Comparative in vitro anthelmintic activity of three plants from the Amaranthaceae family

Kumar, Ashok; Lakshman, K.; Jayaveera, Κ. N.; Nandeesh, R.; Manoj, B.; Ranganayakulu, D.

doi:10.2298/abs1001185k

Cited by 62 publications

(37 citation statements)

References 19 publications

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“…The Anthelminthic activity [16][17][18] was carried out using adult earthworms (pheretima posthuma), belongs to the group of Annelida. 20ml of aqueous methanolic(50:50) extract of caralluma attenuata (test solutions) containing three different concentrations (100mg/ml, 200mg/ml, and 300mg/ml in distilled water) were prepared and taken in three different petridishes and 5 earthworms were placed in each petridish.…”

Section: Anthelminthic Activitymentioning

confidence: 99%

Untitled

2016

IJPSR

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Caralluma attenuata is a perennial small, leafless succulent plant which grows in tropical and subtropical areas. It belongs to the family Apocyanaceae. The folkal information reveals that the tribes generally chew the whole plant to treat peptic ulcer, diabetes, in weight reduction to suppress hunger and also to produce endurance. It has been reported for the presence of steroids, flavanoids, saponins, triterpenes and pregnane glycosides etc., several biological activities like anti-diabetic and anti ulcerogenic were reported. In the present study an attempt is made to evaluate Anti tubercular and Anthelminthic activities for aqueous methanolic (50:50) extract after carrying out the phytochemical investigations. Anti tubercular activity was evaluated by Micro plate Alamar blue assay method against streptomycin, ciprofloxacin and pyrazinamide as standard drugs. Anthelminthic activity was evaluated on Perithima posthuma using Piperazine citrate as standard drug. The results obtained for biological activities were shown to posses considerable Anti tubercular activity at 50 µg/ml and Anthelminthic activity at 300mg/ml. INTRODUCTION:Tuberculosis is the second major global infectious disease. As per WHO survey.8.7 million cases were reported in 2012 and 1.4 million people died. In low income and middle income countries over 95%of TB deaths were occurred due to malnutrition which leads to impaired immunity. It is one of important reason for prognosis of TB infection.

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Section: Anthelminthic Activitymentioning

confidence: 99%

Untitled

2016

IJPSR

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“…In a search for larvacidal activity one study found β-sitosterol (17-(5-Ethyl-6-methylheptan-2-yl)-10,13-dimethyl-2, 3,4,7,8,9,11,12,14,15,16,17 dodecahydro-1H cyclopenta [a]phenanthren-3-ol) and plumbagin. The study had utilized column chromatography and1D, 2D NMR to find out these compounds [12].…”

Section: Chemistry Of Plumbago Zeylanica Lmentioning

confidence: 99%

“…When anthelmintic drug is administered sequentially, it eliminates susceptible helminthes without affecting for parasites that are resistant. The resistant parasites in turn pass their resistant genes on to the next generation of worms [3].The majority of diseases caused by helminthes are persistent, weakening nature; and probably cause more morbidity and greater economic and social deprivation among humans and animals than any single group of parasites [4].Therefore, unless drugs especially those synthetic origin are modified or substituted by plant origin drugs with the same or higher potency, drug resistance will be unmanageable. Especially in developing countries like Ethiopia the issue is even more critical.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Anthelmintic Efficacy of Fractions from Plumbago zeylanica L (Family- Plumbaginnaceae) Root Extract

Getahun¹

2015

AJLS

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Unlike synthetic drugs plants have different phytochemical constituents which can act collectively by which helminthes cannot resist them or there could be active constituent(s) in the plant with superior potency. The aim of this study was to investigate the anthelmintic activity of both crude and fractions of Plumbago zeylanica root extract for the purpose of finding long lasting and potent medicinal plant due to significant implications of helminthes in developing countries like Ethiopia. And where traditional medicine is wide spread and of immediate alternative. In the assay, chloroform crude extracts recorded less paralysis and death time than ethanolic crude extracts. Then crude extract was subjected to column chromatography from which nine pure compounds were isolated. In addition, the isolated compounds were higher in their anthelmintic activity than crude extracts at almost all concentrations. Both crude and fractions paralyse and kill the worms with less time than that of the positive control and even less than 10 fold especially at low concentrations in case of chloroform extracts. The findings here on anthelmintic activity of the root at lower concentrations are significant and for the first time. If in vivo data are included the plant can be used as long lasting drug for helminthes.

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“…Anthelmintics from natural sources could play a key role in the treatment of these parasite infections. Hence there is an increasing demand towards natural anthelmintics (Kumar et al, 2010). Antiemetics are typically used to treat motion sickness and the side effects of opioid analgesics, general anaesthetics, and chemotherapy directed against cancer (Fake et al, 2004;Sontakke and Thawani, 2003).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical and pharmacological evaluations of Polygonum lapathifolium stem extract for anthelmintic and antiemetic activity

Bulbul¹,

Sushanta²,

Uddin³

et al. 2013

Int Curr Pharm J

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The present study is an attempt to preliminary phytochemical investigation, anthelmintic and anti-emetic activity studies on methanolic extract of Polygonum lapathifolium stems. The phytochemical screening shows the presence of phytosterols, diterpens, amino acid & protein, alkaloid and flavonoids, those are responsible for antiviral, antibacterial, antiallergic, antihypertensive, antiarrythmic, hepatoprotective, anti-inflammatory effects in mammals. In Anthelmintic activity test (using Pheretima posthuma model) five concentrations (20, 40, 60, 80 and 100 mg/ml in distilled water) of extracts were used which involved the determination of time of paralysis (vermifuge) and time of death (vermicidal activity) of the worms, where the concentration of 60, 80 &100 mg/ml showed a significant anthelmintic activity. Observations were comparable with the standard drug at concentration of 10mg/ml of piperizine citrate. On the other hand, in anti-emetic test, emesis was induced by the oral administration of copper sulphate 50mg/kg body weight to four days age of young chicks using chick emesis model. The antiemetic activity was determined by calculating the mean decrease in number of retching in contrast with those of control disorders. The extracts (150 mg /kg orally) showed statistically significant antiemetic effect (90.45% Inhibition) compared with reference drug metoclopramide (50mg/kg intraperitoneally) which showed 82.48% Inhibition. From these observations, it was concluded that stems extracts have potential anthelmintic and anti-emetic properties. The plant may further be explored for its various pharmacological activities.DOI: http://dx.doi.org/10.3329/icpj.v2i3.13582 International Current Pharmaceutical Journal, February 2013, 2(3): 57-62

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Comparative in vitro anthelmintic activity of three plants from the Amaranthaceae family

Cited by 62 publications

References 19 publications

Untitled

Untitled

In Vitro Anthelmintic Efficacy of Fractions from Plumbago zeylanica L (Family- Plumbaginnaceae) Root Extract

Phytochemical and pharmacological evaluations of Polygonum lapathifolium stem extract for anthelmintic and antiemetic activity

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