Comparative genomics on BMP4 orthologs

Katoh, Yuriko; Katoh, Masaru

doi:10.3892/ijo.27.2.581

Cited by 14 publications

(22 citation statements)

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“…18 BMB4 is preferentially expressed in diffuse type gastric cancer. 55,56 Although previous report ruling out the implication of SHH signaling pathway in signet-ring cell carcinoma might be due to sampling bias, activation of FGF7/FGFR2 and BMP4 signaling pathways might contribute to downregulation of SHH signaling in signet-ring cell carcinoma.…”

Section: A B Shh Signaling In Gastric Mucosa and Gastric Cancermentioning

confidence: 99%

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Hedgehog signaling pathway and gastric cancer

Katoh¹,

Katoh²

2005

Cancer Biology & Therapy

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149

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Section: A B Shh Signaling In Gastric Mucosa and Gastric Cancermentioning

confidence: 99%

“…56 Gastric fundic glands consist of stem cells, surface epithelial cells, mucous neck cells, parietal cells, chief cells, and enterochromaffin cells. Stem cells are located at the isthmus around the middle of the vertical tubular unit.…”

Section: A B Shh Signaling In Gastric Mucosa and Gastric Cancermentioning

confidence: 99%

Hedgehog signaling pathway and gastric cancer

Katoh¹,

Katoh²

2005

Cancer Biology & Therapy

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149

131

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“…WNT, Notch, FGF, Hedgehog, and BMP signaling pathways network together during embryogenesis, tissue regeneration, and carcinogenesis (1)(2)(3)(4)(5)(6)(7)(8). Canonical WNT signals are transduced through Frizzled receptors and LRP5/6 co-receptors to activate transcription of target genes, such as FGF18, FGF20, DKK1 and DKK4, based on the transcriptional complex consisting of TCF/LEF, ß-catenin, BCL9/BCL9L, and PYGO1/ PYGO2 (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

Comparative integromics on BMP/GDF family

Katoh¹,

Katoh²

2006

Int J Mol Med

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Abstract. WNT, Notch, FGF, Hedgehog and BMP signaling pathways network together during embryogenesis, tissue regeneration, and carcinogenesis. BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMP10, BMP15, AMH, GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, GDF8, GDF9, GDF10, GDF11, and GDF15 are BMP/GDF family genes within the human genome; however, transcriptional regulation of BMP/GDF family members by the canonical WNT signaling pathway remains unclear. We searched for the TCF/LEF-binding site within the promoter region of BMP/GDF family genes by using bioinformatics and human intelligence. Because four TCF/LEF-binding sites were identified within human GDF10 promoter, comparative genomics analyses on GDF10 orthologs were further performed. Chimpanzee GDF10 gene, encoding a 477-amino-acid protein, was identified within NW_112875.1 genome sequence. AY412135.1 was not the correct coding sequence for chimpanzee GDF10. Chimpanzee GDF10 showed 99.2%, 83.2% and 47.4% total amino-acid identity with human GDF10, mouse Gdf10 and human BMP3, respectively. RASGEF1A-GDF10-PRKG1 locus at human chromosome 10q11 and BMP3-PRKG2-RASGEF1B locus at human chromosome 4q21 were paralogous regions with insertions/deletions and recombination. Human GDF10 mRNA was expressed in fetal cochlea, fetal lung, testis, retina, pineal gland, other neural tissues, head and neck tumors, while mouse Gdf10 mRNA was expressed in fetal liver, inner ear, cerebellum, other neural tissues, prostate and blood vessels. Four TCF/LEF-binding sites in human GDF10 promoter were conserved in chimpanzee GDF10 promoter, but not in the mouse Gdf10 promoter; however, another TCF/LEF-binding site occurred in mouse Gdf10 promoter. Four bHLH-binding sites in human GDF10 promoter were conserved in chimpanzee GDF10 promoter, but only one in mouse Gdf10 promoter. Primate GDF10 promoters were divergent from mouse Gdf10 promoter. Because GDF10 was characterized as a potential target of canonical WNT signaling pathway in neural tissues, GDF10 is one of the targets of systems medicine, especially in the field of regenerative medicine.

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“…Two transcripts (gbx2 [37], c-myc [38]) were downregulated. Gbx2 is within the wnt pathway and not a known myc target gene ( [39]; http://www.myccancergene.org/index.asp). Overall, these results suggest that pluripotent stem cell populations have the capacity to respond to ROS while retaining their major self-renewal signatures.…”

Section: Maintenance Of Stem Cell Markersmentioning

confidence: 99%

Transcriptional and Phospho-Proteomic Screens Reveal Stem Cell Activation of Insulin-Resistance and Transformation Pathways Following a Single Minimally Toxic Episode of Ros

Mouzannar

McCafferty²,

Benedetto³

et al. 2011

Int J Genom Proteomics

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Abstract-Elevated reactive oxidative species (ROS) are cytotoxic, and chronic elevated levels of ROS have been implicated in multiple diseases as well as cellular transformation and tumor progression. However, the potential for a transient and minimally toxic episode of ROS exposure, or a minimal threshold dose of ROS, to initiate disease or cellular transformation is unclear. We examined both transcriptional and phospho-proteomic responses of murine embryonic stem (ES) cells to a single brief exposure of minimally toxic hydrogen peroxide (H2O2). The cellular response was distinct from those induced by either an acute exposure to H2O2 or the topoisomerase II poison etoposide. Analysis of tumorigenesis-related transcripts revealed a significant up-regulation of oncogenes and down-regulation of tumor suppressors. Analysis of the phospho-proteomic response demonstrated insulinsignaling induction, including insulin receptor Y972 hypophosphorylation, similar to insulin-resistance mouse models and observed in diabetic patients. In addition, ES cells were more resistant to ROS than differentiated cells, and retained their transcriptional self-renewal signature, suggesting stem cells have a higher potential for ROS-mediated mutagenesis and proliferation in vivo. These results are a direct demonstration that even brief and non-toxic exposures to ROS may induce transduction of insulin resistance and transformation signaling in stem cells leading to diabetes and cancer.

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Comparative genomics on BMP4 orthologs

Cited by 14 publications

References 0 publications

Hedgehog signaling pathway and gastric cancer

Hedgehog signaling pathway and gastric cancer

Comparative integromics on BMP/GDF family

Transcriptional and Phospho-Proteomic Screens Reveal Stem Cell Activation of Insulin-Resistance and Transformation Pathways Following a Single Minimally Toxic Episode of Ros

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