Comparative Expression of E-cadherin, .ALPHA. and .BETA. Catenin in Salivary Gland Tumors.

Yamada, Kazuto; Namba, Miyako; Kudeken, Wataru; Takai, Yoshiaki; Mori, Masahiko; Tsukitani, Kouji; Yang, Lizhen; Speight, Paul M.

doi:10.1267/ahc.32.305

Cited by 6 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is highly suggested that the functions of β-catenin depend on its subcellular localization since it is synthesized in the cytoplasm and transported to the nucleus to perform its transcriptional function; thus, membranous β-catenin mediates cell-cell adhesion, whereas the accumulation of cytoplasmic and nuclear pool of this protein is associated with oncogenic functions (24) . The exact role of β-catenin in the pathophysiology of salivary gland neoplasms is still not understood (25) , even its expression in normal salivary gland had some variation, as Yamada et al found negative expression of β-catenin in ductal and acinar compartments except for the striated duct of major salivary gland (26) . While others demonstrated positive membranous expression in the acinar and ductal compartments (27,28) .…”

Section: Discussionmentioning

confidence: 99%

Expression of β-catenin in Minor Salivary Glands Adjacent to Oral Squamous Cell Carcinoma

Ibraheem¹,

Mohammad²,

Hamied³

2020

SDJ

View full text Add to dashboard Cite

Objective: This study aims to evaluate the expression pattern, localization, and stain intensity of β-catenin in minor salivary glands adjacent to surgically excised oral squamous cell carcinoma (OSCC). Methods: A retrospective study was held with 16 samples of formalin-fixed paraffin-embedded blocks with minor salivary glands adjacent to OSCC. Sections were stained and evaluated immunohistochemically with β-catenin. The staining expression was assessed according to cellular localization, stain intensity, and, lastly, the pattern of stain distribution throughout acini. Statistical analysis was performed using SPSS version 24.0 software for Windows, and data analyzed by Fisher's exact test. P-value <0.05 was considered as statistically significant. Results: All minor salivary glands in the studied sample showed β-catenin staining with different expression in their functional units, as all had ductal and myoepithelial cells staining with a predominant cytoplasmic localization. While the mucous acini showed β- catenin expression in 10 cases (62.5%), this marker was significantly less frequently detected in serous acini of two cases of poorly differentiated OSCC (p= .008). A highly significant relation was found between the β-catenin cellular localization and stain distribution pattern in mucous and serous acini. Conclusions: β-catenin had altered cytoplasmic expression in all of the minor salivary glands adjacent to OSCC. Furthermore, the diffuse pattern of distribution throughout the acini could identify the multi-patches pathological alteration of this area. The current study clarifies that the adjacent clinically normal-appearing salivary glands could harbor genetic aberrations of their subsequent malignant transformation.

show abstract

Section: Discussionmentioning

confidence: 99%

Expression of β-catenin in Minor Salivary Glands Adjacent to Oral Squamous Cell Carcinoma

Ibraheem¹,

Mohammad²,

Hamied³

2020

SDJ

View full text Add to dashboard Cite

show abstract

Interlobular excretory ducts of mammalian salivary glands: Structural and histochemical review

2006

View full text Add to dashboard Cite

In the major salivary glands of mammals, excretory ducts (EDs) succeed striated ducts. They are for the most part interlobular in position, although their proximal portions sometimes are on the periphery of a lobule, where they occasionally retain some of the structural features of striated ducts. Based on a survey of a broad range of mammalian species and glands, the predominant tissue type that composes EDs is pseudostratified epithelium. In some species, there is a progression of epithelial types: the proximal EDs are composed of simple cuboidal or columnar epithelium that, in the excurrent direction, usually gives way to the pseudostratified variety. Secretory granules are visible in the apical cytoplasm of the principal cells of the EDs of only a few species, but histochemistry has shown the presence of a variety of glycoproteins in these cells in a spectrum of species. Moreover, the latter methodology has revealed the presence of a variety of oxidative, acid hydrolytic, and transport enzymes in the EDs, showing that, rather than simply acting as a conduit for saliva, these ducts play a metabolically active role in gland function. It is difficult to describe a "typical" mammalian ED because it can vary along its length and interspecific variation does not follow a phylogenetic pattern. Moreover, in contrast to intercalated and striated ducts, ED cellular features do not exhibit a relationship to diet. Anat Rec Part A 288A: 498 -526, 2006.

show abstract

Clinical implication of CD166 expression in salivary gland tumor

et al. 2014

View full text Add to dashboard Cite

CD166 is a glycoprotein of immunoglobulin superfamily of adhesion molecules which is overexpressed in many tumors. However, no published literature was found concerning CD166 expression in salivary gland tumor. The purpose of this study was to examine the CD166 expression in the salivary gland tumor by an immunohistochemical approach, to examine the clinical implication of this marker in the prognosis and diagnosis of the salivary gland tumor. In this study, 45 samples of salivary tumors from Khalili Hospital archive including 15 cases of pleomorphic adenoma, 16 cases of mucoepidermoid carcinoma, 14 cases of adenoid cystic carcinoma, and 15 normal salivary glands were selected for immunohistochemistry (IHC) method staining for CD166. CD166 immunoreactivity in malignant tumors (adenoid cystic carcinoma (ACC) and mucoepidermoid carcinoma (MEC)) (56.7 ± 14.05) was significantly higher than that of pleomorphic adenoma (PA) (34.3 ± 17.07) (P < 0.000) and higher in the PA than normal salivary gland (13.2 ± 12.1) (P = 0.001). CD166 expression was significantly higher in the high-grade tumors (90.3 ± 11.07) compared to low-grade (65.11 ± 27.08) malignant tumors (P = 0.002). CD166 expression showed a significant association with tumor size and the clinical stage (P < 0.001). In conclusion, an overexpression of CD166 was detected in the benign and malignant salivary gland tumors and its expression in the malignant tumor was associated with the aggressive behavior and tumor progression. For this reason, CD166 may be one of the potential biomarkers for predicting tumor behavior in the prognosis of this disease.

show abstract

Comparative Expression of E-cadherin, .ALPHA. and .BETA. Catenin in Salivary Gland Tumors.

Cited by 6 publications

References 13 publications

Expression of β-catenin in Minor Salivary Glands Adjacent to Oral Squamous Cell Carcinoma

Expression of β-catenin in Minor Salivary Glands Adjacent to Oral Squamous Cell Carcinoma

Interlobular excretory ducts of mammalian salivary glands: Structural and histochemical review

Clinical implication of CD166 expression in salivary gland tumor

Contact Info

Product

Resources

About