Comparative Histology and Vibration of the Vocal Folds: Implications for Experimental Studies in Microlaryngeal Surgery

Garrett, C. Gaelyn; Coleman, John R.; Reinisch, Lou

doi:10.1097/00005537-200005000-00011

Cited by 107 publications

(122 citation statements)

References 11 publications

(15 reference statements)

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“…Based on our experience with pig models, the dimensions of the larynx in a 30 to 40 kg pig are similar to that of the adult human (Garrett, Coleman et al 2000;Jiang, Raviv et al 2001). The vocal folds have a similar configuration, and the intrinsic muscles and distribution of the recurrent laryngeal nerve is similar as demonstrated by detailed dissections of cadaveric porcine laryngeal neuromuscular anatomy (Knight, McDonald et al 2005).…”

Section: Porcine Modelsmentioning

confidence: 96%

“…Various animal models have been used extensively in vocal fold studies with their results compared across models (Garrett, Coleman et al 2000;Jiang, Raviv et al 2001;Titze and Alipour 2006;Alipour and Jaiswal 2007;Alipour and Jaiswal 2008;Bless and Welham 2010;Alipour, Jaiswal et al 2011). Three of the more commonly used models in operative studies are rabbits (Thibeault, Gray et al 2002;Thibeault, Bless et al 2003;Branski, Rosen et al 2005;Carneiro and Scapini 2009;Campagnolo, Tsuji et al 2010), dogs (Garrett, Coleman et al 2000;Fleming, McGuff et al 2001;Rousseau, Hirano et al 2003;Karajanagi, Lopez-Guerra et al 2011) and pigs (Blakeslee, Banks et al 1995;Garrett, Coleman et al 2000;Jiang, Raviv et al 2001;Alipour and Jaiswal 2008;Fonseca, Malafaia et al 2010).…”

Section: Selection Of Animal Modelsmentioning

confidence: 99%

“…Three of the more commonly used models in operative studies are rabbits (Thibeault, Gray et al 2002;Thibeault, Bless et al 2003;Branski, Rosen et al 2005;Carneiro and Scapini 2009;Campagnolo, Tsuji et al 2010), dogs (Garrett, Coleman et al 2000;Fleming, McGuff et al 2001;Rousseau, Hirano et al 2003;Karajanagi, Lopez-Guerra et al 2011) and pigs (Blakeslee, Banks et al 1995;Garrett, Coleman et al 2000;Jiang, Raviv et al 2001;Alipour and Jaiswal 2008;Fonseca, Malafaia et al 2010). …”

Section: Selection Of Animal Modelsmentioning

confidence: 99%

“…Comparing vocal fold structure across dogs, monkeys, pigs and human models using histology and laryngeal videostroboscopy, Garrett et al (Garrett, Coleman et al 2000) found that unlike the human vocal fold, which has a higher elastin concentration in the deeper layers of the lamina propria, both pig and dog had a thin band of elastin concentrated just deep to the epithelial basement membrane zone. Just deep to this thin band, collagen and the elastin were less concentrated as in humans.…”

Section: Canine Modelsmentioning

confidence: 99%

“…The arytenoid cartilages have been described as fused across the posterior commissure, making laryngoscopic exposure more difficult (Garrett, Coleman et al 2000). In addition to this, the arytenoids are also positioned more superiorly resulting in a steeper angle to the vocal folds.…”

Section: Porcine Modelsmentioning

confidence: 99%

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Probing vocal fold fibroblast response to hyaluronan in 3D contexts

