Comparative genomics of Leishmania isolates from Brazil confirms the presence of Leishmania major in the Americas

Almeida, Laila Viana de; Reis-Cunha, João Luís; Coqueiro-dos-Santos, Anderson; Rodrigues-Luís, Gabriela Flávia; Baptista, Rodrigo P.; Silva, Soraia de Oliveira; Melo, Maria Norma; Bartholomeu, Daniella Castanheira

doi:10.1016/j.ijpara.2021.05.009

Cited by 7 publications

(4 citation statements)

References 64 publications

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“… 10 In the Mediterranean, the competence of the mosquito Anopheles sergentii as a vector was verified, 11 raising the hypothesis of the feasibility of introducing this disease into other European countries. In Brazil, where PCR is not a routinely performed test, there are potential vectors for L. major 12 , 13 and isolated cases of L. majo r- like strains, possibly L. major , 14 have been described in the Midwest in the 1970s and 1980s, in patients with no history of travelling. 15 However, there is lack of information to evaluate the capacity for autochthonous transmission.…”

Section: Discussionmentioning

confidence: 99%

Fourth case of tegumentary leishmaniasis in Brazil by Leishmania major ‒ is it possible for new species to be introduced in Brazil through immigration?

Matsumoto

Enokihara

Ogawa

et al. 2023

Anais Brasileiros de Dermatologia

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Section: Discussionmentioning

confidence: 99%

Fourth case of tegumentary leishmaniasis in Brazil by Leishmania major ‒ is it possible for new species to be introduced in Brazil through immigration?

Matsumoto

Enokihara

Ogawa

et al. 2023

Anais Brasileiros de Dermatologia

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“…Below are a few recent examples of how TriTrypDB data and tools have been utilized by the research community to conduct their own research. TriTrypDB genomes and annotations have been used to characterize individual genes [69][70][71][72][73] or gene families [74,75], identify orthologs across species [55,70,76], conduct genome-wide analyses to study genetic variations such as SNPs, CNVs and hybridization events [77][78][79], perform comparative genomic [80][81][82] and phylogenetic/ phylogenomic [82,83] analyses, and as reference genomes for the assembly and/or annotation of newly generated genomes [16,84]. Similarly, the genome assemblies and annotations have also been utilized for the analysis of differential gene expression [19,72,85], protein expression [85][86][87], the identification of post-translational modifications [72] and potential new genes missing in the official gene sets [88].…”

Section: Recent Science Enabled By Tritrypdbmentioning

confidence: 99%

TriTrypDB: An integrated functional genomics resource for kinetoplastida

et al. 2023

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Parasitic diseases caused by kinetoplastid parasites are a burden to public health throughout tropical and subtropical regions of the world. TriTrypDB (https://tritrypdb.org) is a free online resource for data mining of genomic and functional data from these kinetoplastid parasites and is part of the VEuPathDB Bioinformatics Resource Center (https://veupathdb.org). As of release 59, TriTrypDB hosts 83 kinetoplastid genomes, nine of which, including Trypanosoma brucei brucei TREU927, Trypanosoma cruzi CL Brener and Leishmania major Friedlin, undergo manual curation by integrating information from scientific publications, high-throughput assays and user submitted comments. TriTrypDB also integrates transcriptomic, proteomic, epigenomic, population-level and isolate data, functional information from genome-wide RNAi knock-down and fluorescent tagging, and results from automated bioinformatics analysis pipelines. TriTrypDB offers a user-friendly web interface embedded with a genome browser, search strategy system and bioinformatics tools to support custom in silico experiments that leverage integrated data. A Galaxy workspace enables users to analyze their private data (e.g., RNA-sequencing, variant calling, etc.) and explore their results privately in the context of publicly available information in the database. The recent addition of an annotation platform based on Apollo enables users to provide both functional and structural changes that will appear as ‘community annotations’ immediately and, pending curatorial review, will be integrated into the official genome annotation.

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“…Leishmaniasis, in turn, is a group of diseases caused by protozoans from the genus Leishmania , divided into skin and systemic manifestations. Species such as L. braziliensis , L. amazonensis , L. major , and L. tropica mostly cause tegumentary leishmaniasis, including cutaneous and mucosal manifestations of leishmaniasis, while L. infantum and L. donovani are causative agents of visceral leishmaniasis [ 15 , 16 , 17 , 18 , 19 , 20 , 21 ]. Additionally, cases of post-kala-azar dermal leishmaniasis, a cutaneous manifestation, are reported after visceral leishmaniasis by L. donovani [ 15 , 16 ].…”

Section: Often Forgotten Never Gone: Neglected Tropical Diseasesmentioning

confidence: 99%

Schistosoma and Leishmania: An Untold Story of Coinfection

et al. 2023

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A remarkable characteristic of infectious diseases classified as Neglected Tropical Diseases (NTDs) is the fact that they are mostly transmitted in tropical and subtropical regions with poor conditions of sanitation and low access to healthcare, which makes transmission areas more likely to overlap. Two of the most important NTDs, schistosomiasis and leishmaniasis, despite being caused by very different etiological agents, have their pathogenesis heavily associated with immune-mediated mechanisms, and Schistosoma spp. and Leishmania spp. have been shown to simultaneously infect humans. Still, the consequences of Schistosoma–Leishmania coinfections remain underexplored. As the inflammatory processes elicited by each one of these parasites can influence the other, several changes have been observed due to this coinfection in naturally infected humans, experimental models, and in vitro cell assays, including modifications in susceptibility to infection, pathogenesis, prognostic, and response to treatment. Herein, we review the current knowledge in Schistosoma–Leishmania coinfections in both human populations and experimental models, with special regard to how schistosomiasis affects tegumentary leishmaniasis, discuss future perspectives, and suggest a few steps to further improve our understanding in this model of parasite–host–parasite interaction.

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Comparative genomics of Leishmania isolates from Brazil confirms the presence of Leishmania major in the Americas

Cited by 7 publications

References 64 publications

Fourth case of tegumentary leishmaniasis in Brazil by Leishmania major ‒ is it possible for new species to be introduced in Brazil through immigration?

Fourth case of tegumentary leishmaniasis in Brazil by Leishmania major ‒ is it possible for new species to be introduced in Brazil through immigration?

TriTrypDB: An integrated functional genomics resource for kinetoplastida

Schistosoma and Leishmania: An Untold Story of Coinfection

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