Comparative immunohistochemical investigation of rat and human hepatocellular carcinomas

Thoolen, Bob; Kate, Fiebo J.W. ten; Castigliego, Domenico; Diest, Paul J. van; Malarkey, David E.; Elmore, Susan A.; Maronpot, Robert R.

doi:10.1179/2046023613y.0000000026

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Yap Accumulates In Early Preneoplastic Lesions and Oval Cells1

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2014

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“…1B). YAP staining was also observed at later stages, namely 10 weeks (a time when nodules shared histomorphological characteristic with human dysplastic nodules) [24], ( YAP cytoplasmic accumulation is associated to down-regulation of β β β β-TRCP.…”

Section: Yap Accumulates In Early Preneoplastic Lesions and Oval Cellsmentioning

confidence: 91%

YAP activation is an early event and a potential therapeutic target in liver cancer development

Perra

Kowalik

Ghiso

et al. 2014

Journal of Hepatology

192

159

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Background and Aims: Although the growth suppressor Hippo pathway has been implicated in hepatocellular carcinoma (HCC) pathogenesis, it is unknown at which stage of hepatocarcinogenesis its dysregulation occurs. We investigated in early rat and human preneoplastic lesions whether overexpression of the transcriptional co-activator Yesassociated protein (YAP) is an early event.Methods: The experimental model used is the Resistant-Hepatocyte (R-H) rat model.

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Section: Yap Accumulates In Early Preneoplastic Lesions and Oval Cellsmentioning

confidence: 91%

YAP activation is an early event and a potential therapeutic target in liver cancer development

Perra

Kowalik

Ghiso

et al. 2014

Journal of Hepatology

192

159

View full text Add to dashboard Cite

show abstract

Comparative immunohistochemical investigation of rat and human hepatocellular carcinomas

Cited by 1 publication

References 59 publications

YAP activation is an early event and a potential therapeutic target in liver cancer development

YAP activation is an early event and a potential therapeutic target in liver cancer development

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