Comparative genomics of a subset of Adherent/Invasive Escherichia coli strains isolated from individuals without inflammatory bowel disease

Barrios-Villa, Edwin; Peña, Claudia F. Martínez de la; Lozano-Zaraín, Patricia; Cevallos, Miguel A.; Torres, Carmén; Torres, Alfredo G.; Rocha-Gracia, Rosa del Carmen

doi:10.1016/j.ygeno.2019.10.013

Cited by 19 publications

(15 citation statements)

References 52 publications

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“…Afa/Dr adhesins include Dr, DrII, AfaE/I–III, AfaE-V, NFA-I, and F1845 adhesins. Afa, Dr, and F1845 adhesins are encoded by afaA-E , DraA-E , and daaA-E genes, respectively [ 107 , 114 ]. F1845 and Dr adhesins bind to the decay-accelerating factor (DAF), a molecule expressed and found on the apical surface of urinary and intestinal epithelial cells, inducing cytoskeleton rearrangement and destroying microvilli [ 11 , 32 , 88 ].…”

Section: Diffusely Adherent Escherichia Coli (Daec)mentioning

confidence: 99%

“…Higher levels of expression of genes encoding virulence factors involved in adhesion, invasion, and survival encoding were detected in AIEC isolated from patients with CD, IBD, and ulcerative colitis [ 128 , 129 , 130 ]. Virulence factors present in AIEC isolated from patients with intestinal disorders include the adhesive subunit of type-1 fimbriae, the polypeptide stress response protein, the invasion protein ibeA , the invasion plasmid antigen, and virulence factors involved in ferric yersiniabactin uptake and capsule synthesis encoded by fimH , yjaA , ibeA , ipaH , fyuA , and kpsMT II genes, respectively [ 114 , 131 , 132 ]. AIEC strains have been considered a new therapeutic target for treating patients with IBD and CD [ 123 ].…”

Section: Adherent Invasive Escherichia Coli (Aiec)mentioning

confidence: 99%

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Virulence Factors of Enteric Pathogenic Escherichia coli: A Review

Pakbin

Brück²,

Rossen

2021

IJMS

136

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Escherichia coli are remarkably versatile microorganisms and important members of the normal intestinal microbiota of humans and animals. This harmless commensal organism can acquire a mixture of comprehensive mobile genetic elements that contain genes encoding virulence factors, becoming an emerging human pathogen capable of causing a broad spectrum of intestinal and extraintestinal diseases. Nine definite enteric E. coli pathotypes have been well characterized, causing diseases ranging from various gastrointestinal disorders to urinary tract infections. These pathotypes employ many virulence factors and effectors subverting the functions of host cells to mediate their virulence and pathogenesis. This review summarizes new developments in our understanding of diverse virulence factors associated with encoding genes used by different pathotypes of enteric pathogenic E. coli to cause intestinal and extraintestinal diseases in humans.

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Section: Diffusely Adherent Escherichia Coli (Daec)mentioning

confidence: 99%

Section: Adherent Invasive Escherichia Coli (Aiec)mentioning

confidence: 99%

Virulence Factors of Enteric Pathogenic Escherichia coli: A Review

Pakbin

Brück²,

Rossen

2021

IJMS

136

View full text Add to dashboard Cite

show abstract

“…Afa/Dr adhesins include Dr, DrII, AfaE/I-III, AfaE-V, NFA-I and F1845 adhesins. Afa, Dr and F1845 adhesins are encoded by afaA-E, DraA-E and daaA-E genes, respectively [107,114]. F1845 and Dr adhesins bind to decay-accelerating factor (DAF), a molecule expressed and found on the apical surface of urinary and intestinal epithelial cells, inducing cytoskeleton rearrangement and destroying microvilli [11,32,88].…”

Section: Enteroaggregative Escherichia Coli (Eaec)mentioning

confidence: 99%

“…Higher levels of expression of genes encoding virulence factors involved in adhesion, invasion, and survival encoding were detected in AIEC isolated from patients with CD, IBD, and ulcerative colitis [128][129][130]. Virulence factors present in AIEC isolated from patients with intestinal disorders include adhesive subunit of type 1 fimbriae, the polypeptide stress response protein, the invasion protein ibeA, the invasion plasmid antigen, and virulence factors involved in ferric yersiniabactin uptake and capsule synthesis encoded by fimH, yjaA, ibeA, ipaH, fyuA and kpsMT II genes, respectively [114,131,132]. AIEC strains have been considered a new therapeutic target for treating patients with IBD and CD [123].…”

