Comparative heel stick study showed that newborn infants who had undergone repeated painful procedures showed increased short‐term pain responses

Gokulu, Gamze; Bilgen, Hülya; Özdemir, Hülya; Sarioz, Abdullah; Memişoğlu, Aslı; Gücüyener, Kıvılcım; Özek, Eren

doi:10.1111/apa.13557

Cited by 28 publications

(20 citation statements)

References 31 publications

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“… 12 – 14 In some situations, behavioral observation-based scales could be limited to measurements of the subcortical somatic and autonomic motor pathways; consequently, they were not suitable for diagnosing the pain experience with accuracy in neonates. 13 , 15 …”

Section: Introductionmentioning

confidence: 99%

Multimodal pain assessment: are near-infrared spectroscopy, skin conductance, salivary cortisol, physiologic parameters, and Neonatal Facial Coding System interrelated during venepuncture in healthy, term neonates?

Roué¹,

Rioualen²,

Gendras³

et al. 2018

JPR

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BackgroundImproving pain and stress assessments in neonates remains important in preventing the short- and long-term consequences. We aimed to identify the relationships between different pain assessment parameters by simultaneously measuring changes in cortical, autonomic, hormonal, physiological, and behavioral evoked responses to venepuncture in healthy, full-term neonates.MethodsThis observational, prospective study (ancillary to the ACTISUCROSE trial) included 113 healthy, 3-day old, full-term neonates who underwent venepuncture for systematic neonatal screening, from July to October 2013, in a tertiary-level maternity ward of a university hospital. During venepuncture, we simultaneously measured the cortical single-channel near-infrared spectroscopy (NIRS) signals, foot skin conductance, salivary cortisol, physiological responses, and behavioral (Neonatal Facial Coding System [NFCS]) evoked responses.ResultsRegarding the NIRS analysis, the highest correlation was between the NFCS at venepuncture and the change in NIRS integrated values of total hemoglobin (r=0.41, P<0.001) or oxygenated hemoglobin (r=0.27, P<0.001). The NFCS at venepuncture was moderately positively correlated with changes in salivary cortisol (r=0.42, P<0.001) and skin conductance (r=0.29, P<0.001). Salivary cortisol and skin conductance changes were not correlated; the latter parameters were not correlated with heart rate, respiratory rate, or SpO2.ConclusionDuring venepuncture, NFCS was mildly or moderately correlated with salivary cortisol, skin conductance, and cortical NIRS changes.

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Section: Introductionmentioning

confidence: 99%

Multimodal pain assessment: are near-infrared spectroscopy, skin conductance, salivary cortisol, physiologic parameters, and Neonatal Facial Coding System interrelated during venepuncture in healthy, term neonates?

Roué¹,

Rioualen²,

Gendras³

et al. 2018

JPR

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“…All this data was in favour of overall alteration of central and autonomic nervous system development secondary to preterm birth. In contrast, changes in pain reactivity have already been described in infants subjected to a stay in the NICU or in those experiencing a greater frequency of painful challenges in the neonatal period regardless of the birth term (8,24). These data were in favour of a conditioning hypothesis resulting from inappropriate stimuli during postnatal care, independently of prematurity.…”

Section: Discussionmentioning

confidence: 95%

“…In parallel, peripheral sympathetic activity leads to cutaneous acetylcholine withdrawal measured by the skin conductance signal. Skin conductance has been revealed as a potential tool for measuring stress and painful responses to various stimuli in the neonatal population .…”

Section: Introductionmentioning

confidence: 99%

Prematurity alters skin conductance and behavioural scoring after acute stress in term‐equivalent age infants

et al. 2019

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Aim The primary objective was to assess the effect of prematurity at term‐equivalent age on skin conductance and behavioural responses to acute stress. The secondary objective was to explore the reliability of skin conductance in detecting neonatal discomfort in preterm and full‐term populations. Methods Very preterm infants at term‐equivalent age and healthy full‐term neonates, 34 infants in each group, underwent the hip dysplasia screening test. The acute pain in newborn infants (APN) scale was scored before and 15, 45 and 90 seconds after stimulus. Skin conductance was measured in the 30‐second time‐lap before and after stimulus. Results The APN score was lower in preterm infants after intervention (term: 5.4 ± 2.8 vs. preterm: 3.9 ± 2.2; p = 0.03). Peaks‐per‐second, a skin conductance parameter, exhibited lower basal values in preterm infants than in term infants, with similar rise induced by stressful challenge. Peaks‐per‐second values were correlated to the 15‐second APN score in both groups (term: r = 0.55, p < 0.001; preterm: r = 0.43, p = 0.01). Conclusion Preterm birth changed skin conductance signal and behavioural response to stress at term‐equivalent age. The skin conductance device may be an objective tool for a continuous monitoring of acute neonatal stress.

