Comparative immunohistochemical study of ki-67, p53, caspase-3 in distal colonic polyps and colorectal adenocarcinoma.

Shyskin, M. A.

doi:10.26641/1997-9665.2019.3.149-155

Cited by 1 publication

(1 citation statement)

References 10 publications

(17 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Чимало авторів виявили, що такі операції в разі виконання повної циторедукції (R0-R1), покращують п'ятирічну виживаність до 32,0-48,0 %. Отже, віддалені результати лікування більшою мірою залежать від радикальності хірургічного втручання, а не від специфічної хімієтерапії [6].…”

unclassified

Problems of staging complicated forms of colon carcinoma in patients who were urgently operated in a general surgical hospital

Кубрак¹,

Zavhorodnii²,

Danyliuk³

2023

Patologìâ

View full text Add to dashboard Cite

The aim of the study: to analyze the results of surgical treatment and pathomorphological examination of preparations of patients who were urgently operated on for complicated forms of colon cancer, and to assess their influence on the correct staging of the tumor process in the postoperative period. Materials and methods. An analysis of data from pathomorphological studies of 71 (100 %) patients who underwent treatment at the surgical department for complicated forms of colon cancer was carried out. Results. Colon adenocarcinoma was detected in all 71 (100 %) patients (mucinous adenocarcinoma in 3 (4.23 %) patients, and the rest 68 (95.77 %) – unspecified adenocarcinoma). 44 (61.97 %) patients were diagnosed with moderately differentiated adenocarcinoma of the colon, 25 (35.21 %) – with poorly differentiated, and 2 (2.82 %) – with highly differentiated tumors. Conclusions. In the case of surgical interventions for complicated forms of colon cancer, lymphatic dissection in the minimum extent (D1) was performed in 54 (76.06 %) patients, and 17 (23.94 %) patients were operated on without removal of lymph nodes. The insufficient level of performing lymphatic dissections in patients with complicated forms of malignant pathology of the large intestine does not make it possible to assess the real picture of metastatic lesions of regional lymph nodes and to assign the correct stage of pN according to TNM 8 (in 17 (23.94 %) patients, no pathomorphological assessment was performed at all, and in 40 (56.34 %) patients, the number of examined lymph nodes were not indicated in the preparation). In the structure of staging of oncopathology, in 12 (16.90 %) patients, the stage of cancer was assign only according to the criterion of the degree of invasion (T) and in 5 (7.04 %) patients – only according to the data of instrumental examination and intraoperative revision (clinically), and was overestimated. Lack of a clear consistent assessment of the macroscopic, microscopic, immunohistochemical and molecular characteristics of the tumor process in 17 (23.94 %) patients leads to inaccuracies in the assessment of the stage of the tumor process, which in turn affects the prognosis for relapse and survival of the patient, and the tactic of postoperative treatment.

show abstract

unclassified

Problems of staging complicated forms of colon carcinoma in patients who were urgently operated in a general surgical hospital

Кубрак¹,

Zavhorodnii²,

Danyliuk³

2023

Patologìâ

View full text Add to dashboard Cite

show abstract

Comparative immunohistochemical study of ki-67, p53, caspase-3 in distal colonic polyps and colorectal adenocarcinoma.

Abstract: Comparative immunohistochemical study of ki-67, p53, caspase-3 in distal colonic polyps and colorectal adenocarcinoma.

Cited by 1 publication

References 10 publications

Problems of staging complicated forms of colon carcinoma in patients who were urgently operated in a general surgical hospital

Problems of staging complicated forms of colon carcinoma in patients who were urgently operated in a general surgical hospital

Contact Info

Product

Resources

About