Comparative Genomics of
            <i>Salmonella</i>
            <i>enterica</i>
            Serovar Typhi Strains Ty2 and CT18

Deng, Wen-Ling; Liou, Shian-Ren; Plunkett, Guy; Mayhew, George F.; Rose, Debra J.; Burland, Valerie; Kodoyianni, Voula; Schwartz, David C.; Blattner, Frederick R.

doi:10.1128/jb.185.7.2330-2337.2003

Cited by 320 publications

(285 citation statements)

References 38 publications

Supporting

Mentioning

271

Contrasting

Unclassified

Order By: Relevance

“…Comparison of Typhi Tp2 with the two genome sequence strains CT18 (Parkhill et al, 2001) and Ty2 (Deng et al, 2003) revealed that Tp2 was identical to Ty2 in all four genes sequenced, but differed from CT18 by one base in torC. While most SARB strains have functionally intact sequences, four cases of gene inactivation were observed.…”

Section: Sequence Variation In the Four Genesmentioning

confidence: 99%

Frequent recombination and low level of clonality within Salmonella enterica subspecies I

Octavia

Lan

2006

Microbiology

View full text Add to dashboard Cite

The genetic relationship and population structure of Salmonella enterica subspecies I strains were analysed using nucleotide sequences of four genes (mglA, proV, torC and speC). Fifteen strains from the Salmonella reference collection B (SARB), belonging to 13 serovars, were analysed. Sequence data of two housekeeping genes, mdh and mutS, of the same 15 strains reported by Brown et al. (2003) (Proc Natl Acad Sci U S A 100, 15676-15681) were also included in the analyses. Phylogenetic analysis revealed that there was a lack of congruence among the six gene trees. Split decomposition analysis resolved only five strains with a network structure, while others showed a star phylogeny. Compatibility values for the SARB strains were the lowest in comparison to those for strains representing different subspecies of S. enterica. These results showed that the genes studied have undergone frequent recombination, suggesting a low level of clonality within subspecies I of S. enterica.

show abstract

Section: Sequence Variation In the Four Genesmentioning

confidence: 99%

Frequent recombination and low level of clonality within Salmonella enterica subspecies I

Octavia

Lan

2006

Microbiology

View full text Add to dashboard Cite

show abstract

“…CP000705. A similar exercise was performed for Listeria innocua Clip11262 (Glaser et al, 2001) and Salmonella enterica Typhi Ty2 (Deng et al, 2003), for which we compared the G+C content and codon usage of their vitamin B 12 clusters to their published genomes.…”

Section: Methodsmentioning

confidence: 99%

The complete coenzyme B12 biosynthesis gene cluster of Lactobacillus reuteri CRL1098

et al. 2008

View full text Add to dashboard Cite

“…the murine yersiniosis model). The full genome sequences of strains belonging to Y. pestis biovars Orientalis and Medievalis have been completed (Parkhill et al, 2001;Deng et al, 2002) All of the human-pathogenic yersiniae possess plasmid pYV and most of the pathogenicity studies on yersiniae have largely focused on determinants found on this plasmid, which encodes the type III secretion system essential for virulence. Y. pestis possesses two additional plasmids (pMT1 and pPCP1) which also encode key virulence determinants.…”

Section: Introductionmentioning

confidence: 99%

A Caenorhabditis elegans model of Yersinia infection: biofilm formation on a biotic surface

et al. 2003

View full text Add to dashboard Cite

To investigate Yersinia pathogenicity and the evolutionary divergence of the genus, the effect of pathogenic yersiniae on the model organism Caenorhabditis elegans was studied. Three strains of Yersinia pestis, including a strain lacking pMT1, caused blockage and death of C. elegans; one strain, lacking the haemin storage (hms) locus, caused no effect. Similarly, 15 strains of Yersinia enterocolitica caused no effect. Strains of Yersinia pseudotuberculosis showed different levels of pathogenicity. The majority of strains (76 %) caused no discernible effect; 5 % caused a weak infection, 9?5 % an intermediate infection, and 9?5 % a severe infection. There was no consistent relationship between serotype and severity of infection; nor was there any relationship between strains causing infection of C. elegans and those able to form a biofilm on an abiotic surface. Electron microscope and cytochemical examination of infected worms indicated that the infection phenotype is a result of biofilm formation on the head of the worm. Seven transposon mutants of Y. pseudotuberculosis strain YPIII pIB1 were completely or partially attenuated; mutated genes included genes encoding proteins involved in haemin storage and lipopolysaccharide biosynthesis. A screen of 15 defined C. elegans mutants identified four where mutation caused (complete) resistance to infection by Y. pseudotuberculosis YPIII pIB1. These mutants, srf-2, srf-3, srf-5 and the dauer pathway gene daf-1, also exhibit altered binding of lectins to the nematode surface. This suggests that biofilm formation on a biotic surface is an interactive process involving both bacterial and invertebrate control mechanisms.

show abstract

Comparative Genomics of Salmonella enterica Serovar Typhi Strains Ty2 and CT18

Cited by 320 publications

References 38 publications

Frequent recombination and low level of clonality within Salmonella enterica subspecies I

Frequent recombination and low level of clonality within Salmonella enterica subspecies I

The complete coenzyme B12 biosynthesis gene cluster of Lactobacillus reuteri CRL1098

A Caenorhabditis elegans model of Yersinia infection: biofilm formation on a biotic surface

Contact Info

Product

Resources

About