Comparative evaluation of wound healing potency of Vitex trifolia L. and Vitex altissima L.

Abstract

The wound healing potency of ethanol leaf extracts of V. trifolia L. and V. altissima L. was evaluated in excision, incision and dead space wound models. Both plants were found to possess significant wound healing activity which was evidenced by a decrease in the period of epithelialization, an increase in the rate of wound contraction, skin breaking strength, granulation tissue dry weight, hydroxyproline content and breaking strength of granulation tissue. Histopathological study of the granulation tissue also showed an increased collagenation when compared with the control group of animals. Of the two extracts, the ethanol leaf extract of V. trifolia showed maximum wound healing activity compared with the leaf extract of V. altissima. However, on comparison with the control group, both leaf extracts were found to possess significant wound healing potency.

Silibinin Regulates Matrix Metalloproteinase 3 (Stromelysine1) Gene Expression, Hexoseamines and Collagen Production During Rat Skin Wound Healing

“…A number of natural compounds isolated from plants and animals have been demonstrated as enhancers of wound healing in animal models (Manjunatha et al ., ; Nayak et al ., ; Oryan and Zaker, ). Data suggest that these compounds have antioxidant activity (Sen et al ., ).…”

“…In recent years, application of many medicinal plants has been increased in wound healing (Oryan et al ., ; Abenavoli et al ., ; Nayak et al ., ; Oryan et al ., ; Bodeker and Hughes, ; Ohshima et al ., ). Wound healing properties of these plant products are related to their components like tannins, saponins, flavonoids, napthaquinone, triterpenes and alkaloids (Hupkenes et al ., ; Martins et al ., ; Ohshima et al ., ; Abenavoli et al ., ; Manjunatha et al ., ).…”

Rapid in vitro propagation system through shoot tip cultures of Vitex trifolia L.–an important multipurpose plant of the Pacific traditional Medicine

“…The aerial parts of this plant are useful in the treatment of diabetes (Pullaiah and Naidu 2003). Besides, the plant also possesses larvicidal, wound healing, anti HIV, anticancer, trypanocidal, antibacterial and antipyretic activities (Li et al 2005;Woradulayapinij et al 2005;Kannathasan et al 2007;Manjunatha et al 2007).…”

Wound healing property review of siam weed, Chromolaena odorata

“…[7] Some examples of wound healing plants include korphad, Aloe vera ;[8] Madeira vines, Anredera diffusa ;[9] jungle geranium, Ixora coccinea ;[10] Indian mulberry, Morinda pubescens ;[11] simple-leaf chaste tree, Vitex trifolia ; and peacock chaste tree, Vitex altissima . [12] The present review provided an up-to-date information about the properties of Chromolaena odorata , one of the wound healing plants that is being investigated for its diverse health benefits.…”