Section: Adherent Invasive Escherichia Coli (Aiec)mentioning

confidence: 99%

Virulence factors of Enteric Pathogenic Escherichia coli: A Review

Pakbin¹,

Brück²,

Rossen³

2021

Preprint

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Escherichia coli are remarkably versatile microorganisms and important members of the normal intestinal microbiota of humans and animals. This harmless commensal organism can acquire a mixture of comprehensive mobile genetic elements that contain genes encoding viru-lence factors, becoming an emerging human pathogen capable of causing a broad spectrum of intestinal and extraintestinal diseases. Nine definite enteric E. coli pathotypes have been well characterized, causing diseases ranging from various gastrointestinal disorders to urinary tract infections. These pathotypes employ many virulence factors and effectors subverting the func-tions of host cells to mediate its virulence and pathogenesis. This review summarizes new de-velopments in our understanding of diverse virulence factors associated encoding genes used by different pathotypes of enteric pathogenic E. coli to cause intestinal and extraintestinal diseases in humans.

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“…The most distinguishing genes of the isolates recovered from the eggs produced by free-range production system from the isolates recovered from the eggs produced by barn and cage systems include DNA translocase FtsK, L-aspartate oxidase, Macrolide export ATP-binding/permease protein MacB, exodeoxyribonuclease 8, and lysozyme RrrD. These genes were identified to be associated with translocating genes, regulating gene expression, cell wall division and formation, sugar metabolism, and phosphorylation in bacteria (36)(37)(38)(39)(40)(41)(42). This demonstrates that the Salmonella isolated from eggs source from barn and cage production systems have undergone different mutations that have somehow altered their genomic compositions.…”

Section: Production System Leads To Genetic Variationsmentioning

confidence: 99%

Whole-Genome Comparative Analysis Reveals Association Between Salmonella Genomic Variation and Egg Production Systems

et al. 2021

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Non-typhoidal Salmonella, particularly Salmonella enterica serovar Typhimurium (S. Typhimurium), is the predominant endemic serovar in the Australian egg production industry and is one of the most frequently reported serovars in foodborne infections in Australia. This study was conducted to investigate the genomic characteristics of Salmonella isolated from retail table eggs in Western Australia and to identify the impact of production systems on genomic characteristics of Salmonella such as virulence and antimicrobial resistance. A total of 40 non-typhoidal Salmonella isolates [S. Typhimurium isolates (n = 28) and Salmonella Infantis isolates (n = 12)] sourced from retail eggs produced by different production systems (barn-laid, cage, and free-range) in Western Australia were sequenced by whole-genome sequencing. The isolates were de novo assembled, annotated, and analyzed. The results indicated an association between Salmonella genomic variation and the system used to raise poultry for egg production (p-value < 0.05). All but one of the S. Infantis isolates were recovered from eggs collected from poultry raised under barn and cage production systems. A higher proportion (83.3%) of S. Typhimurium isolates were recovered from the eggs produced by free-range production system as compared with those produced under barn (76.9%) and cage production systems (53.3%). Our analysis indicated that Salmonella isolated from the eggs produced by barn and cage production systems had more virulence genes than the isolates of the free-range produced eggs. A low carriage of antimicrobial-resistant gene was detected in the isolates of this study. We have built a Salmonella genomics database and characteristics-linked gene pools to facilitate future study, characterization, and tracing of Salmonella outbreaks.

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Comparative genomics of a subset of Adherent/Invasive Escherichia coli strains isolated from individuals without inflammatory bowel disease

Cited by 19 publications

References 52 publications

Virulence Factors of Enteric Pathogenic Escherichia coli: A Review

Virulence Factors of Enteric Pathogenic Escherichia coli: A Review

Virulence factors of Enteric Pathogenic Escherichia coli: A Review

Whole-Genome Comparative Analysis Reveals Association Between Salmonella Genomic Variation and Egg Production Systems

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