Comparative Genomic Characterization of Multidrug-resistant Citrobacter Spp. Strains in Fennec Fox Imported to China

Qin, Jie; Xu, Hao; Zhao, Yi; Wang, Aifang; Chi, Xiaohui; Wen, Peipei; Li, Shuang; Wu, Lingjiao; Bi, Sheng

doi:10.21203/rs.3.rs-539805/v1

Cited by 2 publications

(2 citation statements)

References 31 publications

(41 reference statements)

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“…can act as a reservoir of AMR and CR genes with the ability to disseminate them to other species. Citrobacter species have been observed carrying MGEs containing genes imparting resistance to aminoglycosides, tetracyclines (TETs), and trimethoprim (Qin et al, 2021). Furthermore, prominent carbapenemase genes, including KPC, NDM, and OXA-48, have been detected alongside other AMR genes within MGEs found in species of Citrobacter (Yao et al, 2021).…”

Section: Carbapenemase-producing Enterobacteriaceaementioning

confidence: 99%

Dissemination of carbapenemase‐producing Enterobacteriaceae and associated resistance determinants through global food systems

Harding-Crooks

Smith

Fanning

et al. 2023

Comp Rev Food Sci Food Safe

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Antimicrobial agents are a critical component of modern healthcare systems, fulfilling a core function in patient care and improving individual patient outcomes and consequently overall public health. However, the efficacy of antimicrobial interventions is being consistently eroded by the emergence and dissemination of various antimicrobial resistance (AMR) mechanisms. One highly valued class of antimicrobial compounds is carbapenems, which retain efficacy in treating most multidrug‐resistant infections and are considered “last line” agents. Therefore, recent trends in proliferation of carbapenem resistance (CR) via dissemination of carbapenemase‐encoding genes among members of the Enterobacteriaceae family pose a significant threat to public health. While much of the focus relating to this has been on nosocomial environments, community‐acquired carbapenemase‐producing Enterobacteriaceae (CPE) infections and their associated transmission routes are less well studied. Among these community‐associated vectors, the role of food chains and contaminated foods is important, since Enterobacteriaceae occupy niches within these settings. This review examines foodborne CPE transmission by exploring how interactions within and between food, the food chain, and agriculture not only promote and disseminate CPE, but also create reservoirs of mobile genetic elements that may lead to further carbapenemase gene proliferation both within and between microbial communities. Additionally, recent developments regarding the global occurrence and molecular epidemiology of CPEs in food chains will be reviewed.

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Section: Carbapenemase-producing Enterobacteriaceaementioning

confidence: 99%

Dissemination of carbapenemase‐producing Enterobacteriaceae and associated resistance determinants through global food systems

Harding-Crooks

Smith

Fanning

et al. 2023

Comp Rev Food Sci Food Safe

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“…Citrobacter spp. bears genetic adjacency to E. coli (Qin et al 2021). The antibiotic-resistant coliforms serve as a cenote for the antibiotic resistance gene.…”

Section: Similarity Matrix Of the Coliformsmentioning

confidence: 99%

Antimicrobial Resistance in Escherichia coli and other Coliform Bacteria Isolated from Bagmati River

Ghimire,

Pokhrel,

Banjara

et al. 2023

TU J. Microbiol.

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Objectives: To explore the presence of fecal indicator bacteria and assess antibiotic resistance status in Bagmati river water. Methods: In a cross sectional study during a year 2020; a total of 180 water samples were collected from the Bagmati River’s upstream, midstream, and downstream sources. Maintaining reverse cold chain, the samples were transferred to the laboratory of central department of Microbiology, Tribhuvan University. Organisms were isolated on Eosin Methylene Blue (EMB) and Nutrient Agar. The organisms were further identified based on the biochemical properties and antibiotic susceptibility testing was performed following CLSI (2020) guidelines. Results: Of the 546 isolates, 209 (or 38%) were Escherichia coli. Other coliforms isolated were Enterobacter spp (2%), Citrobacter spp (37%), and Klebsiella spp (23%). Upstream source revealed least percentage 3% (7/209) of E. coli. All the recovered Citrobacter spp. were resistant and E. coli showed >99% resistance towards Tetracycline, Ampicillin and Amoxiclav antibiotics. Klebsiella spp. was 100% resistant towards Ampicillin and Amoxiclav antibiotics. The coliforms exhibited least resistance (10%) towards Chloramphenicol. Based on antibiotic resistance percentage pattern, E. coli showed 27% similarity to Citrobacter spp. Conclusion: Coliforms showed maximum resistance towards first line antibiotics prescribed in human infection. Immediate water safety plans should be instituted to improve the water quality.

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Comparative Genomic Characterization of Multidrug-resistant Citrobacter Spp. Strains in Fennec Fox Imported to China

Cited by 2 publications

References 31 publications

Dissemination of carbapenemase‐producing Enterobacteriaceae and associated resistance determinants through global food systems

Dissemination of carbapenemase‐producing Enterobacteriaceae and associated resistance determinants through global food systems

Antimicrobial Resistance in Escherichia coli and other Coliform Bacteria Isolated from Bagmati River

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