Muñoz-Pinto

Jimenez-Vergara

Gelves

et al. 2009

Biotech & Bioengineering

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A number of treatments are being investigated for vocal fold (VF) scar, including designer implants. The aim of the present study was to validate a 3D model system for probing the effects of various bioactive moieties on VF fibroblast (VFF) behavior toward rational implant design. We selected poly(ethylene glycol) diacrylate (PEGDA) hydrogels as our base-scaffold due to their broadly tunable material properties. However, since cells encapsulated in PEGDA hydrogels are generally forced to take on rounded/stellate morphologies, validation of PEGDA gels as a 3D VFF model system required that the present work directly parallel previous studies involving more permissive scaffolds. We therefore chose to focus on hyaluronan (HA), a polysaccharide that has been a particular focus of the VF community. Toward this end, porcine VFFs were encapsulated in PEGDA hydrogels containing consistent levels of high Mw HA (HA(HMW)), intermediate Mw HA (HA(IMW)), or the control polysaccharide, alginate, and cultured for 7 and 21 days. HA(HMW) promoted sustained increases in active ERK1/2 relative to HA(IMW). Furthermore, VFFs in HA(IMW) gels displayed a more myofibroblast-like phenotype, higher elastin production, and greater protein kinase C (PkC) levels at day 21 than VFFs in HA(HMW) and alginate gels. The present results are in agreement with a previous 3D study of VFF responses to HA(IMW) relative to alginate in collagen-based scaffolds permissive of cell elongation, indicating that PEGDA hydrogels may serve as an effective 3D model system for probing at least certain aspects of VFF behavior.

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Utility of serum tumor markers, imaging, and biliary cytology for detecting cholangiocarcinoma in primary sclerosing cholangitis

Charatcharoenwitthaya

et al. 2008

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There is limited information on test performance for detecting cholangiocarcinoma in primary sclerosing cholangitis (PSC), particularly when used sequentially. This study aimed to characterize diagnostic performance of serum carbohydrate antigen 19-9 (CA 19-9), ultrasonography, computed tomography, magnetic resonance imaging, cholangiography, and biliary cytologic techniques for detecting cholangiocarcinoma in PSC. All consecutive patients with PSC were screened and followed for development of cholangiocarcinoma from 2000 through 2006. Of 230 patients, 23 developed cytopathologically confirmed cholangiocarcinoma with an annual incidence of 1.2%. The optimal cutoff value for serum CA 19-9 was 20 U/mL, which yielded a sensitivity of 78%, specificity of 67%, positive predictive value (PPV) of 23%, and negative predictive value (NPV) of 96%. Serum CA 19-9 combined with either ultrasonography, computed tomography, or magnetic resonance imaging provided a sensitivity of 91%, 100%, and 96%, specificity of 62%, 38%, and 37%, PPV of 23%, 22%, and 24%, and NPV of 98%, 100%, and 98%, respectively, if at least one method was positive. Subsequent cholangiographic examinations in these patients increased specificity to 69% and PPV to 42% while maintaining sensitivity of 91% and NPV of 96%. Following this group, conventional cytology, aneuploidy detection by digital imaging analysis, and aneusomy detection by fluorescence in situ hybridization in brushing samples of biliary strictures had a sensitivity of 50%, 57%, and 86%, specificity of 97%, 94%, and 83%, PPV of 86%, 89%, and 80%, and NPV of 83%, 74%, and 88%, respectively, for detecting cholangiocarcinoma. Conclusion: Tumor serology combined with cross-sectional liver imaging may be useful as a screening strategy and cholangiography with cytologic examination is helpful for the diagnosis of cholangiocarcinoma in patients with PSC. C holangiocarcinoma occurs with increased frequency in patients with primary sclerosing cholangitis (PSC) and is currently a leading cause of death in these patients. [1][2][3][4] The development of cholangiocarcinoma is unpredictable on the basis of the duration, symptoms, and severity of PSC. 2,4 The cholangiographic appearance of benign strictures of PSC makes the diagnosis of cholangiocarcinoma difficult in this setting. Most patients are diagnosed with advanced unresectable disease, which imparts a dismal prognosis and is a contraindication of liver transplantation. 3 However, innovative approaches using a combination of neoadjuvant chemoradiotherapy and liver transplantation provide excellent outcomes with 5-year survival of 82% in Abbreviations: AUC, area under the curve; CT, computed tomography; DIA, digital From the

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Comparative Histology and Vibration of the Vocal Folds: Implications for Experimental Studies in Microlaryngeal Surgery

Cited by 107 publications

References 11 publications

Investigation of Experimental Wound Closure Techniques in Voice Microsurgery

Investigation of Experimental Wound Closure Techniques in Voice Microsurgery

Probing vocal fold fibroblast response to hyaluronan in 3D contexts

Utility of serum tumor markers, imaging, and biliary cytology for detecting cholangiocarcinoma in primary sclerosing cholangitis

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