Comparative genomics of nematodes

Mitreva, Makedonka; Blaxter, Mark; Bird, David; McCarter, James P.

doi:10.1016/j.tig.2005.08.003

Cited by 138 publications

(100 citation statements)

References 79 publications

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“…In D. immitis, 55% of the most abundant (Table 1) and 75% of the most conserved (Supplementary Tables 1) transcripts have C. elegans homologs with detected phenotypes when silenced in RNAi experiments. Compared with the roughly 22% possibility of observing RNAi phenotypes in C. elegans at its whole genome level (reviewed by Mitreva et al, 2005), we confirmed the correlation between presence of the RNAi phenotypes and sequence conservation (and possibly levels of expression) as noticed in several other parasitic nematodes previously (McCarter et al, 2003;Mitreva et al, 2004a).…”

Section: Functional Categorization and Other Sequence Analysissupporting

confidence: 89%

Identification and analysis of genes expressed in the adult filarial parasitic nematode Dirofilaria immitis

Yin

Martin

McCarter

et al. 2006

International Journal for Parasitology

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The heartworm Dirofilaria immitis is a filarial parasitic nematode infecting dogs and other mammals worldwide causing fatal complications. Here, we present the first large-scale survey of the adult heartworm transcriptome by generation and analysis of 4005 expressed sequence tags, identifying about 1800 genes and expanding the available sequence information for the parasite significantly. Brugia malayi genomic data offered the most valuable information to interpret heartworm genes, with about 70% of D. immitis genes showing significant similarities to the assembly. Comparative genomic analyses revealed both genes common to metazoans or nematodes and genes specific to filarial parasites that may relate to parasitism. Characterization of abundant transcripts suggested important roles for genes involved in energy generation and antioxidant defense in adults. In particular, we proposed that adult heartworm likely adopted an anaerobic electron transfer-based energy generation system distinct from the aerobic pathway utilized by its mammalian host, making it a promising target in developing next generation macrofilaricides and other treatments. Our survey provided novel insights into the D. immitis transcriptome and laid a foundation for further comparative studies on biology, parasitism and evolution within the phylum Nematoda. q

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Section: Functional Categorization and Other Sequence Analysissupporting

confidence: 89%

Identification and analysis of genes expressed in the adult filarial parasitic nematode Dirofilaria immitis

Yin

Martin

McCarter

et al. 2006

International Journal for Parasitology

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“…Insects and nematodes share a common ancestor as members of the high-level taxon Ecdysozoa (Aguinaldo et al 1997) and both induce cellular modifications in host tissues, including the formation of galls, implying a role for phytohormones (Bird and Koltai 2000). Progress in the sequencing of nematode genomes has revolutionised the understanding of these organisms at the molecular level (Mitreva et al 2005) and can also help in understanding the aquisition of CK mechanisms by eukaryotes in general. It was shown that besides intrachromosomal rearrangements and modifications to secretory proteins, some parasitic nematodes might rely on virulence factors acquired by HGT from prokaryotes (Mitreva et al 2005).…”

Section: Evolution and Use Of Cks By Plant-interacting Organisms As Tmentioning

confidence: 99%

“…Progress in the sequencing of nematode genomes has revolutionised the understanding of these organisms at the molecular level (Mitreva et al 2005) and can also help in understanding the aquisition of CK mechanisms by eukaryotes in general. It was shown that besides intrachromosomal rearrangements and modifications to secretory proteins, some parasitic nematodes might rely on virulence factors acquired by HGT from prokaryotes (Mitreva et al 2005). HGT thus represents an important route of evolution from free-living nematodes to the parasitic lifestyle (Mitreva et al 2005).…”

Section: Evolution and Use Of Cks By Plant-interacting Organisms As Tmentioning

confidence: 99%

Cytokinins - recent news and views of evolutionally old molecules

Spíchal¹

2012

Functional Plant Biol.

156

171

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Cytokinins (CKs) are evolutionally old and highly conserved low-mass molecules that have been identified in almost all known organisms. In plants, they evolved into an important group of plant hormones controlling many physiological and developmental processes throughout the whole lifespan of the plant. CKs and their functions are, however, not unique to plants. In this review, the strategies and mechanisms of plants – and phylogenetically distinct plant-interacting organisms such as bacteria, fungi, nematodes and insects employing CKs or regulation of CK status in plants – are described and put into their evolutionary context. The major breakthroughs made in the last decade in the fields of CK biosynthesis, degradation and signalling are also summarised.

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“…Helmentler oldukça karmaşık canlılar-dır (21) . Bu gün için helmentlerin kendilerini tedavi edici olarak kullanmak yerine helmentlerden elde edilecek farklı moleküler yapıların kullanı-labileceği yönünde görüşler de vardır (9) .…”

Section: Etik Tartışmaunclassified

Usage of Parasites as Alternative Therapy

Yereli¹

2012

Ankem Derg

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Comparative genomics of nematodes

Cited by 138 publications

References 79 publications

Identification and analysis of genes expressed in the adult filarial parasitic nematode Dirofilaria immitis

Identification and analysis of genes expressed in the adult filarial parasitic nematode Dirofilaria immitis

Cytokinins - recent news and views of evolutionally old molecules

Usage of Parasites as Alternative Therapy

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