Comparative genome annotation for mapping, prediction and discovery of genes

Genome Sequence Analysis: A Survey

“…A high level abstraction is used at alignment of sequences with the introduction of prolog tool, which some times is not quite useful for generating standard optimal results and overall comparison is not quite visible [1] . Kappen [2] described an annotated technique for comparisons between a mouse chromosome 9 and a human chromosome 15, the data draft sequences had been obtained from genetic databases and a complex map containing 14 genes has been presented as a genome map, the framework described in the study for data interpretation and demonstration can be quite helpful for generation of more complex maps provided time constrained is kept in mind, the ideas may lead towards implementation of automated genome annotation techniques [2] . A very useful feature of this approach was to use information for human and mouse species comparatively and to describe a frame work for the discovery of three previously unknown genes.…”

“…A very useful feature of this approach was to use information for human and mouse species comparatively and to describe a frame work for the discovery of three previously unknown genes. The limitation of this framework requires more labor in the form of critical evaluation before accepting any kind of predictions and focus must be made on smaller region in the map to bring more sophisticated results [2] . Nahar [3] presented a web based tool that provides comparative genome sequence analysis, this tool is interactive and user of the program can interact with different parts to view/monitor better results.…”