Comparative In Vitro Effect of TiF4 to NaF and Potassium Oxalate on Reduction of Dentin Hydraulic Conductance

Abstract

This study showed that titanium tetrafluoride (TiF 4 ) varnish and solution were less effective than sodium fluoride (NaF) varnish and potassium oxalate gel in reducing dentin hydraulic conductance. Therefore, TiF 4 might be not successful against dentin hypersensitivity (DH), whereas NaF varnish or potassium oxalate gel could benefit patients with DH. SUMMARYDentin hypersensitivity (DH) is related to an increase in dentin permeability. This study tested the effect of titanium tetrafluoride (TiF 4 ) compared with sodium fluoride (NaF) and potassium oxalate gel on reducing hydraulic conductance (Lp) from the perspective of diminishing dentin permeability. The Lp of the dentin disks (1.0 6 0.2 mm) was evaluated using Flodec. The maximum Lp values of each disk were taken after phosphoric acid etching (15 seconds) and randomly allocated to seven groups (n=8) according to the treatments. The minimum (smear layer) and the maximum (after acid etching) Lp values were recorded. Treatments were performed for 4 minutes as follows: 1) NaF varnish 2) and solution (2.45% F, pH 5.0), 3) TiF 4 varnish and 4) solution (2.45% F, pH 1.0), 5) 3% potassium oxalate gel, 6) free fluoride varnish (placebo, pH 5.0), 7) and no treatment (control). The Lp after each treatment was assessed. Samples were exposed to an erosive challenge (6% citric acid, pH 2.1, 1 minute), and the final Lp was recorded. The data were statistically analyzed using repeat-

Effect of Erosion/Abrasion Challenge on the Dentin Tubule Occlusion Using Different Desensitizing Agents

“…The action of a fluoride varnish is based on the reaction between NaF and calcium ions resulting in the formation of small calcium fluoride crystals (0.05 µm) deposited in the open dentinal tubules (21). A recent study (22) observed that a 5.24% sodium fluoride varnish imparted similar permeability to the minimum value before and after acid challenge, which is in line with the results of the present study. Clinical studies have reported the efficacy of fluoride varnishes in reducing dentinal hypersensitivity (23) for up to 8 weeks (24).…”

“…Potassium oxalate is considered to be an effective desensitizing agent for the reduction of dentin permeability (5,22,26,27). Studies evaluating the occlusive aspect of dentinal tubules demonstrated the penetration of potassium oxalate into the dentinal tubules and subsequent reaction with calcium ions to form calcium oxalate crystals (27,28).…”

Treatment of Dentin Hypersensitivity Using Nano-Hydroxyapatite Pastes: A Randomized Three-Month Clinical Trial

“…3,9 Accordingly, therapeutic agents that promote the occlusion of the dentin tubule apertures, such as fluoride-based agents, are interesting strategies. 10,11 Among such agents, sodium fluoride (NaF) varnish has been one of the most commonly indicated in the treatment of DH. 9,[11][12][13][14][15][16] The mechanism of action of highly concentrated fluoride (F) products is attributed to the precipitation of calcium fluoride (CaF 2 ) on the dental surface, which forms a mechanical barrier that obliterates tubule apertures, 12 potentially minimizing DH.…”

“…10,11 Among such agents, sodium fluoride (NaF) varnish has been one of the most commonly indicated in the treatment of DH. 9,[11][12][13][14][15][16] The mechanism of action of highly concentrated fluoride (F) products is attributed to the precipitation of calcium fluoride (CaF 2 ) on the dental surface, which forms a mechanical barrier that obliterates tubule apertures, 12 potentially minimizing DH. 9,13,15 Even if the effect of NaF varnish on DH relief is assumed to be limited 11,13 and descending after three and six months of application, 14 Kielbassa and others 16 found a relief effect after three weeks, which was stable for 12 months after application of a lacquer containing NaF/CaF 2 .…”

Efeito dos tratamentos dessensibilizantes na evolução de lesões erosivas na dentina

“…Para análise morfológica, este estudo utilizou a microscopia confocal a laser que permitiu avaliar o número e área dos túbulos expostos na superfície dentinária nos diferentes tempos. Para análise da permeabilidade dentinária foi utilizado o método histoquímico proposto por Pécora et al (1990) CALABRIA et al, 2014), o oxalato de potássio é eficiente para reduzir a permeabilidade da dentina devido à formação de cristais de oxalato de cálcio que precipitam e penetram ocluindo os túbulos dentinários. Atualmente, tem-se sugerido sua aplicação antes do sistema adesivo, especialmente em cavidades profundas, a fim de reduzir ou eliminar o desconforto associado com procedimentos adesivos devido à diminuição da circulação de fluidos dentro dos túbulos dentinários (DE MORAES PORTO et al, 2012;SILVA et al, 2012).…”