Comparative Genetic Characterization of CTX-M-Producing Escherichia coli Isolated from Humans and Pigs with Diarrhea in Korea Using Next-Generation Sequencing

Seo, Kwang-Won; Do, Kyung-Hyo; Lee, Wan-Kyu

doi:10.3390/microorganisms11081922

Cited by 2 publications

(2 citation statements)

References 37 publications

(48 reference statements)

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“…Group 1 CTX-M variants are the most widespread globally compared to other variants and in Africa and Asia, reports indicated that CTX-M group 1 are more common [ 10 , 15 ]. Of the CTX-M Group 1, CTX-M-15 is currently the dominant variant and a cause of concern in clinical practice [ 16 ]. The literature suggests that the CTX-M-15 gene variants are widely distributed in countries in Europe, North and South America as well as Asia [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Epidemiology of Cefotaxime-Hydrolysing β-Lactamase-Producing Escherichia coli in Children with Diarrhoea Reported Globally between 2012 and 2022

Karambwe,

Traoré,

Potgieter

2024

Microorganisms

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The global spread of cefotaxime-hydrolysing β-lactamase (CTX-M)-producing Escherichia coli (E. coli) and its associated impact on paediatric diarrhoeal treatment and management has become a public health concern. This review assessed surveillance studies on CTX-M-producing E. coli associated with diarrhoea in children published between 2012 and 2022 globally. A total of thirty-eight studies were included for data analysis, categorised into continental regions, and tabulated. The majority (68%) of studies were conducted in Asian countries while few studies were conducted in Europe (11%) and Africa (18%), respectively. On the African continent, the majority (11%) of studies were conducted in Northern Africa while no studies were reported in East Africa. On the American continent, 3% of the studies were reported from South America. The studies included were classified into diarrheagenic E. coli (74%; 28/38) and faecal carriage (26%; 10/38). Of all the E. coli pathotypes associated with CTX-M production, EPEC was frequently reported. The prevalence of CTX-M-producing E. coli including the CTX-M-15-producing variants ranged between 1% and 94%. About 37% of the studies generalised the report as blaCTX-M-positive E. coli. The use of sequencing in characterising the CTX-M-producing E. coli was reported in only 32% of all the studies. This review provides information on the epidemiology of CTX-M-15-producing E. coli in paediatric diarrhoea and the extent to which surveillance is being performed. This is relevant in informing clinical practice for the management of diarrhoea as well as the design of future surveillance studies.

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Section: Introductionmentioning

confidence: 99%

“…Information regarding specific E. coli pathotypes associated with CTX-M genes is scarce [ 19 ]. While CTX-M are the predominant ESBL genes encountered, two other genes, namely TEM, and SHV, which encode enzymes that confer beta-lactam resistance are also encountered in the Enterobacteriaceae group such as E. coli [ 16 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Cefotaxime-Hydrolysing β-Lactamase-Producing Escherichia coli in Children with Diarrhoea Reported Globally between 2012 and 2022

Karambwe,

Traoré,

Potgieter

2024

Microorganisms

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Progress toward alleviating preventable waterborne diseases over the past 30 years

Ford,

Hamner

2023

Camb. prisms Water

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Over the past several decades, there have been a number of national and international meetings on waterborne diseases. Conclusions from these meetings often seem remarkably similar and suggest little progress in the field of water and health. This is both a true and a false premise, as our ability to use molecular tools to describe microbial communities has advanced to the level at which whole genome sequencing is now a routine practice and can even be deployed in the field. This article seeks to illustrate both these advances and their limitations, especially for use in low-resourced settings. What remains clear is that for most of the world, basic hygiene and sanitation measures can do more for human health than any of our current advances in molecular biology. That is not to say that these advances are not remarkable and that they can undoubtedly revolutionize risk-based testing and surveillance. Although there are many factors that contribute to increased risks from waterborne diseases, climate change above all else is creating challenges that we are ill-prepared to meet. The biggest barrier to control of these diseases is not limitations in technology but has been and continues to be the lack of political will and economic incentives.

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Comparative Genetic Characterization of CTX-M-Producing Escherichia coli Isolated from Humans and Pigs with Diarrhea in Korea Using Next-Generation Sequencing

Cited by 2 publications

References 37 publications

Epidemiology of Cefotaxime-Hydrolysing β-Lactamase-Producing Escherichia coli in Children with Diarrhoea Reported Globally between 2012 and 2022

Epidemiology of Cefotaxime-Hydrolysing β-Lactamase-Producing Escherichia coli in Children with Diarrhoea Reported Globally between 2012 and 2022

Progress toward alleviating preventable waterborne diseases over the past 30 years

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