Comparative imaging of P, S, Fe, Cu, Zn and C in thin sections of rat brain tumor as well as control tissues by laser ablation inductively coupled plasma mass spectrometry

Zoriy, Miroslav; Dehnhardt, Markus; Matusch, Andreas; Becker, J. Sabine

doi:10.1016/j.sab.2007.11.030

Cited by 81 publications

(90 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to Jackson et al (2006), the complexity of sample preparation and instrumental techniques, the expense of instrument, and the number of analyte ions that can be determined are the important criteria for selecting a surface analytical technique. Based on literatures reported previously, besides the abovementioned fluorescence microscopic techniques, proton-induced X-ray emission (PIXE) (Thong et al, 1999;Robertson et al, 2002;Augustyniak et al, 2006;Reinert et al, 2007), microprobe synchrotron X-ray fluorescence (ASXRF) (Ide-Ektessabi, Kawakami, & Watt, 2004;Flinn et al, 2005;Serpa et al, 2008), synchrotron X-ray absorption spectroscopy (SXAS) (Collingwood et al, 2005;Mikhaylova et al, 2005), secondary ion mass spectrometry (SIMS) (Burns, 1981;Clerc, Fourre, & Fragu, 1997;Aranyosiova et al, 2008), and laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) (Feldmann, Kindness, & Ek, 2002;Becker et al, 2005aBecker et al, ,b, 2007aBecker et al, ,b, 2008aJackson et al, 2006;Dobrowolska et al, 2008;Sela et al, 2007;Zoriy et al, 2008) are the most widely applied surface analytical techniques for elemental imaging in brain tissues.…”

Section: Surface Analytical Techniquesmentioning

confidence: 99%

In vivomonitoring of the transfer kinetics of trace elements in animal brains with hyphenated inductively coupled plasma mass spectrometry techniques

Su¹,

Sun²,

Tzeng³

et al. 2009

Mass Spectrom. Rev.

View full text Add to dashboard Cite

The roles of metal ions to sustain normal function and to cause dysfunction of neurological systems have been confirmed by various studies. However, because of the lack of adequate analytical method to monitor the transfer kinetics of metal ions in the brain of a living animal, research on the physiopathological roles of metal ions in the CNS remains in its early stages and more analytical efforts are still needed. To explicitly model the possible links between metal ions and physiopathological alterations, it is essential to develop in vivo monitoring techniques that can bridge the gap between metalloneurochemistry and neurophysiopathology. Although inductively coupled plasma mass spectrometry (ICP-MS) is a very powerful technique for multiple trace element analyses, when dealing with chemically complex microdialysis samples, the detection capability is largely limited by instrumental sensitivity, selectivity, and contamination that arise from the experimental procedure. As a result, in recent years several high efficient and clean on-line sample pretreatment systems have been developed and combined with microdialysis and ICP-MS for the continuous and in vivo determination of the concentration-time profiles of metal ions in the extracellular space of rat brain. This article reviews the research relevant to the development of analytical techniques for the in vivo determination of dynamic variation in the concentration levels of metal ions in a living animal.

show abstract

Section: Surface Analytical Techniquesmentioning

confidence: 99%

In vivomonitoring of the transfer kinetics of trace elements in animal brains with hyphenated inductively coupled plasma mass spectrometry techniques

Su¹,

Sun²,

Tzeng³

et al. 2009

Mass Spectrom. Rev.

View full text Add to dashboard Cite

show abstract

“…Maps can then be constructed of both metals and non-metals essential to physiology. Recently, elemental bioimaging has been applied to human glioblastomas 16 , labelled β-amyloid-bound antibodies in Alzheimer's disease 17 , implanted tumour cells 18 and Cu, Zn and Pt in cis-platin dosed mice 19 .…”

Section: Introductionmentioning

confidence: 99%

Elemental bio-imaging of melanoma in lymph node biopsies

Hare

Burger

Austin

et al. 2009

Analyst

View full text Add to dashboard Cite

The spatial distribution of trace elements in human lymph nodes partially infiltrated by melanoma cells was determined by elemental bio-imaging. Imaging of 31 P within the nodal capsule and normal lymph node tissue showed a clear demarcation of the tumour boundary, with a significant decrease in relative 31 P concentration within the tumour. The location of the tumour boundary was confirmed by haematoxylin and eosin staining of serial sections and observation by light microscopy. Further enhancement of the tumour boundary was achieved by imaging the 31 P/ 34 S ratio. 31 P/ 66 Zn ratio images showed a decreasing ratio beyond the tumour boundary that extended into peritumour normal lymph node tissue.

show abstract

“…IMS techniques allow the distribution of elements and isotopes to be ascertained mainly by LA-ICP-MS [32][33][34]. This powerful analytical technique possesses superior features not only for quantitative elemental imaging analysis, but also for isotopic ratio measurements to produce images of detailed regionally specific element distributions in thin tissue sections of different sizes [33,[35][36][37][38]. LA-ICP-MS with multielement capability was employed for the bioimaging of a multitude of metals as well as of selected nonmetals (C, Cl, I, P, S, Se) at trace concentration level in tissue sections of animal and plant tissues [34,[39][40][41][42][43].…”

Section: Analytical Approachesmentioning

confidence: 99%

Bioimaging of Metals and Proteomic Studies of Clinical Samples by Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA‐ICP‐MS)

Becker

Becker²

2012

Analytical Techniques for Clinical Chemistry

View full text Add to dashboard Cite

Comparative imaging of P, S, Fe, Cu, Zn and C in thin sections of rat brain tumor as well as control tissues by laser ablation inductively coupled plasma mass spectrometry

Cited by 81 publications

References 29 publications

In vivomonitoring of the transfer kinetics of trace elements in animal brains with hyphenated inductively coupled plasma mass spectrometry techniques

In vivomonitoring of the transfer kinetics of trace elements in animal brains with hyphenated inductively coupled plasma mass spectrometry techniques

Elemental bio-imaging of melanoma in lymph node biopsies

Bioimaging of Metals and Proteomic Studies of Clinical Samples by Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA‐ICP‐MS)

Contact Info

Product

Resources

About