Comparative expression of syndecan‐1 and Ki‐67 in peripheral and desmoplastic ameloblastomas and ameloblastic carcinoma

Abstract

The aims of the present study were to examine whether the pattern of syndecan-1 expression correlates with cellular proliferation index in desmoplastic ameloblastomas (DA), peripheral ameloblastomas (PA) and ameloblastic carcinomas (AC), and to compare with that previously reported for solid (SA) and unicystic (UA) variants of ameloblastoma. Immunohistochemistry was performed for syndecan-1 and Ki-67 in seven ameloblastomas (four DA and three PA) and three AC. Expression of syndecan-1 was related to the histological subtype of tumors and, in the case of malignancy, to lower expression levels observed in AC (22.5%) than in PA (47.5%) or DA (77.5%) (P < 0.05). Syndecan-1 expression correlated inversely with Ki-67 proliferative index: the expression was lower in both types of ameloblastomas (1.5% in DA and 6.4% in PA) than in AC (41.2%; P < 0.05). The present results suggest that the decrease in syndecan-1 expression and increase in the Ki-67 index observed in AC is in accordance with its higher aggressiveness as compared to the rare DA and PA. Interestingly, DA had a lower proliferation index as well as the highest levels of syndecan-1 expression. These data suggest that DA differ from the other types of intraosseous ameloblastomas but more studies are necessary to better understand the role of this protein as a marker in the biological behavior of the epithelial odontogenic neoplasms.

The Diagnostic Usefulness of Immunohistochemistry for Odontogenic Lesions

“…Overall, however, all ameloblastomas have been shown to have a very low proliferative index (Fig. 1f, reviewed in Gomes et al [17]), and it is possible that proliferation markers may be useful to help diagnose malignant ameloblastomas, especially in small biopsies [18]. However, this issue requires further exploration to determine its clinical usefulness.…”

Peripheral Desmoplastic Ameloblastoma: Histopathological and Immunohistochemical profile of a case

“…Immunohistochemical expression of CK5 in basal/suprabasal cells and CK14 in suprabasal/central cells in the present case offer evidence of maturation of the epithelial component; low index of p53 protein and Ki-67 expression in epithelium and stromal cells of PDA, as well as CD138 uniform positive-stain in epithelial cells, support the benign biological behavior of the lesion, as has been reported previously in their intraosseus counterpart. (13) High expression of syndecan-1 in DA could be associated with a better cell-cell and cell-extracellular matrix adhesion in epithelial ameloblastic zones (islands), suggesting a less aggressive and invasive behavior and could explain, to some degree, the unique clinicopathological features of this slow growing lesion, which in turn, may favor the presence of desmoplasia (14).…”

Peripheral Ameloblastoma with Dystrophic Calcification: An Unusual Feature in Non-Calcifying Odontogenic Tumors

“…Several studies have demonstrated that peripheral ameloblastomas may present indolent behavior compared with the central variant (10,22,23). Thus, the treatment of choice is a conservative supraperiosteal excision with adequate disease-free margins (1,4).…”