Comparative frequencies of anti-IgA antigodies among patients with anaphylactic transfusion reactions and among normal blood donors

Rivat, L; Rivat, C.; Daveau, Maryvonne; Ropartz, C

doi:10.1016/0090-1229(77)90068-x

Cited by 38 publications

(14 citation statements)

References 18 publications

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“…Class-specific anti-IgA or anti-IgA allotypes (A2ml) have been clearly demonstrated to be responsible for immediate hypersensitivity reactions. How ever, the role played by the anti-immuno globulin antibodies of so-called 'limited spe cificity' still remains unclear [6][7][8][9]17]. We have previously reported similar results in is also probable that, in immunodeficient patients, circulating bacterial antigens may be involved in such adverse reactions [10].…”

supporting

confidence: 70%

Human IgE Response to the Administration of Blood Components

Ropars¹,

Geay-Chicot²,

Cartron³

et al. 1979

Vox Sanguinis

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43 adults from a renal dialysis unit staff have received regularly spaced γ-globulin administrations for hepatitis B prophylaxis. Several blood samples were collected over a prolonged period of time (160 days). Following γ-globulin administration, anti-immunoglobulin antibodies of the IgE class were detected in 80% of this population, a fortnight after the first injection using serum absorptions on polymerized γ-globulins or a specific inverse RAST method. The reactivity pattern of these IgE anti-immunoglobulin antibodies was similar to that observed for the anti-immunoglobulin antibodies with ‘limited specificity’ detected by passive hemagglutination, in that they reacted with only one of the immunoglobulins of the panel used for their detection. A decrease of the overall IgE levels was observed in 62% of the subjects for a prolonged period of time following γ-globulin administration. This suggests a feedback regulation mechanism for the reagin production in man, as it has already been observed in animals. A high incidence of anti-immunoglobulin antibodies of various classes was observed in this study. However, only a small number (4/43) of adverse reactions appeared following γ-globulin administration. For some of these subjects, the presence of specific IgE anti-immunoglobulin, detected by the inverse-RAST technique, suggests a possible role of such antibodies in some intolerance reactions to γ-globulin administration.

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supporting

confidence: 70%

Human IgE Response to the Administration of Blood Components

Ropars¹,

Geay-Chicot²,

Cartron³

et al. 1979

Vox Sanguinis

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“…The incidence of anti-IgA antibodies among nonIgA-deficient individuals, 4.0% (14 of 350), is not out of keeping with previous reports using a passive he magglutination technique (0.4-41%) [15,25] or a radioimmunoassay (2.0-7.9%) [26]. The reason for the higher frequency of anti-IgA antibodies among the non-IgA-deficient blood donors than among the nonIgA-deficient patients is not clear.…”

Section: Discussionmentioning

confidence: 42%

IgG Anti-IgA1 and Anti-IgA2 Antibodies: Their Measurement by an Enzyme-Linked Immunosorbent Assay and Their Relationship to Disease

Petty¹,

Sherry²,

Johannson³

1986

Int Arch Allergy Immunol

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IgG anti-IgA antibodies were measured by an enzyme-linked immunosorbent assay using one IgA1 and one IgA2 (ml) myeloma and a pooled IgA protein preparation as antigens. Class-specific anti-IgA antibodies occurred in 0.8% of non-IgA-deficient sera and 24.3% of IgA-deficient sera. Antibodies reacting with IgA1 only occurred in 2.6% of non-IgA-deficient sera and 6.7% of IgA-deficient sera. Antibodies reacting with IgA2 only occurred in 0.6% of non-IgA-deficient sera and 2.7% of IgA-deficient sera. The prevalence of anti-IgA in IgA deficients with inflammatory disease was higher (81.8%) than in IgA deficients without disease (24.1 %) and was accounted for by class-specific antibodies.

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“…Although previous literatures documented 0.5---6% seropositivity in healthy individuals, 20,24 which could be increased to 59% if the threshold was considered, more or less suggesting anti-IgA as a natural antibody. 30 In contrast, reduction of the natural antibodies such as iso-haemagglutinin, heterophilic, antierythrocytic, and antibacterial was proved in patients with PAD. 31---33 Therefore, XLA and HIgM patients, with a class switched antibody production defect, comparing to the healthy individuals, failed to show anti-IgA antibody.…”

Section: Discussionmentioning

confidence: 94%