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“…(20) preterm bebeklerde ardı ardına yapılan üç topuk delme işleminde, kalp tepe atım değerlerinin arttığını, üçüncü topuk delme işleminde ilk iki işleme göre kalp tepe atımı değerlerindeki artış yüzdesinin daha fazla olduğunu tespit etmişlerdir. Son yıllarda tekrarlayan ağrının serebral oksijenizasyon üzerine etkisi ve deri iletkenliği ile ilgili çalışmalar yapılmaya başlanmıştır (21,22) . Halen tekrarlayan ağrının, uzun döneme yansıyan olumsuz etkilerini ortaya koyan çalışmaların sınırlı olduğu görülmektedir.…”

Section: Discussionunclassified

The Effect of Kangaroo Care on Pain Score During Repeated Heel Lance in Newborns

Yücel¹,

Sarı²,

Olukman³

2020

BUCH

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Bu araştırmanın amacı, tekrarlayan topuk kanı alma sırasında uygulanan kanguru bakımının yenidoğanın ağrı puanına etkisini incelemektir. Yöntem: Araştırma randomize kontrollü yarı deneysel çalışma türündedir. Araştırmaya orta riskli hiperbilirubinemi tanısıyla yatmış, miadında doğan, yaşamlarının iki-yedinci günlerinde olan, 30 girişim, 30 kontrol olmak üzere toplam 60 yenidoğan dahil edilmiştir. Araştırmanın yürütüldüğü ünitede oral alımında sorun olmayan tüm yenidoğanlara işlemden iki dk. önce %25'lik sukroz çözeltisi bir-iki ml ağızdan verilmektedir. Kontrol grubundaki yenidoğanların her ağrılı girişiminde klinik rutini uygulanmıştır. Girişim grubundaki yenidoğanlara ise son ağrılı girişim öncesinde 30 dk.'lık kanguru bakımı verilmiş, işlemden hemen önce klinikte rutin olarak kullanılan %25'lik oral sukroz çözeltisi verilmiştir. Araştırmacı tarafından uygun teknikle topuk kanı alınmış, işlem anında ve işlemden iki dk. sonra iki bağımsız gözlemci tarafından NIPS ölçeği ile ağrı puanı değerlendirilmiştir. Bulgular: Birinci topuk kanı alma işleminde girişim ve kontrol grubundaki yenidoğanların ağrı puan ortalamaları arasında fark saptanmamıştır. İkinci kan alma işlemi sırasında kanguru bakımı verilen yenidoğanların ağrı puan ortalamasının (3,13±2,33) kontrol grubundaki yenidoğanlara (6,10±0,96) göre anlamlı şekilde düşük olduğu saptanmıştır (p<0,001). İkinci kan alma işlemi sonrasında ağrı puan ortalamasının kanguru bakımı verilen yenidoğanlarda 0,33±1,18, kontrol grubundaki yenidoğanlarda 1,07±2,20 olduğu, gruplar arasındaki farkın anlamlı olmadığı belirlenmiştir (p>0,05). Sonuç: Sonuç olarak, tekrarlayan ağrılı girişimlerde kanguru bakımının işlem sırasında ağrı puanını düşürdüğü saptanmıştır.

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Comparative heel stick study showed that newborn infants who had undergone repeated painful procedures showed increased short‐term pain responses

Abstract: Babies who received more painful stimuli during the first few days of life showed greater pain responses during a subsequent heel prick.

Cited by 28 publications

References 31 publications

Multimodal pain assessment: are near-infrared spectroscopy, skin conductance, salivary cortisol, physiologic parameters, and Neonatal Facial Coding System interrelated during venepuncture in healthy, term neonates?

Multimodal pain assessment: are near-infrared spectroscopy, skin conductance, salivary cortisol, physiologic parameters, and Neonatal Facial Coding System interrelated during venepuncture in healthy, term neonates?

Prematurity alters skin conductance and behavioural scoring after acute stress in term‐equivalent age infants

The Effect of Kangaroo Care on Pain Score During Repeated Heel Lance in Newborns

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