Comparative Fluoride Release and Antimicrobial Analysis of Commercial and Experimental Bioactive Glass/Nano-Oxide-Based Dentifrices

Abstract

Objectives The objectives were to measure fluoride release and assess the antimicrobial behavior of fluoride-doped nano bioactive glass (F-nBG) and nano zinc oxide (ZnO)-enriched novel dentifrices. Materials and Methods Experimental dentifrices were synthesized by incorporating ZnO nanoparticles and F-nBG (1.5 wt% and 4 wt%) as active ingredients. The fluoride release behavior of suspensions and elutes of samples were analyzed by ion selective electrode. Antimicrobial activity and minimum bactericidal concentration against Streptococcus mutans and Lactobacillus casei were evaluated. Microbial stability against contamination was also assessed by a challenge test. Results The fluoride release behavior of experimental dentifrices was higher than that of commercial dentifrices and was dependent on filler loading. The fluoride release was more from suspensions than elutes. Zones of inhibition (ZOIs) and minimum bactericidal concentration values for novel dentifrices showed direct proportionality with filler loading, and effectiveness was exhibited against both strains. Experimental dentifrices exhibited effective antibacterial potential, which could possibly be due to release of sufficient fluoride and zinc ions in aqueous media from F-nBG and ZnO present in their formulations. Conclusion Combination of F-nBG and ZnO may provide a multi-benefit approach for simultaneously treating early white spot lesions, reducing bacterial growth, and providing core plaque control.

Zinc- and Fluoride-Releasing Bioactive Glass as a Novel Bone Substitute

“…In addition, F incorporation into phosphate-based glass could inhibit the growth of periodontal pathogens, such as Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis (Liu et al 2016). Compared with F-doped silica-based glass alone, the combination of F-doped silica-based glass and ZnO can effectively reduce S. mutans growth (Gul et al 2020). We demonstrated that Zn- and F-releasing phosphate-based glasses exerted robust antimicrobial effects against S. mutans , one of the main biofilm-forming bacterial species in the oral cavity (Fig.…”

Recent Development of Active Ingredients in Mouthwashes and Toothpastes for Periodontal Diseases

“…Furthermore, fluoride release was found to be more efficient from suspensions than from elutes of the samples of the dentifrice. This is suggested to be of great clinical significance since dentifrices are used in the suspension form during brushing [ 160 ].…”