Comparative Immunogenicity of Vaccines Prepared from Capsular Polysaccharides of Group C Neisseria meningitidis O.Acetyl.Positive and O.Acetyl.Negative Variants and Escherichia coli K92 in Adult Volunteers

Glodé, Mary P.; Lewin, Edward; Sutton, Ann; Lē, Chinh T.; Gotschlich, Emil C.; Robbins, John B.

doi:10.1093/infdis/139.1.52

Cited by 54 publications

(29 citation statements)

References 24 publications

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“…Early studies found OAcϪ MCPS to be more immunogenic than OAcϩ MCPS in adults and children (14,31) but not in infants (24). North American Vaccine Inc. (Columbia, Md.)…”

mentioning

confidence: 99%

Evaluation of De-O-Acetylated Meningococcal C Polysaccharide-Tetanus Toxoid Conjugate Vaccine in Infancy: Reactogenicity, Immunogenicity, Immunologic Priming, and Bactericidal Activity against O-Acetylated and De-O-Acetylated Serogroup C Strains

et al. 2001

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“…Early studies found OAcϪ MCPS to be more immunogenic than OAcϩ MCPS in adults and children (14,31) but not in infants (24). North American Vaccine Inc. (Columbia, Md.)…”

mentioning

confidence: 99%

Evaluation of De-O-Acetylated Meningococcal C Polysaccharide-Tetanus Toxoid Conjugate Vaccine in Infancy: Reactogenicity, Immunogenicity, Immunologic Priming, and Bactericidal Activity against O-Acetylated and De-O-Acetylated Serogroup C Strains

et al. 2001

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“…Several reports have attempted to describe the potential superiority of certain vaccine formulations over others in this regard (2,4,11,23,27,28). For example, a recent publication concluded that O-acetyl substitution is critical to the immunogenicity of serogroup A MnPS (4).…”

Section: Discussionmentioning

confidence: 99%

Analysis of Human Serum Immunoglobulin G againstO-Acetyl-Positive andO-Acetyl-Negative Serogroup W135 Meningococcal Capsular Polysaccharide

Giardina

Longworth

Evans-Johnson

et al. 2005

Clin Vaccine Immunol

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The capsular polysaccharide of Neisseria meningitidis serogroup W135 is expressed in both O-acetyl-positive (OA ؉ ) and O-acetyl-negative (OA ؊ ) forms. This study investigates the impact of OA status (OA ؉ versus OA ؊ ) on serological measurements of anti-W135 immunoglobulin G (IgG) antibodies in immunized adults. W135-specific serum antibody assignments were made for 28 postimmunization sera from adults by enzyme-linked immunosorbent assay using the meningococcal standard reference serum CDC1992. The established IgG concentration in micrograms per milliliter ([IgG]g/ml) for CDC1992 against OA ؉ antigen (16.2 g/ml) was used as a reference to assign a concentration of 10.13 g/ml IgG against OA ؊ antigen by cross-standardization. Overall, the IgG assignments for these sera were higher against OA ؉ antigen (geometric mean concentration [GMC] ‫؍‬ 7.16 g/ml) than against OA ؊ antigen (GMC ‫؍‬ 2.84 g/ml). However, seven sera showed higher specific [IgG]g/ml values against the OA ؉ antigen than against the OA ؊ antigen. These sera were also distinguished by the inability of fluid-phase OA ؊ antigen to compete for antibody binding to OA ؉ solid-phase antigen. Although there was no overall difference in functional activity measured by complement-mediated serum bactericidal assay (SBA) against OA ؉ and OA ؊ target bacteria (geometric mean titers of 9,642 and 9,045, respectively), three serum specimens showed a large difference in SBA antibody titers against OA ؉ versus OA ؊ W135 target bacteria, which may reflect different epitope specificities for these sera. Our data indicate that, for some sera, the agreement in anti-OA ؉ versus anti-OA ؊ W135 IgG assignments is serum specific and does not reflect the functional (killing) activity in vitro.

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“…The most promising work in this direction has been carried out with E. coli K92. Its capsule is a homopolymer of NeuNAc linked alternately a(2-8) and a(2-9) (128), and this structure has been used before to induce antibodies to the N. meningitidis C capsule (77 (11,54).…”

Section: Strategies To Increase Responsementioning

confidence: 99%

Current status of meningococcal group B vaccine candidates: capsular or noncapsular?

Romero

Outschoorn

1994

Clin Microbiol Rev

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Meningococcal meningitis is a severe, life-threatening infection for which no adequate vaccine exists. Current vaccines, based on the group-specific capsular polysaccharides, provide short-term protection in adults against serogroups A and C but are ineffective in infants and do not induce protection against group B strains, the predominant cause of infection in western countries, because the purified serogroup B polysaccharide fails to elicit human bactericidal antibodies. Because of the poor immunogenicity of group B capsular polysaccharide, different noncapsular antigens have been considered for inclusion in a vaccine against this serogroup: outer membrane proteins, lipooligosaccharides, iron-regulated proteins, Lip, pili, CtrA, and the immunoglobulin A proteases. Alternatively, attempts to increase the immunogenicity of the capsular polysaccharide have been made by using noncovalent complexes with outer membrane proteins, chemical modifications, and structural analogs. Here, we review the strategies employed for the development of a vaccine for Neisseria meningitidis serogroup B; the difficulties associated with the different approaches are discussed.

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Comparative Immunogenicity of Vaccines Prepared from Capsular Polysaccharides of Group C Neisseria meningitidis O.Acetyl.Positive and O.Acetyl.Negative Variants and Escherichia coli K92 in Adult Volunteers

Cited by 54 publications

References 24 publications

Evaluation of De-O-Acetylated Meningococcal C Polysaccharide-Tetanus Toxoid Conjugate Vaccine in Infancy: Reactogenicity, Immunogenicity, Immunologic Priming, and Bactericidal Activity against O-Acetylated and De-O-Acetylated Serogroup C Strains

Evaluation of De-O-Acetylated Meningococcal C Polysaccharide-Tetanus Toxoid Conjugate Vaccine in Infancy: Reactogenicity, Immunogenicity, Immunologic Priming, and Bactericidal Activity against O-Acetylated and De-O-Acetylated Serogroup C Strains

Analysis of Human Serum Immunoglobulin G againstO-Acetyl-Positive andO-Acetyl-Negative Serogroup W135 Meningococcal Capsular Polysaccharide

Current status of meningococcal group B vaccine candidates: capsular or noncapsular?

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