Comparative Immunohistochemical Study of the Distribution of Fibronectin in Healthy and Diseased Root Surfaces

Abstract

Changes in cementum due to periodontitis include changes in the distribution and morphology of fibronectin. These changes may influence the ability for regeneration and connective tissue attachment onto periodontally affected root surfaces.

Proteomic analysis of human dental cementum and alveolar bone

“…Because of these important roles, FN has been evaluated for use in periodontal regenerative therapies [26, 27] and bone repair processes [28, 29]. FN has been reported in bone, predentin, and dentin [22], and differentially distributed in the cementum matrix [30]. In the present investigation, FN was found at a 33-fold greater concentration in AB versus DC, perhaps suggesting a different or more critical role for FN in AB.…”

Proteomic analysis of human dental cementum and alveolar bone

“…Because of these important roles, FN has been evaluated for use in periodontal regenerative therapies [26, 27] and bone repair processes [28, 29]. FN has been reported in bone, predentin, and dentin [22], and differentially distributed in the cementum matrix [30]. In the present investigation, FN was found at a 33-fold greater concentration in AB versus DC, perhaps suggesting a different or more critical role for FN in AB.…”

Effects of conservatively treated diseased cementum with or without EMD on in vitro cementoblast differentiation and in vivo cementum‐like tissue formation of human periodontal ligament cells

“…For example, bone sialoprotein (BSP) and osteopontin, both rich in healthy cementum matrix, were found to be absent in cementum exposed to periodontal pockets . Fibronectin showed variation in its distribution and fibrillar structure in pocket cementum compared to healthy cementum . Undoubtedly, these pathological changes of diseased cementum may influence cementum regeneration and connective tissue attachment to root surfaces.…”

“…However, during the process of periodontitis, root cementum becomes exposed to periodontal pockets. In addition to contamination by bacterial plaque and endotoxin , cementum suffers loss of active substances due to periodontal inflammation . For example, bone sialoprotein (BSP) and osteopontin, both rich in healthy cementum matrix, were found to be absent in cementum exposed to periodontal pockets .…”

Evaluation of thickness of cementum of periodontally diseased teeth of non-diabetic and type 2 diabetic patients: A scanning electron microscopy study

“…Structural and compositional changes in the matrix components of cementum have been reported in patients with periodontitis. [12] Significant evidence supports a strong correlation between periodontal disease and diseased or altered cementum.…”

Proteomic analysis of human dental cementum and alveolar bone

“…Because of these important roles, FN has been evaluated for use in periodontal regenerative therapies [26, 27] and bone repair processes [28, 29]. FN has been reported in bone, predentin, and dentin [22], and differentially distributed in the cementum matrix [30]. In the present investigation, FN was found at a 33-fold greater concentration in AB versus DC, perhaps suggesting a different or more critical role for FN in AB.…”

Effects of conservatively treated diseased cementum with or without EMD on in vitro cementoblast differentiation and in vivo cementum‐like tissue formation of human periodontal ligament cells

“…For example, bone sialoprotein (BSP) and osteopontin, both rich in healthy cementum matrix, were found to be absent in cementum exposed to periodontal pockets . Fibronectin showed variation in its distribution and fibrillar structure in pocket cementum compared to healthy cementum . Undoubtedly, these pathological changes of diseased cementum may influence cementum regeneration and connective tissue attachment to root surfaces.…”

“…However, during the process of periodontitis, root cementum becomes exposed to periodontal pockets. In addition to contamination by bacterial plaque and endotoxin , cementum suffers loss of active substances due to periodontal inflammation . For example, bone sialoprotein (BSP) and osteopontin, both rich in healthy cementum matrix, were found to be absent in cementum exposed to periodontal pockets .…”

Evaluation of thickness of cementum of periodontally diseased teeth of non-diabetic and type 2 diabetic patients: A scanning electron microscopy study

“…Structural and compositional changes in the matrix components of cementum have been reported in patients with periodontitis. [12] Significant evidence supports a strong correlation between periodontal disease and diseased or altered cementum.…”

Proteomic analysis of human dental cementum and alveolar bone

“…Because of these important roles, FN has been evaluated for use in periodontal regenerative therapies [26, 27] and bone repair processes [28, 29]. FN has been reported in bone, predentin, and dentin [22], and differentially distributed in the cementum matrix [30]. In the present investigation, FN was found at a 33-fold greater concentration in AB versus DC, perhaps suggesting a different or more critical role for FN in AB.…”

Effects of conservatively treated diseased cementum with or without EMD on in vitro cementoblast differentiation and in vivo cementum‐like tissue formation of human periodontal ligament cells

“…For example, bone sialoprotein (BSP) and osteopontin, both rich in healthy cementum matrix, were found to be absent in cementum exposed to periodontal pockets . Fibronectin showed variation in its distribution and fibrillar structure in pocket cementum compared to healthy cementum . Undoubtedly, these pathological changes of diseased cementum may influence cementum regeneration and connective tissue attachment to root surfaces.…”

“…However, during the process of periodontitis, root cementum becomes exposed to periodontal pockets. In addition to contamination by bacterial plaque and endotoxin , cementum suffers loss of active substances due to periodontal inflammation . For example, bone sialoprotein (BSP) and osteopontin, both rich in healthy cementum matrix, were found to be absent in cementum exposed to periodontal pockets .…”

Evaluation of thickness of cementum of periodontally diseased teeth of non-diabetic and type 2 diabetic patients: A scanning electron microscopy study

“…Structural and compositional changes in the matrix components of cementum have been reported in patients with periodontitis. [12] Significant evidence supports a strong correlation between periodontal disease and diseased or altered cementum.…”