barbara; Romih, Tea; Hočevar, Samo B.; Drobne, Damjana

doi:10.1016/j.tiv.2017.01.015

Cited by 80 publications

(46 citation statements)

References 44 publications

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“…The cytotoxicity and genotoxicity potential of ZnONPs has been shown both in vitro and in vivo. 24,25 In further studies, ZnONPs have reduced cell viability in dose-dependent and time-dependent manner. 26 ZnONPs are suspected of increasing the expression of the metallothionein gene, which is considered a biomarker in metal-induced toxicity.…”

Section: Nanomaterials In Daily Life and Their Toxicitymentioning

confidence: 91%

Nanoparticles in Daily Life: Applications, Toxicity and Regulations

Gupta

Xie

2018

J Environ Pathol Toxicol Oncol

392

188

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At nanoscale, man-made materials may show unique properties that differ from bulk and dissolved counterparts. The unique properties of engineered nanomaterials not only impart critical advantages but also confer toxicity because of their unwanted interactions with different biological compartments and cellular processes. In this review, we discuss various entry routes of nanomaterials in the human body, their applications in daily life, and the mechanisms underlying their toxicity. We further explore the passage of nanomaterials into air, water, and soil ecosystems, resulting in diverse environmental impacts. Briefly, we probe the available strategies for risk assessment and risk management to assist in reducing the occupational risks of potentially hazardous engineered nanomaterials including the control banding (CB) approach. Moreover, we substantiate the need for uniform guidelines for systematic analysis of nanomaterial toxicity, in silico toxicological investigations, and obligation to ensure the safe disposal of nanowaste to reduce or eliminate untoward environmental and health impacts. At the end, we scrutinize global regulatory trends, hurdles, and efforts to develop better regulatory sciences in the field of nanomedicines.

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Section: Nanomaterials In Daily Life and Their Toxicitymentioning

confidence: 91%

Nanoparticles in Daily Life: Applications, Toxicity and Regulations

Gupta

Xie

2018

J Environ Pathol Toxicol Oncol

392

188

View full text Add to dashboard Cite

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“…The medium was then replaced with zinc nanoparticles at 12, 61, 123, 184, 369 and 737 μM. The results demonstrated that Zn compounds exerted considerable cytotoxicity at 369 μM and higher [83].…”

Section: Necrosis Assaymentioning

confidence: 99%

In vitro and in vivo toxicity assessment of nanoparticles

2017

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Nanotechnology has revolutionized gene therapy, diagnostics and environmental remediation. Their bulk production, uses and disposal have posed threat to the environment. With the appearance of these nanoparticles in the environment, their toxicity assessment is an immediate concern. This review is an attempt to summarize the major techniques used in cytotoxity determination. The review also presents a detailed and elaborative discussion on the toxicity imposed by different types of nanoparticles including carbon nanotubes, gold nanoparticles, silver nanoparticles, quantum dots, fullerenes, aluminium nanoparticles, zinc nanoparticles, iron nanoparticles, titanium nanoparticles and silica nanoparticles. It discusses the in vitro and in vivo toxological effects of nanoparticles on bacteria, microalgae, zebrafish, crustacean, fish, rat, mouse, pig, guinea pig, human cell lines and human. It also discusses toxological effects on organs such as liver, kidney, spleen, sperm, neural tissues, liver lysosomes, spleen macrophages, glioblastoma cells, hematoma cells and various mammalian cell lines. It provides information about the effects of nanoparticles on the gene-expression, growth and reproduction of the organisms.

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“…Figure a displayed the mechanism about the cytotoxicity of the complex system containing ZnO NPs under various conditions. There is DNA damage when cells are stimulated by inducing agents like ZnO NPs . It can be seen from the observation of nuclear changes by the 4,6‐diamidino‐2‐ phenylindole (DAPI) staining results (Figure a, the blue; Figure S2, Supporting Information) that the addition of organic acid (ZnO NPs & TA, ZnO NPs & CA) increases the toxicity of ZnO NPs.…”

Section: Resultsmentioning

confidence: 99%

Safety Issue of Changed Nanotoxicity of Zinc Oxide Nanoparticles in the Multicomponent System

Huang

Ding

et al. 2019

Part & Part Syst Charact

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When nanomaterials are exposed to complex systems, such as food, they may cause significant changes in physical and chemical properties and even toxicity. The toxicity evaluation of complex systems is urgent. Unfortunately, so far, there is no database established about the toxicity changes of nanoparticles in composite systems. In this paper, the changes and toxicity mechanism of zinc oxide nanoparticles (ZnO NPs) in a composite system are studied. The results show that the dissolution of zinc ions (Zn2+) in acidic systems (vitamin C, tartaric acid, or citric acid) increases the toxicity of ZnO NPs. However, the toxicity of ZnO NPs is reduced by the complexation effect with Zn2+ in phosphoric acid, phosphate, and glutathione systems. The influence of titanium dioxide nanoparticles (TiO2 NPs) on the toxicity of ZnO NPs depends on size and surface properties. In brief, the intracellular Zn2+ homeostasis level is the decisive factor in determining the toxicity change in complex systems. The results indicate that the toxicity changes are very different in combined systems, which may have potential food safety issues, especially for unstable nanoparticles.

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Comparative in vitro genotoxicity study of ZnO nanoparticles, ZnO macroparticles and ZnCl2 to MDCK kidney cells: Size matters

Cited by 80 publications

References 44 publications

Nanoparticles in Daily Life: Applications, Toxicity and Regulations

Nanoparticles in Daily Life: Applications, Toxicity and Regulations

In vitro and in vivo toxicity assessment of nanoparticles

Safety Issue of Changed Nanotoxicity of Zinc Oxide Nanoparticles in the Multicomponent System

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